Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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Role of Shinorine derived from Microalgae in skin protection

미세조류 유래 Shinorine의 피부세포에서의 효능

  • 정해수 ((주)바이오에프디엔씨 안티에이징연구소) ;
  • 조문진 ((주)바이오에프디엔씨 안티에이징연구소) ;
  • 서효현 ((주)바이오에프디엔씨 안티에이징연구소) ;
  • 아툴 쿨카르니 ((주)바이오에프디엔씨 안티에이징연구소) ;
  • 서승석 (한국해양과학기술원) ;
  • 이택견 (한국해양과학기술원) ;
  • 모상현 ((주)바이오에프디엔씨 안티에이징연구소)
  • Received : 2014.04.28
  • Accepted : 2014.07.10
  • Published : 2014.07.31
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Abstract

In the present study, mycosporine-like amino acids (MAAs)were extracted from in Chlamydomonas hedleyi, and their function was investigated regarding to protective capacity against UV radiation and a possibility to be developed into functional suncream including MAAs by using natural compounds. In particulr, we assessed UV protective ability and anti-inflammation of shinorine in human skin cells. As a result, shinorine can protect the skin against damage by the absorption of energy from UV radiation and functions as an anti-wrinkling substrate through a increase of collagen synthesis. These data suggest that shinorine can be utilized not only as a substrate to protect UV radiation, but anti-aging material in cosmetic products.

오존층의 파괴와 증가하는 야외활동으로 인한 자외선의 노출을 최소화 하기위해 자외선 차단제는 필수적인 것이 되고 있다. 기존에 사용되는 자외선 차단제의 기능을 향상시키며 부작용을 줄이기 위해 천연식물과 같은 친환경적인 소재의 개발이 필요한 실정이다. 본 연구는 천연물을 활용한 자외선차단제 및 기능성 화장품 소재 개발을 위해 미세조류(Chlamydomonas hedleyi.)로부터 Mycosporine-like amino acid (MAA)를 분리 정제하고 그 효능을 평가하고자 하였다. 미세조류에서 분리 정제한 MAAs 중 shinorine을 분리하여 UV에 의한 피부세포의 손상을 막고, 염증과 관련 있는 단백질의 발현을 저해하는지를 평가하였다. 그 결과 shinorine이 피부세포가 UV에 의해 손상되는 것을 보호하여 cell viability가 10% 증가하였고, 염증관련 단백질인 COX2이 발현이 41%정도 감소하는 것을 확인하였다. 또한 콜라겐의 합성을 증가시켜 주름개선 효능을 확인하였다. 이에 shinorine은 자외선 차단용 소재뿐 아니라 항노화 관련 제품의 소재로 가능성을 확인하였다.

Keywords

References

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