DOI QR코드

DOI QR Code

Comparison of Psychotropic Prescriptions between Oncology and Cardiology Inpatients: Result from a Pharmacy Database in a Teaching Hospital in Malaysia

  • Ng, Chong Guan (Department of Psychological Medicine, University Malaya Medical Centre) ;
  • Mohamed, Salina (Department of Psychiatry, Faculty of Medicine, Universiti Teknologi MARA) ;
  • Wern, Tai Yi (Department of Pharmacy, University Malaya Medical Centre) ;
  • Haris, Azwa (Department of Pharmacy, University Malaya Medical Centre) ;
  • Zainal, Nor Zuraida (Department of Psychological Medicine, University Malaya Medical Centre) ;
  • Sulaim, Ahmad Hatim (Department of Psychological Medicine, University Malaya Medical Centre)
  • 발행 : 2014.05.30

초록

Objective: To examine the prescription rates in cancer patients of three common psychotropic drugs: anxiolytic/hypnotic, antidepressant and antipsychotic. Materials and Methods: In this retrospective cohort study, data were extracted from the pharmacy database of University Malaya Medical Center (UMMC) responsible for dispensing records of patients stored in the pharmacy's Medication Management and Use System (Ascribe). We analyzed the use of psychotropics in patients from the oncology ward and cardiology from 2008 to 2012. Odds ratios (ORs) were adjusted for age, gender and ethnicity. Results: A total of 3,345 oncology patients and 8,980 cardiology patients were included. Oncology patients were significantly more often prescribed psychotropic drugs (adjusted OR: anxiolytic/hypnotic=5.55 (CI: 4.64-6.63); antidepressants=6.08 (CI: 4.83-7.64) and antipsychotics=5.41 (CI: 4.17-7.02). Non-Malay female cancer patients were at significantly higher risk of anxiolytic/hypnotic use. Conclusions: Psychotropic drugs prescription is common in cancer patients. Anxiolytic/hypnotic prescription rates are significantly higher in non-Malay female patients in Malaysia.

