Asian Pacific Journal of Cancer Prevention

  • 제15권13호
  • /
  • Pages.5317-5324
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Association Between Three eNOS Polymorphisms and Cancer Risk: a Meta-analysis

  • Wu, Xun (Department of Anatomy, School of Basic Medicine Science, Southern Medical University) ;
  • Wang, Zhi-Feng (Department of Anatomy, School of Basic Medicine Science, Southern Medical University) ;
  • Xu, Yin (Department of Urology, The First Affiliated Hospital of JINAN University) ;
  • Ren, Rui (Department of Andrology, Zhongshan City People's Hospital) ;
  • Heng, Bao-Li (Department of Urology, The First Affiliated Hospital of JINAN University) ;
  • Su, Ze-Xuan (Department of Anatomy, School of Basic Medicine Science, Southern Medical University)
  • 발행 : 2014.07.15
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초록

Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of cancer, but the results are still debatable. Therefore, we performed a systematic review to provide a more complete picture and conducted a meta-analysis to derive a precise estimation. We searched PubMed, EMBASE, EBSCO, Google Scholar and China National Knowledge Infrastructure (CNKI) databases until April 2014 to identify eligible studies. Thirty-one studies with cancer patients and controls were included in the meta-analysis. Overall, the polled analysis revealed that the T-786C polymorphism was significantly associated with increased cancer risk under multiple genetic models (C vs T: OR=1.135, 95%CI=1.048-1.228; CC vs TT: OR=1.278, 95%CI=1.045-1.562; TC vsTT: OR=1.136, 95%CI=1.023-1.261; CC+TC vs TT: OR=1.159, 95%CI=1.047-1.281; CC vs TC+TT: OR=1.204, 95%CI= 1.003-1.447). G894T was associated with significant risk for females (TT vs GG: OR=1.414, 95%CI=1.056-1.892; TT vs GT+GG: OR=1.356, 95%CI=1.108-1.661) and for breast cancer (T vs G: OR=1.097, 95%CI=1.001-1.203; TT vs GG: OR=1.346, 95%CI=1.012-1.789; TT vs GT+GG: OR=1.269, 95%CI=1.028-1.566). Increased susceptibility was revealed for prostate cancer with 4a/b (ba vs bb: OR=1.338, 95%CI=1.013-1.768; aa+ba vs bb: OR=1.474, 95%CI=1.002-2.170). This meta-analysis indicated that the eNOS T-786C polymorphism is associated with elevated cancer risk; the G894T polymorphism contributes to susceptibility to breast cancer and cancer generally in females; and the 4a/b polymorphism may be associated with prostate cancer risk.

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참고문헌

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피인용 문헌

  1. T-786C, G894T, and Intron 4 VNTR (4a/b) Polymorphisms of the Endothelial Nitric Oxide Synthase Gene in Bladder Cancer Cases vol.16, pp.6, 2015, https://doi.org/10.7314/APJCP.2015.16.6.2199
  2. The T-786C, G894T, and intron 4 VNTR (4a/b) polymorphisms of the endothelial nitric oxide synthase gene in prostate cancer cases vol.52, pp.2, 2016, https://doi.org/10.1134/S1022795416020022