Pediatric Gastroenterology, Hepatology & Nutrition

The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition (대한소아소화기영양학회)
권호 표지
DOI QR코드

DOI QR Code

Two Cases of Infantile Intra-abdominal Inflammatory Myofibroblastic Tumor

  • Kim, Soo-Hong (Division of Pediatric Surgery, Department of Surgery, Pusan National University Children’s Hospital, Pusan National University School of Medicine) ;
  • Cho, Yong Hoon (Division of Pediatric Surgery, Department of Surgery, Pusan National University Children’s Hospital, Pusan National University School of Medicine) ;
  • Kim, Hae Young (Division of Pediatric Surgery, Department of Surgery, Pusan National University Children’s Hospital, Pusan National University School of Medicine)
  • Received : 2014.03.25
  • Accepted : 2014.04.14
  • Published : 2014.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Inflammatory myofibroblastic tumor (IMT) is rare mesenchymal solid tumor that consists of proliferating myofibroblasts with an inflammatory infiltrate background. It has a very low prevalence in infants and occurs mainly in children and young adults. IMT are mainly located in the thoracic cavity, but intra-abdominal lesions are rare. IMT can exhibit locally aggressive neoplastic processes and metastases similar to malignancies, so, have clinical importance. Herein, we describe two infantile intra-abdominal IMT cases presenting with incidentally found palpable abdominal mass. A 4-month-old male infant had IMT at the ileal mesentery and a 5-month-old male infant had IMT at liver. Both cases were successfully treated by complete surgical resection without complication or recurrence. Considering the biological behavior of the intermediate type of neoplasm in IMT, we expect good survivals when achieving appropriate surgical resection without adjuvant therapy in infantile intra-abdominal IMT.

Keywords

References

  1. Kim EY, Lee IK, Lee YS, Yang N, Chung DJ, Yim KI, et al. Inflammatory myofibroblastic tumor in colon. J Korean Surg Soc 2012;82:45-9. https://doi.org/10.4174/jkss.2012.82.1.45
  2. Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R, et al. Inflammatory myofibroblastic tumors. J Surg Oncol 2006;94:385-91. https://doi.org/10.1002/jso.20516
  3. Kim HY, Moon SB, Jung SE, Lee SC, Park KW, Kim WK. Abdominal inflammatory myofibroblastic tumor in children. J Korean Assoc Pediatr Surg 2008;14:153-63.
  4. Kim SJ, Kim WS, Cheon JE, Shin SM, Youn BJ, Kim IO, et al. Inflammatory myofibroblastic tumors of the abdomen as mimickers of malignancy: imaging features in nine children. AJR Am J Roentgenol 2009;193:1419-24. https://doi.org/10.2214/AJR.09.2433
  5. Singhal M, Ramanathan S, Das A, Singh G, Bagga R, Khandelwal N. Omental inflammatory myofibroblastic tumour mimicking peritoneal carcinomatosis. Cancer Imaging 2011;11:19-22.
  6. Ong HS, Ji T, Zhang CP, Li J, Wang LZ, Li RR, et al. Head and neck inflammatory myofibroblastic tumor (IMT): evaluation of clinicopathologic and prognostic features. Oral Oncol 2012;48:141-8. https://doi.org/10.1016/j.oraloncology.2011.09.004
  7. Fragoso AC, Eloy C, Estevão-Costa J, Campos M, Farinha N, Lopes JM. Abdominal inflammatory myofibroblastic tumor a clinicopathologic study with reappraisal of biologic behavior. J Pediatr Surg 2011;46:2076-82. https://doi.org/10.1016/j.jpedsurg.2011.07.009
  8. Woo MJ, Yu HY, Kim BS, Won SC, Lyu CJ, Oh JT. Inflammatory myofibroblastic tumor in a 3 months old infant. Clin Pediatr Hematol Oncol 2011;18:62-5.
  9. Kye BH, Kim HJ, Kang SG, Yoo C, Cho HM. A case of inflammatory myofibroblastic tumor originated from the greater omentum in young adult. J Korean Surg Soc 2012;82:380-4. https://doi.org/10.4174/jkss.2012.82.6.380
  10. Bertocchini A, Lo Zupone C, Callea F, Gennari F, Serra A, Monti L, et al. Unresectable multifocal omental and peritoneal inflammatory myofibroblastic tumor in a child: revisiting the role of adjuvant therapy. J Pediatr Surg 2011;46:e17-21.
  11. Li J, Yin WH, Takeuchi K, Guan H, Huang YH, Chan JK. Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement: a report of two cases and literature review. Diagn Pathol 2013;8:147. https://doi.org/10.1186/1746-1596-8-147
  12. Chun YS, Wang L, Nascimento AG, Moir CR, Rodeberg DA. Pediatric inflammatory myofibroblastic tumor: anaplastic lymphoma kinase (ALK) expression and prognosis. Pediatr Blood Cancer 2005;45:796-801. https://doi.org/10.1002/pbc.20294

Cited by

  1. Hepatic inflammatory pseudotumor presenting in an 8-year-old boy: A case report and review of literature vol.21, pp.28, 2014, https://doi.org/10.3748/wjg.v21.i28.8730
  2. Incomplete Intestinal Obstruction Caused by a Rare Epithelioid Inflammatory Myofibroblastic Sarcoma of the Colon : A Case Report vol.94, pp.51, 2014, https://doi.org/10.1097/md.0000000000002342
  3. Inflammatory myofibroblastic duodenal tumor: A rare cause of massive intestinal bleeding vol.16, pp.4, 2014, https://doi.org/10.3233/cbm-160597
  4. Inflammatory myofibroblastic tumor of kidney together with ipsilateral perinephric and periureteric fibrosis : A case report and literature review vol.96, pp.49, 2017, https://doi.org/10.1097/md.0000000000008807