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Two Cases of Diagnosis and Removal of Endobronchial Hamartoma by Cryotherapy via Flexible Bronchoscopy

  • Sim, Jae Kyeom (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Choi, Jong Hyun (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Oh, Jee Youn (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Cho, Jae Young (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Moon, Eul Sun (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Min, Hye Sook (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Lee, Byung Hyun (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Park, Min Seon (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Hur, Gyu Young (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Lee, Sung Yong (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Shim, Jae Jeong (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Kang, Kyung Ho (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Min, Kyung Hoon (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine)
  • Received : 2013.10.14
  • Accepted : 2013.10.25
  • Published : 2014.03.30

Abstract

Although endobronchial hamartoma is a rare benign tumor, most patients with endobronchial hamartoma have respiratory symptoms such as obstructive pneumonia, hemoptysis, cough, or dyspnea due to bronchial obstruction. It can cause irreversible post-obstructive pulmonary destruction, thus early diagnosis and treatment is very important. Recently, there have been cases of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser and electrocautery procedures for bronchoscopic treatment of malignant or benign central airway obstruction with comparable therapeutic efficacy and few complications. Bronchoscopic cryotherapy is a newly developed technique for management of central airway obstruction. Moreover, it provides diagnostic methods with improving diagnostic yield and safety. We report two cases of endobronchial hamartoma, each diagnosed and definitively treated with bronchoscopic techniques. Endobronchial biopsy and removal was successfully performed by cryotherapy via flexible bronchoscopy without notable complications. Follow-up bronchoscopic examinations excluded residual or recurrent disease.

Keywords

References

  1. Miller SM, Bellinger CR, Chatterjee A. Argon plasma coagulation and electrosurgery for benign endobronchial tumors. J Bronchology Interv Pulmonol 2013;20:38-40. https://doi.org/10.1097/LBR.0b013e318282d3ca
  2. Mathur PN, Wolf KM, Busk MF, Briete WM, Datzman M. Fiberoptic bronchoscopic cryotherapy in the management of tracheobronchial obstruction. Chest 1996;110:718-23. https://doi.org/10.1378/chest.110.3.718
  3. Maiwand MO, Asimakopoulos G. Cryosurgery for lung cancer: clinical results and technical aspects. Technol Cancer Res Treat 2004;3:143-50. https://doi.org/10.1177/153303460400300207
  4. Murray J, Kielkowski D, Leiman G. The prevalence and age distribution of peripheral pulmonary hamartomas in adult males: an autopsy-based study. S Afr Med J 1991;79:247-9.
  5. Gjevre JA, Myers JL, Prakash UB. Pulmonary hamartomas. Mayo Clin Proc 1996;71:14-20. https://doi.org/10.4065/71.1.14
  6. Lee SH, Yoon HK, Song SH, Lee SY, Kim SC, Ahn JH, et al. Clinical analysis of pulmonary hamartoma: 29 cases. Tuberc Respir Dis 2002;53:644-9. https://doi.org/10.4046/trd.2002.53.6.644
  7. Kim SA, Um SW, Song JU, Jeon K, Koh WJ, Suh GY, et al. Bronchoscopic features and bronchoscopic intervention for endobronchial hamartoma. Respirology 2010;15:150-4. https://doi.org/10.1111/j.1440-1843.2009.01662.x
  8. Cosio BG, Villena V, Echave-Sustaeta J, de Miguel E, Alfaro J, Hernandez L, et al. Endobronchial hamartoma. Chest 2002;122:202-5. https://doi.org/10.1378/chest.122.1.202
  9. Sunna R. Chapter 33. Cryotherapy and cryodebridement. In: Ernst A, Herth FJ, editors. Principles and practice of interventional pulmonology. New York: Springer Science; 2013. p. 343-50.
  10. Morgan RK, Ernst A. Chapter 12. Cryotherapy. In: Strausz J, Bolliger CT, editors. Interventional pulmonology: European respiratory monograph. Sheffield: European Respiratory Society; 2010. p. 161-72.
  11. Ernst A, Feller-Kopman D, Becker HD, Mehta AC. Central airway obstruction. Am J Respir Crit Care Med 2004;169:1278-97. https://doi.org/10.1164/rccm.200210-1181SO
  12. Vergnon JM, Huber RM, Moghissi K. Place of cryotherapy, brachytherapy and photodynamic therapy in therapeutic bronchoscopy of lung cancers. Eur Respir J 2006;28:200-18. https://doi.org/10.1183/09031936.06.00014006
  13. Schumann C, Hetzel J, Babiak AJ, Merk T, Wibmer T, Moller P, et al. Cryoprobe biopsy increases the diagnostic yield in endobronchial tumor lesions. J Thorac Cardiovasc Surg 2010;140:417-21. https://doi.org/10.1016/j.jtcvs.2009.12.028
  14. Babiak A, Hetzel J, Krishna G, Fritz P, Moeller P, Balli T, et al. Transbronchial cryobiopsy: a new tool for lung biopsies. Respiration 2009;78:203-8. https://doi.org/10.1159/000203987

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