Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Clinical and Prognostic Significance of SOX11 in Breast Cancer

  • Liu, Dao-Tong (Department of General Surgery, The First People's Hospital of Jining City Affiliated to Jining Medical University) ;
  • Peng-Zhao, Peng-Zhao (Department of Cardiothoracic Surgery, Jinxiang Hospital Affiliated to Jining Medical University) ;
  • Han, Jing-Yan (Department of Cardiothoracic Surgery, People's Hospital of Rizhao City) ;
  • Lin, Fan-Zhong (Department of Pathology, The First People's Hospital of Jining City Affiliated to Jining Medical University) ;
  • Bu, Xian-Min (Department of Pathology, The First People's Hospital of Jining City Affiliated to Jining Medical University) ;
  • Xu, Qing-Xia (Department of Pathology, The First People's Hospital of Jining City Affiliated to Jining Medical University)
  • Published : 2014.07.15
Download PDF
⟨ Previous Next ⟩

Abstract

Recently, the transcription factor SOX11 has gained extensive attention as a diagnostic marker in a series of cancers. However, to date, the possible roles of SOX11 in breast cancer has not been investigated. In this study, immunohistochemical staining for SOX11 was performed for 116 cases of breast cancer. Nuclear SOX11 was observed in 42 (36.2%) and cytoplasmic SOX11 in 52 (44.8%) of breast cancer samples. Moreover, high expression of cytoplasmic and nuclear SOX11 was associated with clinicopathological factors, including earlier tumor grade, absence of lymph node metastasis and smaller tumor size. Kaplan-Meier survival curves demonstrated high nuclear SOX11 expression to be associated with more prolonged overall survival than those with low expression and it could be an independent predictor of survival for breast cancer patients. It is worthwhile to note that cytoplasmic SOX11 was not correlated with prognosis of breast cancer patients. These data suggest the possibility that nuclear SOX11 could be as a potential target for breast cancer therapy.

Keywords

References

  1. Azuma T, Ao S, Saito Y, et al (1999). Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region. DNA Res, 6, 357-60. https://doi.org/10.1093/dnares/6.5.357
  2. Bergsland M, Werme M, Malewicz M, et al (2006). The establishment of neuronal properties is controlled by Sox4 and SOX11. Genes Dev, 20, 3475-86. https://doi.org/10.1101/gad.403406
  3. Brennan DJ, Ek S, Doyle E, et al (2009). The transcription factor SOX11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer. Eur J Cancer, 45, 1510-7. https://doi.org/10.1016/j.ejca.2009.01.028
  4. Chen YH, Gao J, Fan G, Peterson LC (2010). Nuclear expression of SOX11 is highly associated with mantle cell lymphoma but is independent of t (11;14)(q13; q32) in non-mantle cell B-cell neoplasms. Mod Pathol, 23, 105-12. https://doi.org/10.1038/modpathol.2009.140
  5. Conrotto P, Andreasson U, Kuci V, Borrebaeck CA, Ek S (2011). Knock- down of SOX11 induces autotaxin-dependent increase in proliferation in vitro and more aggressive tumors in vivo. Mol Oncol, 5, 527-37. https://doi.org/10.1016/j.molonc.2011.08.001
  6. Ek S, Dictor M, Jerkeman M, Jirstrom K, Borrebaeck CA (2008). Nuclear expression of the non B-cell lineage SOX11 transcription factor identifies mantle cell lymphoma. Blood, 111, 800-5. https://doi.org/10.1182/blood-2007-06-093401
  7. Fernandez V, Salamero O, Espinet B, et al (2010). Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma. Cancer research, 70, 1408-18. https://doi.org/10.1158/0008-5472.CAN-09-3419
  8. Hargrave M, Wright E, Kun J, et al (1997). Expression of the SOX11 gene in mouse embryos suggests roles in neuronal maturation and epithelio-mesenchymal induction. Dev Dyn, 210, 79-86. https://doi.org/10.1002/(SICI)1097-0177(199710)210:2<79::AID-AJA1>3.0.CO;2-6
  9. Khan HM, Saxena A, Gabbidon K, Rana S, Ahmed NU (2014). Model-based survival estimates of female breast cancer data. Asian Pac J Cancer Prev, 15, 2893-900. https://doi.org/10.7314/APJCP.2014.15.6.2893
  10. Kiefer JC (2007). Back to basics: SOX genes. Dev Dyn, 236, 2356-66. https://doi.org/10.1002/dvdy.21218
  11. Lee CJ, Appleby VJ, Orme AT, et al (2002). Differential expression of Sox4 and SOX11 in medulloblastoma. J. NeuroOncol, 57, 201-14. https://doi.org/10.1023/A:1015773818302
  12. Lefebvre V, Dumitriu B, Penzo-Mendez A, Han Y, Pallavi B (2007). Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors. Int J Biochem Cell Biol, 39, 2195-214. https://doi.org/10.1016/j.biocel.2007.05.019
  13. Madjd Z, Akbari ME, Zarnani AH, et al (2014). Expression of EMSY, a novel BRCA2-link protein, is associated with lymph node metastasis and increased tumor size in breast carcinomas. Asian Pac J Cancer Prev, 15: 1783-9. https://doi.org/10.7314/APJCP.2014.15.4.1783
  14. Mozos A, Royo C, Hartmann E, et al (2009). SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. Haematologica, 94, 1555-62. https://doi.org/10.3324/haematol.2009.010264
  15. Mutlu H, Akca Z, Cihan YB, et al (2013). Is season a prognostic factor in breast cancer? Asian Pac J Cancer Prev, 14, 743-6. https://doi.org/10.7314/APJCP.2013.14.2.743
  16. Pardali K, Moustakas A (2007). Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer. Biochim Biophys Acta, 1775, 21-62.
  17. Press MF, Pike MC, Chazin VR, et al (1993). Her-2/neu expression in node-negative breast cancer: direct tissue quantitation by computerized image analysis and association of overexpression within creased risk of recurrent disease. Cancer Res, 53, 4960-70.
  18. Siegel PM, Massague J (2003). Cytostatic and apoptotic actions of TGF- beta in homeostasis and cancer. Nat Rev Cancer, 3, 807-21. https://doi.org/10.1038/nrc1208
  19. Wang X, Asplund AC, Porwit A, et al (2008). The subcellular SOX11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival. Br J Haematol, 143, 248-52. https://doi.org/10.1111/j.1365-2141.2008.07329.x
  20. Wegner M (1999). From head to toes: the multiple facets of Sox proteins. Nucleic Acids Res, 27, 1409-20. https://doi.org/10.1093/nar/27.6.1409
  21. Weigle B, Ebner R, Temme A, et al (2005). Highly specific overexpression of the transcription factor SOX11 in human malignant gliomas. Oncol Rep, 13, 139-44.
  22. Zhang S, Li S, Gao JL (2013). Promoter methylation status of the tumor suppressor gene SOX11 is associated with cell growth and invasion in nasopharyngeal carcinoma. Cancer Cell Int, 13, 109. https://doi.org/10.1186/1475-2867-13-109

Cited by

  1. Apoptotic Effects of psiRNA-STAT3 on 4T1 Breast Cancer Cells in Vitro vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6977
  2. Gene expression profiling of breast cancer in Lebanese women vol.6, pp.1, 2016, https://doi.org/10.1038/srep36639
  3. Frequency and clinical implications of SOX11 expression in Burkitt lymphoma vol.58, pp.7, 2017, https://doi.org/10.1080/10428194.2016.1258701