Clinical and Experimental Reproductive Medicine

  • 제41권1호
  • /
  • Pages.15-20
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  • 2014
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  • 2233-8233(pISSN)
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  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
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Amelioration of lipid abnormalities by vitamin therapy in women using oral contraceptives

  • Torkzahrani, Shahnaz (Department of Midwifery, Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences & Health Services) ;
  • Heidari, Afrooz (Department of Midwifery, Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences & Health Services) ;
  • Mostafavi-pour, Zohreh (Department of Biochemistry, Shiraz University of Medical Sciences) ;
  • Ahmadi, Majid (Department of English Language, School of Paramedical Sciences, Shaheed Beheshti University of Medical Sciences) ;
  • Zal, Fatemeh (Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences)
  • 투고 : 2013.10.28
  • 심사 : 2013.01.15
  • 발행 : 2014.03.31
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초록

Objective: Combined oral contraceptives (COCs) have some adverse effects on the serum lipid profile. Because hyperlipidemia is one of the risk factors in cardiovascular diseases, lipid abnormalities should be evaluated in women consuming COCs. Vitamins E and C are known to have beneficial effects on serum lipid profiles. Therefore, in this study, we evaluated the effects of vitamins E and C on serum lipids in women using COCs. Methods: The study compared changes in lipid parameters with and without vitamin therapy in women consuming COCs compared to those of a control group (40 non-contraceptive users or NCU) for 4 weeks. Total cholesterol and triglyceride, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels along with HDL/LDL ratios were measured for all participants. Results: COC users experienced significantly higher increases in the levels of triglycerides and LDL than non-users (p<0.05). However, no significant differences were noted in the total cholesterol and HDL levels. In the treated COC group receiving vitamins E and C, the HDL level and the HDL/LDL ratio increased and the LDL and triglycerides levels decreased significantly compared with those of the other groups. Conclusion: The results of our study indicate that supplementation with antioxidant vitamins E and C restores a normal lipid profile in COC users.

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  2. Oral Contraceptive Use May Modulate Global Genomic DNA Methylation and Promoter Methylation of APC1 and ESR1 vol.18, pp.9, 2014, https://doi.org/10.22034/apjcp.2017.18.9.2361