한국산업보건학회지 (Journal of Korean Society of Occupational and Environmental Hygiene)

  • 제24권2호
  • /
  • Pages.130-136
  • /
  • 2014
  • /
  • 2384-132X(pISSN)
  • /
  • 2289-0564(eISSN)
한국산업보건학회 (Korean Industrial Hygiene Association)
권호 표지
DOI QR코드

DOI QR Code

한국산 백석면이 랫드의 폐 기능에 미치는 영향 평가 연구

Effect of Korean Chrysotile on the Lung Function of Rats

  • 정용현 (산업안전보건연구원 독성연구팀) ;
  • 강민구 (산업안전보건연구원 독성연구팀) ;
  • 한정희 (산업안전보건연구원 독성연구팀)
  • Chung, Yong Hyun (Toxicity Research Team, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Kang, Min Gu (Toxicity Research Team, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Han, Jeong Hee (Toxicity Research Team, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
  • 투고 : 2014.04.04
  • 심사 : 2014.05.22
  • 발행 : 2014.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: To evaluate the pulmonary toxicity of Korean Chrysotile(KC), the lung function and the number of fibers in the bronchoalveolar lavage fluid of Sprague-Dawley rats instilled with KC were estimated. Materials: Rats were administered 1 mg KC by a single intratracheal instillation. At each time point(5 days, 5 weeks, 10 weeks), the lung function of the rats was analyzed by pressure transducer and the amount of asbestos in the bronchoalveolar lavage fluid of the rats was calculated by transmission electron microscope equipped with energy dispersive X-ray spectrometer. Results: The lung function of the rats at 5 days after instillation of KC was confirmed to be degraded. However, after 5 weeks the test groups showed a tendency to recover lung function. Still, after 10 weeks the lung function of the test groups had not recovered completely. The number of fibers in the bronchoalveolar lavage fluid of the rats instilled with KC rapidly decreased. At 5 weeks the number of fibers had reduced to approximately 1/2 of that found at 5 days. Over time, at 10 weeks it had rapidly decreased to 1/100 that found at 5 days. Conclusions: Korean chrysotile fibers rapidly decreased in the lungs of rats, but the lung function of rats instilled KC does had not completely recovered by 10 weeks.

키워드

참고문헌

  1. Bellmann B, Muhle H, Kamstrup O, Graeger UF. Investigation of the biodurability of man made vitreous fibers ion rat lungs. Environ Health perspect. 1997;102(suppl 5): 185-189
  2. Bernstein DM, Dunnigan J, Hesterberg T, Brown R, Velasco JA et al. Health risk of chrysotile revisited Crit Rev Toxicol 2013 Feb;43(2):154-83 https://doi.org/10.3109/10408444.2012.756454
  3. Bernstein DM, Chevalier J, Smith P. Comparison of Calidria chrysotile asbestos to pure tremolite: final results of the inhalation biopersistence and histopathology following short term exposure. Inhal Toxicol 2005;17:427-49 https://doi.org/10.1080/08958370591002012
  4. Bernstein DM, Rogers RA, Smith P, Chevalier J. The toxicological response of Brazilian chrysotile asbestos: a multidose sub-chronic 90 d inhalation toxicology study with 92 day recovery to assess cellular and pathological response. Inhal Toxicol 2006;18:313-32 https://doi.org/10.1080/08958370500515871
  5. Bernstein DM, Rogers RA, Sepulveda R, Donaldson K, Schuler D et al. The pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short term inhalation exposure-interim results. Inhal Toxicol 2010;22:937-62 https://doi.org/10.3109/08958378.2010.497818
  6. Bernstein DM, Rogers RA, Sepulveda R, Donaldson K, Schuler D et al. Quantification of the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite-asbestos following short-term inhalation exposure. Inhal Toxicol 2011;23:372-91 https://doi.org/10.3109/08958378.2011.575413
  7. Chung YH, Han JH, Kang MK. Dose-response assessment and physicochemical characteristics on Korean chrysotile. Occupational Safety & Health Research Institute; 2013. p. 3
  8. De Vuyst P, Gevenois PA. Asbestosis. In: Hendrick DJ, Burge PS, Beckett WS, Churg A, eds. Occupational Disorders of the Lung: Recognition, Management, and Prevention. London, England: Saunders; 2002:143-162
  9. Green FH, Harley R, Vallyathan V, Althouse R, Fick G et al. Exposure and mineralogical correlates of pulmonary fibrosis in chrysotile asbestos workers. Occup Environ Med 1997;54(8):549-559 https://doi.org/10.1136/oem.54.8.549
  10. Hume LA, Rimstidt JD. The biodurability of chrysotile. Am Mineral 1992; 77(9-0):1125-1128
  11. Korea environment corporation, asbestos damage relief center. 2014; https://www.env-relief.or.kr:444/arms/main/main.jsp
  12. Ministry of Employment and Labor. 2014; http://www.moel.go.kr/
  13. Roggli VL, Gibbs AR, Attanoos R, Churg A, Popper H et al. Pathology of asbestosis- An update of the diagnostic criteria: Report of the asbestosis committee of the college of american pathologists and pulmonary pathology society. Arch Pathol Lab Med 2010 Mar;134(3):462-80