Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
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Prognostic Significance of Claudin 4 in Completely Resected Adenocarcinoma of the Lung

  • Chae, Min Cheol (Department of Thoracic and Cardiovascular Surgery, Keimyung University Dongsan Medical Center) ;
  • Park, Chang Kwon (Department of Thoracic and Cardiovascular Surgery, Keimyung University Dongsan Medical Center) ;
  • Keum, Dong Yoon (Department of Thoracic and Cardiovascular Surgery, Keimyung University Dongsan Medical Center) ;
  • Hwang, Ilseon (Department of Pathology, Keimyung University Dongsan Medical Center) ;
  • Kwon, Kun Young (Department of Pathology, Keimyung University Dongsan Medical Center) ;
  • Jang, Byeong Churl (Department of Medical Genetic Engineering, Keimyung University School of Medicine)
  • Received : 2013.08.27
  • Accepted : 2013.10.25
  • Published : 2014.06.05
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Abstract

Background: The development of diagnostic techniques and an awareness of health examinations can bring about an early diagnosis of lung cancer. However, appropriate postoperative management and adjuvant chemotherapy remain under debate in postoperative therapeutic strategy. The present study was conducted to assess the clinicopathologic factors that influence recurrence and prognosis after complete resection of lung cancer. Methods: The present study analyzed 62 patients with lung cancer who underwent complete resection of diagnosed adenocarcinoma between 1994 and 2007. In addition to conventional factors, which include staging factor and histological evaluation, the present study also performed univariate and multivariate analyses to consider claudin, a cell adhesion molecule, as a prognostic factor by immunohistochemical staining. Results: There was no correlation between conventional factors, including lymphatic and vascular invasion, and recurrence. However, there was a significant correlation between high expression of claudin 4 and cancer recurrence. In particular, there was a correlation between high expressions of claudin 1, 4, and 5 and a reduction of disease-free survival. Conclusion: Increased expressions of claudin 4 were negative prognostic factors in adenocarcinoma of the lung and thus could be used to identify high-risk patients for adjuvant chemotherapy, even if they had early-stage lung cancer. The present findings collectively suggest that consideration of claudin as a prognostic factor in the active postoperative treatment in patients at high risk will lead to better therapeutic outcomes with fewer side effects.

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