Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Spatial Analysis of Colorectal Cancer Cases in Kuala Lumpur

  • Shah, Shamsul Azhar (Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia) ;
  • Neoh, Hui-Min (UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia) ;
  • Syed Abdul Rahim, Syed Sharizman (Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia) ;
  • Azhar, Zahir Izuan (Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia) ;
  • Hassan, Mohd Rohaizat (Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia) ;
  • Safian, Nazarudin (Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia) ;
  • Jamal, Rahman (UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia)
  • Published : 2014.02.01
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Abstract

Background: In Malaysia, data from the Malaysian Health Ministry showed colorectal cancer (CRC) to be the second most common type of cancer in 2007-2009, after breast cancer. The same was apparent after looking at males and females cases separately. In the present study, the Geographic Information System (GIS) was employed to describe the distribution of CRC cases in Kuala Lumpur (KL), Malaysia, according to socio-demographic factors (age, gender, ethnicity and district). Materials and Methods: This retrospective review concerned data for patients diagnosed with colorectal cancer in the years 1995 to 2011 collected from the Wilayah Persekutuan Health Office, taken from the cancer notification form (NCR-2), and patient medical records from the Surgical Department, Universiti Kebangsaan Malaysia Medical Centre (UKMMC). A total of 146 cases were analyzed. All the data collected were analysed using ArcGIS version 10.0 and SPSS version 19.0. Results: Patients aged 60 to 69 years accounted for the highest proportion of cases (34.2%) and males slightly predominated 76 (52.1%), Chinese had the highest number of registered cases at 108 (74.0%) and staging revealed most cases in the 3rd and 4th stages. Kernel density analysis showed more cases are concentrated up in the northern area of Petaling and Kuala Lumpur subdistricts. Spatial global pattern analysis by average nearest neighbour resulted in nearest neighbour ratio of 0.75, with Z-score of -5.59, p value of <0.01 and the z-score of -5.59. Spatial autocorrelation (Moran's I) showed clustering significant with p<0.01, Z score 3.14 and Moran's Index of 0.007. When mapping clusters with hotspot analysis (Getis-Ord Gi), hot and cold spots were identified. Hot spot areas fell on the northeast side of KL. Conclusions: This study demonstrated significant spatial patterns of cancer incidence in KL. Knowledge about these spatial patterns can provide useful information to policymakers in the planning of screening of CRC in the targeted population and improvement of healthcare facilities to provide better treatment for CRC patients.

Keywords

References

  1. American Cancer Society (2011). Global Cancer Facts & Figures 2nd Edition. Atlanta, GA: American Cancer Society.
  2. American Cancer Society (2012). Cancer and Fact Figures 2012. Atlanta, GA: American Cancer Society.
  3. Bingham SA, Day NE, Luben R, et al (2003). Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet, 361, 1496-501 https://doi.org/10.1016/S0140-6736(03)13174-1
  4. Center MM, Jemal A, Ward E (2009). International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers Prev, 18, 1688-94. https://doi.org/10.1158/1055-9965.EPI-09-0090
  5. Elferink MAG, Pukkala E, Klaase JM, et al (2012). Spatial variation in stage distribution in colorectal cancer in the Netherlands. Eur J Cancer, 48, 1119-25. https://doi.org/10.1016/j.ejca.2011.06.058
  6. Fukuda Y, Umezaki M, Nakamura K, et al (2005). Variations in societal characteristics of spatial disease clusters: Examples of colon, lung and breast cancer in Japan. Int J Health Geogr, 4, 16. https://doi.org/10.1186/1476-072X-4-16
  7. Goh KL, Quek KF, Yeo GTS, et al (2005). Colorectal cancer in Asians: a demographic and anatomic survey in Malaysian patients undergoing colonoscopy. Aliment Pharmacol Ther, 22, 859-64. https://doi.org/10.1111/j.1365-2036.2005.02646.x
  8. Graves BA (2008). Integrative literature review: a review of literature related to geographical information systems, healthcare access, and health outcomes. Perspect Health Inf Manag, 5, 11.
  9. Gregorio DI, Samociuk H, DeChello L, et al (2006). Effects of study area size on geographic characterizations of health events: Prostate cancer incidence in Southern New England, USA, 1994-1998. Int J Health Geogr, 5, 8. https://doi.org/10.1186/1476-072X-5-8
  10. Holt PR, Kozuch P, Mewar S (2009). Colon cancer and the elderly: From screening to treatment in management of GI disease in the elderly. Best Pract Res Clin Gastroenterol, 23, 889-907. https://doi.org/10.1016/j.bpg.2009.10.010
  11. Hutter C, Slattery M, Duggan D, et al (2010). Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis. BMC Cancer, 10, 670. https://doi.org/10.1186/1471-2407-10-670
  12. Larsson SC, Wolk A (2006). Meat consumption and risk of colorectal cancer: a meta-analysis of prospective studies. Int J Cancer, 119, 2657-64. https://doi.org/10.1002/ijc.22170
  13. Lim GCC, