Korean Journal of Microbiology (미생물학회지)

The Microbiological Society of Korea (한국미생물학회)
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Antimicrobial Mechanisms of Nitric Oxide and Strategies for Developing Nitric Oxide-based Antimicrobial Agents

산화질소가 미생물에 미치는 영향 및 이를 이용한 항균전략

  • Received : 2014.05.07
  • Accepted : 2014.06.14
  • Published : 2014.06.30
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Abstract

Nitric oxide (NO), which has been recognized as an integral molecule in maintaining homeostasis, plays an important role in host defense against microbes. NO has diverse antimicrobial mechanisms by directly and/or indirectly interacting with microbes. Under the circumstance that there is an urgent need for a new class of antimicrobial agents due to antibiotic resistance, much effort has been made to develop a NO-based antimicrobial agent. In order to make it possible, strategies to store and release NO in a controlled manner are required because NO has a gaseous property and a very short half-life. In this review, we described NO biochemistry and its mechanisms of antimicrobial activity. In additions, we introduced various NO-releasing systems that improve NO's antimicrobial activity.

인체의 항상성 유지에 필수적인 물질로 알려진 산화질소는 인체를 침입한 미생물로부터 보호하는 면역반응에서 매우 중요한 역할을 담당하고 있다. 산화질소는 미생물에 직간접적으로 작용하여 다양한 기전으로 항균작용을 나타낸다. 항생제의 심각한 내성이 심각한 사회적 문제로 대두되면서 새로운 계열의 항생제 개발이 절실한 시점에서 항균물질로서의 산화질소에 대한 연구가 활발히 진행되고 있다. 하지만 매우 짧은 반감기와 기체분자인 산화질소를 항생제로 이용하기 위해서는 산화질소의 저장과 방출을 제어할 전략 필요하다. 본 총설에서는 산화질소의 체내에서의 생화학적 특성과 항균작용을 나타내는 다양한 기전에 대해 설명하였다. 또한 산화질소 방출을 조절하여 항균작용을 향상시키는 최근의 연구에 대해 알아보았다.

Keywords

References

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