한국동물위생학회지 (Korean Journal of Veterinary Service)

  • 제37권2호
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  • Pages.101-104
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  • 2014
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  • 3022-7372(pISSN)
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  • 2287-7630(eISSN)
한국동물위생학회 (The Korean Society of Veterinary Service)
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항톡소포자충 효과를 가진 천연물 유래 추출물에 관한 연구

Anti-Toxoplasmosis effects of herbal extracts against Toxoplasma Gondii

  • 홍선화 (원광대학교 동물자원개발연구센터) ;
  • 이현아 (원광대학교 동물자원개발연구센터) ;
  • 정영호 (중부대학교 애완동물자원학과) ;
  • 김태완 (경북대학교 수의과대학) ;
  • 김옥진 (원광대학교 동물자원개발연구센터)
  • Hong, Sunhwa (Center for Animal Resource Development, Wonkwang University) ;
  • Lee, Hyun-A (Center for Animal Resource Development, Wonkwang University) ;
  • Chung, Yung-Ho (Department of Companion Animal and Animal Resources Science, Joongbu University) ;
  • Kim, Tae-Wan (College of Veterinary Medicine, Kyungpook National University) ;
  • Kim, Okjin (Center for Animal Resource Development, Wonkwang University)
  • 투고 : 2013.03.12
  • 심사 : 2014.05.21
  • 발행 : 2014.06.30
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초록

Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii, with very few therapeutic treatment options. The choices for treatment are pyrimethamine and sulfadiazine, however their utility is limited because of drug toxicity and serious side effects. In this study, ethanol extracts of 13 traditional medicines used to treat Toxoplasma gondii were tested in vitro for their anti-Toxoplasma gondii cytotoxicity. The median effective concentration ($EC_{50}$) values for the herbal extracts ranged from 173 mg/mL to 1995.35 mg/mL. In HeLa cell, the selectivity of Alpinia oxyphylla (2.75), Mucunae Caulis (2.96), Dictamnus dasycarpus (7.52) which was higher than sulfadiazine (2.08). This indicates that Alpinia oxyphylla, Mucunae Caulis, Dictamnus dasycarpus extracts may be sources of new anti-Toxoplasma gondii compounds.

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참고문헌

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