Asian Pacific Journal of Cancer Prevention

  • 제15권5호
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  • Pages.1993-1999
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Interaction of XRCC1 and XPD Gene Polymorphisms with Lifestyle and Environmental Factors Regarding Susceptibility to Lung Cancer in a High Incidence Population in North East India

  • 발행 : 2014.03.01
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초록

Background: This study aimed to explore the role of XRCC1 (Arg399Gln) and XPD (Lys751Gln) gene polymorphisms, lifestyle and environmental factors as well as their possible interactions in propensity to develop lung cancer in a population with high incidence from North East India. Materials and Methods: A total of 272 lung cancer cases and 544 controls were collected and XRCC1 (Arg399Gln) and XPD (Lys751Gln) genotypes were analyzed using a polymerase chain reaction based restriction fragment length polymorphism assay. Conditional multiple logistic regression analysis was used to calculate adjusted odds ratios and 95% confidence intervals after adjusting for confounding factors. Results: The combined Gln/Gln genotype of XRCC1 and XPD genes (OR=2.78, CI=1.05-7.38; p=0.040) was significantly associated with increased risk for lung cancer. Interaction of XRCC1Gln/Gln genotype with exposure of wood combustion (OR=2.56, CI=1.16-5.66; p=0.020), exposure of cooking oil fumes (OR=3.45, CI=1.39-8.58; p=0.008) and tobacco smoking (OR=2.54, CI=1.21-5.32; p=0.014) and interaction of XPD with betel quid chewing (OR=2.31, CI=1.23-4.32; p=0.009) and tobacco smoking (OR=2.13, CI=1.12-4.05; p=0.022) were found to be significantly associated with increased risk for lung cancer. Conclusions: Gln/Gln alleles of both XRCC1 and XPD genes appear to amplify the effects of household exposure, smoking and betel quid chewing on lung cancer risk in the study population.

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참고문헌

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  3. Geographic trends of tobacco-related cancers in Cyprus vol.13, pp.1, 2015, https://doi.org/10.1186/s12971-015-0048-5
  4. Association of a p53 Codon 72 Gene Polymorphism with Environmental Factors and Risk of Lung Cancer: a Case Control Study in Mizoram and Manipur, a High Incidence Region in North East India vol.15, pp.24, 2015, https://doi.org/10.7314/APJCP.2014.15.24.10653
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  6. Note of clarification of data in the paper titled X-ray repair cross-complementing group 1 codon 399 polymorphism and lung cancer risk: an updated meta-analysis vol.36, pp.5, 2015, https://doi.org/10.1007/s13277-015-3384-4
  7. Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India vol.37, pp.7, 2016, https://doi.org/10.1007/s13277-015-4780-5
  8. The XRCC 1 DNA repair gene modifies the environmental risk of stomach cancer: a hospital-based matched case-control study vol.17, pp.1, 2017, https://doi.org/10.1186/s12885-017-3675-9
  9. Association of 12 polymorphic variants conferring genetic risk to lung cancer in Indian population: An extensive meta-analysis vol.58, pp.9, 2017, https://doi.org/10.1002/em.22149
  10. Genetic Variant Arg399Gln G>A of XRCC1 DNA Repair Gene Enhanced Cancer Risk Among Indian Population: Evidence from Meta-analysis and Trial Sequence Analyses pp.0974-0422, 2017, https://doi.org/10.1007/s12291-017-0669-y