Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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The relationship between eosinophilia and bronchopulmonary dysplasia in premature infants at less than 34 weeks' gestation

  • Yang, Joo Yun (Department of Pediatrics, Ewha Womans University School of Medicine) ;
  • Cha, Jihei (Department of Pediatrics, Ewha Womans University School of Medicine) ;
  • Shim, So-Yeon (Department of Pediatrics, Ewha Womans University School of Medicine) ;
  • Cho, Su Jin (Department of Pediatrics, Ewha Womans University School of Medicine) ;
  • Park, Eun Ae (Department of Pediatrics, Ewha Womans University School of Medicine)
  • 투고 : 2013.09.13
  • 심사 : 2013.11.21
  • 발행 : 2014.04.15
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초록

Purpose: Eosinophilia is common in premature infants, and its incidence increases with a shorter gestation period. We investigated the clinical significance of eosinophilia in premature infants born at <34 weeks gestation. Methods: We analyzed the medical records of premature infants born at <34 weeks gestation who were admitted to the neonatal intensive care unit at Ewha Womans University Mokdong Hospital between January 2003 and September 2010. Eosinophilia was defined as an eosinophil percentage of >3% of the total leukocytes. Perinatal parameters and clinical parameters were also analyzed. Results: Of the 261 infants born at <34 weeks gestation, 22.4% demonstrated eosinophilia at birth. The eosinophil percentage peaked in the fourth postnatal week at 7.5%. The incidence of severe eosinophilia increased after birth up to the fourth postnatal week when 8.8% of all patients had severe eosinophilia. Severity of eosinophilia was positively correlated with a lower gestational age, birth weight, and Apgar score. Respiratory distress syndrome, bronchopulmonary dysplasia, nephrocalcinosis, intraventricular hemorrhage, and sepsis were associated with a higher eosinophil percentage. The eosinophil percentage was significantly higher in infants with bronchopulmonary dysplasia from the first postnatal week and the percentage was the highest in the fourth postnatal week, with the maximal difference being 4.1% (P<0.001). Conclusion: Eosinophilia is common in premature infants and reaches peak incidence and severity in the fourth postnatal week. The eosinophil percentage was significantly higher in bronchopulmonary dysplasia patients from the first postnatal week. Severe eosinophilia was significantly associated with the incidence of bronchopulmonary dysplasia even after adjusting for other variables.

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참고문헌

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피인용 문헌

  1. Serum Eotaxin-1 is Increased in Extremely Low Birth Infants with Bronchopulmonary Dysplasia or Death vol.78, pp.5, 2014, https://doi.org/10.1038/pr.2015.152
  2. Increased serum Th2 chemokine levels are associated with bronchopulmonary dysplasia in premature infants vol.178, pp.1, 2014, https://doi.org/10.1007/s00431-018-3266-z
  3. Features of the course of bronchial asthma in children with a history of bronchopulmonary dysplasia vol.65, pp.4, 2020, https://doi.org/10.21508/1027-4065-2020-65-4-101-107
  4. Impact and Clinical Implications of Prematurity on Adaptive Immune Development vol.8, pp.4, 2014, https://doi.org/10.1007/s40124-020-00234-5
  5. Invasive mechanical ventilation and biomarkers as predictors of bronchopulmonary dysplasia in preterm infants vol.97, pp.3, 2014, https://doi.org/10.1016/j.jped.2020.03.006