YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Quantitative-Structure Activity Relationship (QSAR) Model for Abuse-liability Evaluation of Designer Drugs

합성마약류의 의존성 평가를 위한 구조활성상관(QSAR) 모델 적용

  • Yun, Jaesuk (Pharmaceutical Standardization and Testing Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
  • 윤재석 (식품의약품안전처, 식품의약품안전평가원, 의약품규격연구과)
  • Received : 2013.11.08
  • Accepted : 2013.12.23
  • Published : 2014.02.28
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Abstract

In recent, the abuse of newly-emerging psychoactive drugs, ('designer drugs') is a rapidly increasing problem in Korean society. Quantitative-structure activity relationship (QSAR) is an alternative method to predict bioactivities of new abused compounds. In this study, cathinone-related new designer drugs, 4-methylbuphedrone and 4-methoxy-N,N-dimethylcathinone were tested for prediction of the bioactivity with QSAR model. The bioactivity of 4-methylbuphedrone and 4-methoxy-N,N-dimethylcathinone was similar to those of methylone. These results suggest that the prediction with QSAR model may provide scientific evidences for regulatory decision.

Keywords

References

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