The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Dermatomyositis associated with hepatitis B virus-related hepatocellular carcinoma

  • Yang, Suh Yoon (Department of Internal Medicine, Chung-Ang University College of Medicine) ;
  • Cha, Bong Ki (Department of Internal Medicine, Chung-Ang University College of Medicine) ;
  • Kim, Gihyeon (Department of Radiology, Chung-Ang University College of Medicine) ;
  • Lee, Hyun Woong (Department of Internal Medicine, Chung-Ang University College of Medicine) ;
  • Kim, Jae Gyu (Department of Internal Medicine, Chung-Ang University College of Medicine) ;
  • Chang, Sae Kyung (Department of Internal Medicine, Chung-Ang University College of Medicine) ;
  • Kim, Hyung Joon (Department of Internal Medicine, Chung-Ang University College of Medicine)
  • Received : 2012.09.26
  • Accepted : 2012.11.02
  • Published : 2014.03.01
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Abstract

Dermatomyositis is an idiopathic inflammatory myopathy with typical cutaneous manifestations. It has been proposed that dermatomyositis may be caused by autoimmune responses to viral infections. Previous studies have shown an association between dermatomyositis and malignant tumors such as ovarian cancer, lung cancer, and colorectal cancer. However, a chronic hepatitis B virus (HBV) infection associated with dermatomyositis and hepatocellular carcinoma (HCC) has been very rarely reported. Here, we report a rare case of dermatomyositis coinciding with HBV-associated HCC. A 55-year-old male was confirmed to have HCC and dermatomyositis based on proximal muscle weakness, typical skin manifestations, elevated muscle enzyme levels, and muscle biopsy findings. This case suggests that HCC and/or a chronic HBV infection may be factors in the pathogenesis of dermatomyositis through a paraneoplastic mechanism.

Keywords

References

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