키워드

참고문헌

  1. Adler NE, Page AEK, eds. (2007). Cancer Care for the Whole Patient: Meeting Psychosocial Health Needs. Washington, DC: National Academies Press.
  2. Butler LD, Koop C, Classen C, Spiegel D (1999). Traumatic stress, life events, and emotional support in women with metastatic breast cancer: cancer-related traumatic stress symptoms associated with past and current stressors. Health Psychol, 18, 555-60. https://doi.org/10.1037/0278-6133.18.6.555
  3. Caruso R, Grassi L, Nanni MG, Riba M (2013). Psychopharmacology in psycho-oncology. Curr Psychiatry Rep, 15, 393. https://doi.org/10.1007/s11920-013-0393-0
  4. Cullivan, Crown, Walsh (1998). The use of psychotropic medication in patients referred to a psycho-oncology service. Psychooncology, 7, 301-6. https://doi.org/10.1002/(SICI)1099-1611(199807/08)7:4<301::AID-PON367>3.0.CO;2-I
  5. Dastan NB, Buzlu S (2011). Depression and anxiety levels in early stage Turkish breast cancer patients and related factors. Asian Pac J Cancer Prev, 12, 137-41.
  6. Derogatis LR, Feldstein M, Morrow G, et al (1979). A survey of psychotropic drug prescriptions in an oncology population. Cancer, 44, 1919-29. https://doi.org/10.1002/1097-0142(197911)44:5<1919::AID-CNCR2820440555>3.0.CO;2-T
  7. Goldberg RJ, Mor V (1985). A survey of psychotropic use in terminal cancer patients. Psychosomatics, 26, 745-51. https://doi.org/10.1016/S0033-3182(85)72803-4
  8. Grabsch B, Clarke DM, Love A, et al (2006). Psychological morbidity and quality of life in women with advanced breast cancer: a cross-sectional survey. Palliat Support Care, 4, 47-56.
  9. Grassi L, Caruso R, Hammelef K, Nanni MG, Riba M (2014). Efficacy and safety of pharmacotherapy in cancer-related psychiatric disorders across the trajectory of cancer care: a review. Int Rev Psychiatry, 26, 44-62. https://doi.org/10.3109/09540261.2013.842542
  10. Hopwood P, Howell A, Maguire P (1991). Psychiatric morbidity in patients with advanced cancer of the breast: prevalence measured by two self-rating questionnaires. Br J Cancer, 64, 349-52. https://doi.org/10.1038/bjc.1991.304
  11. Khan NF, Ward AM, Watson E, et al (2010). Consulting and prescribing behaviour for anxiety and depression in longterm survivors of cancer in the UK. Eur J Cancer, 46, 3339-44. https://doi.org/10.1016/j.ejca.2010.07.035
  12. King M, Llewellyn H, Leurent B, et al (2013). Spiritual beliefs near the end of life: a prospective cohort study of people with cancer receiving palliative care. Psychooncology, 22, 2505-12. https://doi.org/10.1002/pon.3313
  13. Liu DG, Wang SS, Peng RJ, et al (2011). Interaction of social support and psychological stress on anxiety and depressive symptoms in breast cancer Patients. Asian Pac J Cancer Prev, 12, 2523-9.
  14. Maneeton B, Maneeton N, Mahathep P (2012). Prevalence of depression and its correlations: a cross-sectional study in Thai cancer patients. Asian Pac J Cancer Prev, 13, 2039-43. https://doi.org/10.7314/APJCP.2012.13.5.2039
  15. Merriam S, Muhamad M (2013). Roles traditional healers play in cancer treatment in Malaysia: implications for health promotion and education. Asian Pac J Cancer Prev, 14, 3593-601. https://doi.org/10.7314/APJCP.2013.14.6.3593
  16. Miovic M, Block S (2007). Psychiatric disorders in advanced cancer. Cancer, 110, 1665-76. https://doi.org/10.1002/cncr.22980
  17. Muriel AC, Hwang VS, Kornblith A, et al (2009). Management of psychosocial distress by oncologists. Psychiatric Services, 60, 1132-4. https://doi.org/10.1176/ps.2009.60.8.1132
  18. Muzzin LJ, Anderson NJ, Figueredo AT, Gudelis SO (1994). The experience of cancer. Soc Sci Med, 38, 1201-8. https://doi.org/10.1016/0277-9536(94)90185-6
  19. Ng CG, Boks MP, Smeets HM, Zainal NZ, de Wit NJ (2013a). Prescription patterns for psychotropic drugs in cancer patients: a large population study in the Netherlands. Psychooncology, 22, 762-7. https://doi.org/10.1002/pon.3056
  20. Ng CG, Dijkstra E, Smeets H, Boks MP, de Wit NJ (2013). Psychiatric comorbidity among terminally ill patients in general practice in the Netherlands: a comparison between patients with cancer and heart failure. Br J Gen Pract, 63, 63-8. https://doi.org/10.3399/bjgp13X660797
  21. Peterson LG, Leipman M, Bongar B (1987). Psychotropic medications in patients with cancer. Gen Hosp Psychiat, 9, 313-23. https://doi.org/10.1016/0163-8343(87)90062-4
  22. Ross DD, Alexender CS (2001). Management of common symptoms in terminally ill patients. I. Fatigue, anorexia, cachexia, nausea and vomitting. Am Fam Physician, 64, 807-14.
  23. Sahin ZA, Tan M, Polat H (2013). Hopelessness, depression and social support with end of life Turkish Cancer Patients. Asian Pac J Cancer Prev, 14, 2823-8. https://doi.org/10.7314/APJCP.2013.14.5.2823
  24. Shaharudin SH, Sulaiman S, Emran NA, Shahril MR, Syed Hussain SNA (2011). The use of complementary and alternative medicine among Malay breast cancer survivors. Altern Ther Health Med, 17, 50-6.
  25. Stromgren AS, Goldschmidht D, Groenvold M, et al (2002). Self-assessment in cancer patients referred to palliative care: a study of feasibility and symptom epidemiology. Cancer, 94, 512-20. https://doi.org/10.1002/cncr.10222
  26. Wilson KG, Chochinov HM, Skirko MG, et al (2007). Depression and anxiety disorders in palliative cancer care. J Pain Symptom Manage, 33, 118-29. https://doi.org/10.1016/j.jpainsymman.2006.07.016
  27. Yong CK, Young HY, Ki HL, et al (2006). Symptoms in the lives of terminal cancer patients: which is the most important? Oncology, 71, 69-76. https://doi.org/10.1159/000100450
  28. Zainal NZ, Nik-Jaafar NR, Baharudin A, Ahmad Sabki Z, Ng CG (2013). Prevalence of depression in breast cancer survivors: a systematic review of observational studies. Asian Pac J Cancer Prev, 14, 2649-56. https://doi.org/10.7314/APJCP.2013.14.4.2649

피인용 문헌

  1. Psychotropic drug initiation during the first diagnosis and the active treatment phase of B cell non-Hodgkin’s lymphoma: a cohort study of the French national health insurance database vol.24, pp.11, 2016, https://doi.org/10.1007/s00520-016-3331-y
  2. A systematic review and meta-analysis of prescribing practices of antidepressants in cancer patients vol.25, pp.9, 2016, https://doi.org/10.1002/pon.4048
  3. Anxiety and Depression in Cancer Patients: The Association with Religiosity and Religious Coping vol.56, pp.2, 2017, https://doi.org/10.1007/s10943-016-0267-y
  4. What type and dose of antidepressants are cancer and non-cancer inpatients being prescribed: a retrospective case-control study at an Australian tertiary hospital pp.1433-7339, 2017, https://doi.org/10.1007/s00520-017-3876-4
  5. Does Jacobson’s relaxation technique reduce consumption of psychotropic and analgesic drugs in cancer patients? A multicenter pre–post intervention study vol.18, pp.1, 2018, https://doi.org/10.1186/s12906-018-2200-2