Prevalence of Ruminal Lactic Acidosis and Clinical Assessments of Four Therapeutics in Goats of Bangladesh

방글라데시 염소에서 유산증의 분포 및 4가지 치료법의 임상적 적용

  • Rahman, Md. Mahbubur (Additional Veterinary Surgeon, District Veterinary Hospital, Faridpur, Bangladesh and Department of Surgery and Obstetrics, Bangladesh Agricultural University) ;
  • Islam, Mohammad Saiful (College of Veterinary Medicine and Bio-safety Research Centre, Chonbuk National University) ;
  • Adam, G.O. (Department of Vet. Medicine, Pharmacolgy & Toxicology, Sudan University of Science and Technology) ;
  • Alam, Md. Rafiqul (Department of Surgery and Obstetrics, Bangladesh Agricultural University) ;
  • You, Myung-Jo (College of Veterinary Medicine and Bio-safety Research Centre, Chonbuk National University)
  • ;
  • ;
  • ;
  • ;
  • 유명조 (전북대학교 수의과대학)
  • Accepted : 2014.01.25
  • Published : 2014.06.30

Abstract

Acidosis conditions either acute or chronic following ingestion of excessive amounts of readily fermented carbohydrate are great production problems for goat in Bangladesh. This study designed to investigate the prevalence of lactic acidosis and then response to different therapeutic agents. For this purpose, 1,128 goat were examined at outdoor District Veterinary Hospital, Faridpur, Bangladseh for treatment of which 40 goats were found positive for lactic acidosis showing 3.55% prevalence of disease. The highest occurrence found in female (4.64%) of over 3 years age (4.64%) in indigenous goat (2.7%). For therapeutic assessment the forty affected goats were divided into four groups A, B, C and D comprising of 10 animals each. Group A were given magnesium hydroxide 8% w/v at 1 g/kg body weight orally. In group B magnesium hydroxide 8% w/v at a dose as group A combination with 7.5% sodium bicarbonate at the rate of 0.9 ml/Kg body weight intravenously administered. Goat in group D were treated with mixture of ginger, nuxvomica, sodium carbonate, cobalt sulphate, dried ferrous sulphate and thiamin mononitrate at the rate of 1 g/kg body weight orally. Goat of group C treated with combination drugs of group A, B and D. The rectal temperature, pulse rate, respiration rate, was performed before and after treatment. It was found that the highest recovery in group C with an average period of $21{\pm}1.8$ hours. It was concluded that lactic acidosis is a common disease of goats and its severity can be effectively reduced by using combination drugs.

쉽게 발효되는 탄수화물의 과도한 양의 섭취에 따른 급성 또는 만성의 산증은 방글라데시에서 염소의 생산성 문제로 나타나고 있다. 본 연구는 유산증의 분포와 다른 치료제간의 반응을 조사하였다. 본 연구를 위해, 야외 지역 동물 병원, Faridpur, Bangladseh에서 조사 한 1,128마리의 염소가 검사 되었으며, 그 중 40마리의 염소(3.55%의 분포율)가 유산증에 대해 양성으로 확인되었다. 토종 염소 (2.7%)에서는 3 년 이상된 연령(4.64%)의 암컷 (4.64%)에서 가장 높은 발병을 보였다. 40마리 염소의 치료 평가를 위해서 염소는 그룹당 10마리씩 4개의 그룹 A, B, C와 D로 분류 하였다. 그룹A는 경구, 8% 수산화 마그네슘(v/w)을 체중 1 g/kg으로 경구 투여 하였다. 그룹 B에서는 그룹 A와 같은 량의 8% 수산화 마그네슘에 더하여 체중 0.9 ml/kg 비율로 7.5%의 중탄산 나트륨을 정맥 내 투여 하였다. 그룹 D에서 염소는 생강, nuxvomica, 탄산나트륨, 황산 코발트, 분말 형태의 황산제1철 과 티아민 질산염의 혼합물을 1 g/kg 체중의 비율로 경구 투여하였다. 그룹 C의 염소는 그룹 A, B와 D의 조합 약물로 치료하였다. 각 그룹은 치료 전후에 직장 온도, 맥박수, 호흡 수를 검사하였다. 평균 $21{\pm}1.8$ 시간으로 그룹 C가 가장 높은 회복률을 보였다. 결론적으로 유산증은 염소에서 흔한 질병이며 치료효과는 약물의 조합을 통해서 효과적으로 증상을 감소 시킬 수 있었다.

