The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Inhibitory Effect of a decoction composed of Evodia rutaecarpa (Juss.) Benth. and Chaenomeles sinensis Koehne and its component herbal medicines on Collagen II-induced Arthritis Mice

Collagen II-induced Arthritis 생쥐에 대한 오수유(吳茱萸), 목과(木瓜) 및 배합약물의 관절염 억제 효과

  • Park, Dae-Jung (Department of Herbology, College of Korean Medicine, Sangji University) ;
  • Lee, Young-Cheol (Department of Herbology, College of Korean Medicine, Sangji University) ;
  • Lee, Jang-Cheon (Division of Pharmacology and Basic Korean Medicine, School of Korean Medicine, Pusan National University)
  • 박대중 (상지대학교 한의과대학 본초학교실) ;
  • 이영철 (상지대학교 한의과대학 본초학교실) ;
  • 이장천 (부산대학교 한의학전문대학원 약물의학부)
  • Received : 2014.06.10
  • Accepted : 2014.07.16
  • Published : 2014.07.30
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Abstract

Objectives : Evodia rutaecarpa (Juss.) Benth.(ER) and Chaenomeles sinensis Koehne (CS) have multiple applications and were known to have anti-inflammatory effects. In the current study, we investigated to clearly understand the mechanism of therapeutic role for CS, ER and their combination in CIA model mice. Methods : DBA/1OlaHsd mice were immunized with bovine type II collagen. After a second collagen immunization, mice were treated with CS, ER and their combination once a day for 7 weeks. Cytokine production and gene expression were assessed during CIA (collagen-induced arthritis) model mice in knee joint, lymph node (LN) using ELISA and FACS analysis. The severity of arthritis within the knee joints was evaluated by histological assessment of cartilage destruction and pannus formation. Result : Oral administration of CS, ER and their combination (150 mg/kg) significantly suppressed the progression of CIA, and significantly suppressed the progression of CIA and inhibited the production of TNF-${\alpha}$ and IL-6 in serum. The erosion of cartilage was dramatically reduced in mouse knees after treatment with CS plus ER. Conclusion : These result suggest that CS plus ER significantly suppressed the progression of CIA and that this action was characterized by the decreased production of TNF-${\alpha}$, IL-6 and collagen II specific antibody in serum.

Keywords

References

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