Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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The Effect of Meliae toosendan fructus Ethanol Extract on Blood Glucose, Lipid metabolism, Carbohydrate Methabolism Related Enzyme Activities and Antioxidative Effect in Streptozotocin-Induced Diabetic Rats

천련자 에탄올 추출물이 Streptozotocin으로 유발된 당뇨 흰쥐에 대한 혈당, 지질대사, 당대사 효소 활성과 항산화 작용에 미치는 영향

  • Kim, Ok-Kyung (Department of Food Science and Nutrition, Dae Jin University,) ;
  • Leem, Hee-Jin (Department of Food Science and Nutrition, Dae Jin University,) ;
  • Je, Jung-Min (Department of Food Science and Nutrition, Dae Jin University,) ;
  • Lee, Gyung-Mi (Department of Food Science and Nutrition, Dae Jin University,)
  • 김옥경 (대진대학교 자연과학대학 식품영양학과) ;
  • 임희진 (대진대학교 자연과학대학 식품영양학과) ;
  • 제정민 (대진대학교 자연과학대학 식품영양학과) ;
  • 이경미 (대진대학교 자연과학대학 식품영양학과)
  • Received : 2014.05.31
  • Accepted : 2014.06.24
  • Published : 2014.06.30
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Abstract

The ethanol extraction yield of Meliae toosendan fructus(MT) was about 24.5% by extract apparatus. This study was done to investigate the carbohydrate metabolism related enzyme activities and antioxidative effects of MT in streptozotocin (STZ)-induced diabetic rats. The contents of serum glucose, triglyceride (TG) were significantly decreaed in MT treated group compared to the those of STZ-control group, also content of Total cholesterol was decreased. High density lipoprotein (HDL)-cholesterol was increased in MT treated group. The activity of glucose-6-pase(G-6-Pase) was significantly decreased in MT treated group. Also the activities of glucose-6-phosphate dehydrogenase(G-6-PDH) and glucokinase(Gk) were increaed in MT treated group. The content of hepatic glycogen was significantly increaed in MT treated group, in addition, content of malondialdehyde(MDA) was significanly decreased in MT treated group. Also, content of glutathione(GSH)was dereased in MT treated froup. whereas, activity of catalase(CAT) was significantly increaed in MT treated group compared to the those of STZ-control group. activity of glutathione peroxidase(GSH-Px) was inecreaed. In conclusion, these results indicated that ethanol extract of MT would have carbohydrate metabolism antioxidative effects in STZ-induced diabetic rats.

Keywords

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