Keywords

References

  1. Basak DN, Sarker S, Chakrabarti A. A note on gastroenterilogical changes in experimental acid indigestion in goats. Ind J Med 1993; 13: 32-33.
  2. Blood DC, Johnson G. Recording of O.M. In: Veterinary Medicine, 7th ed. London: Bailliere Tindall. 1989: 124-130.
  3. Borrelli F, Capasso R, Aviello G, Pittler MH, Izzo AA. Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Obstet Gynecol 2005; 105: 849-856. https://doi.org/10.1097/01.AOG.0000154890.47642.23
  4. Bowen R. Ruminal Tympany (Bloat, Hoven). In: Digestive physiology of Herbivores. Queensiand: DPI&F Publishers. 2006: 16-20Chaplin RK, Jones GA. Rumen microbial changes during experimental acidosis. J Dairy Sci 1973; 56: 671.
  5. Coa GR, English PB, Fillippich LJ, Inglish S. Experimentally induced lactic acidosis in the goats. Aus Vet J 1987; 64: 367-370. https://doi.org/10.1111/j.1751-0813.1987.tb09605.x
  6. De Brabander DL, De Boever JL, Vanacker JM, Geerts NE. Evaluation and effects of physical structure in dairy cattle nutrition. In: Recent Developments and Perspectives in Bovine Medicine. Hannover: Proc. 22nd World Buiatrics Congress. 2002: 182-197.
  7. Habremariam T, Adams EW. A system view. In: Veterinary Health Care Delivery. Tuskegee: Tuskagee Institute. 1981: 1-5.
  8. Hillman RS, Finch CA. Drugs effective in iron-deficiency and other hypochromic anemias. In: The Pharmacological Basis of Therapeutics, 7th ed. New York: Macmillan Publishing. 1985: 1308-1322.
  9. Jani RG, Jani BM, Patel PR. Clinico-pathological studies of ruminal acidosis. Ind J Vet Med 2001; 21: 105.
  10. Lal SB, Dwivedi SK, Sharma MC, Swarup D. Influence of acidosis on blood biochemical values in goats. Ind J Vet Med 1990; 10: 125-128.
  11. Mohamed Nour MS, Abusamra MT, Hago BED. Experimentally induced lactic acidosis in Nubian goats: Clinical, biochemical and pathological investigations. Small Rum Res 1998; 31: 7-17. https://doi.org/10.1016/S0921-4488(98)00116-3
  12. Radostits OM, Gay CC, Blood DC, Hinchcliff KW. In: Veterinary Medicine, 9th ed. Philadelphia: WB Saunders Company. 2000: 293-303.
  13. Samad MA. LEP Publication No. 07. In: Veterinary Practitioner's Guide. Mymensingh: LEP. 2000: 62-63.
  14. Smith GW, Correa MT. The effects of oral magnesium hydroxide administration on rumen fluid in cattle. J Vet Intern Med 2004; 18: 109-112. https://doi.org/10.1111/j.1939-1676.2004.tb00143.x
  15. Suzuki K, Ajito T, Okumura J, Iwabuchi S. Effect of rapid intravenous infusion of a 7.0% sodium bicarbonate solution on arteriel blood gases of heifers. The Tohoku J Vet Clin 1999; 22: 9-14. https://doi.org/10.4190/jjvc1990.22.9
  16. Williams RR, Cline JK. Synthesis of vitamin B. J Am Chem Soc 1936; 58: 1504-1505. https://doi.org/10.1021/ja01299a505
  17. Wilson JD, Braunwald E, Isselbacher KJ, Petersdorf RG, Martin JB, Fauci AS, Root RK. In: Harrison's principles of internal medicine, 12th ed. New York: McGraw-Hill. 1991; 1518-1523, 1833-1834.