The Korean journal of internal medicine

  • 제29권1호
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  • Pages.31-39
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  • 2014
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Measurement of antioxidant capacity using the biological antioxidant potential test and its role as a predictive marker of metabolic syndrome

  • Kim, Jung Hee (Department of Internal Medicine, Bundang Jesaeng Hospital) ;
  • Baik, Hyun Wook (Department of Internal Medicine, Bundang Jesaeng Hospital) ;
  • Yoon, Yeong Sook (Department of Family Medicine, Inje University Ilsan Paik Hospital) ;
  • Joung, Hyo Jee (Seoul National University Graduate School of Public Health) ;
  • Park, Ju Sang (Department of Internal Medicine, Bundang Jesaeng Hospital) ;
  • Park, Sang Jong (Department of Internal Medicine, Bundang Jesaeng Hospital) ;
  • Jang, Eun Jeong (Department of Internal Medicine, Bundang Jesaeng Hospital) ;
  • Park, Sang Woon (Department of Internal Medicine, Bundang Jesaeng Hospital) ;
  • Kim, Sang Jung (Department of Internal Medicine, Bundang Jesaeng Hospital) ;
  • Kim, Mi Jeoung (Department of Internal Medicine, Bundang Jesaeng Hospital) ;
  • Jeon, Dong Ok (Department of Internal Medicine, Bundang Jesaeng Hospital) ;
  • Cho, Hyo Jin (Department of Internal Medicine, Bundang Jesaeng Hospital) ;
  • Lee, Sang Jin (Department of Internal Medicine, Bundang Jesaeng Hospital) ;
  • Im, Sung Gyu (Department of Internal Medicine, Bundang Jesaeng Hospital) ;
  • Jang, Sun Kyung (Department of Internal Medicine, Bundang Jesaeng Hospital)
  • 투고 : 2012.08.10
  • 심사 : 2012.11.29
  • 발행 : 2014.01.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: Oxidative stress increases the risk of cardiovascular complications of metabolic syndrome (MetS). This study was conducted to examine the difference in antioxidant capacity according to the presence of MetS, and to characterize the association between antioxidant capacity and MetS-related factors. Methods: We used the biological antioxidant potential (BAP) test to estimate antioxidant capacity. The BAP test has recently been used as an indicator of antioxidant capacity. We measured BAP levels in 45 patients with MetS (mean age, $44.6{\pm}1.1$ years) and 47 age- and sex-matched controls (mean age, $42.7{\pm}1.1$ years). To evaluate the association between antioxidant capacity and MetS, adiponectin, high-sensitivity C-reactive protein (hs-CRP), interleukin-6, tumor necrosis factor-${\alpha}$, and homeostatic model assessment for insulin resistance (HOMA-IR), linear regression and logistic analyses were performed. Results: The mean BAP of the MetS group ($1,937.3{\pm}36.5{\mu}mol/L$) was significantly lower than that of the non-MetS group ($2,101.7{\pm}29.5{\mu}mol/L$). Also, the mean BAP was low in persons having low high density lipoprotein and high triglyceride. Reduced antioxidant capacity was significantly associated with adiponectin, HOMA-IR and hs-CRP after adjusting for age and sex. The odds ratios for MetS with BAP, log adiponectin, log HOMA-IR, and log hs-CRP were 0.63 (95% confidence interval [CI], 0.49 to 0.82), 0.22 (0.10 to 0.51), 14.24 (4.35 to 46.58), and 1.93 (1.36 to 2.75), respectively. Conclusions: Persons with MetS showed reduced antioxidant capacity. We identified relationships between antioxidant capacity measured by BAP test and MetS, as well as MetS-related factors, such as insulin resistance, hs-CRP, and adiponectin.

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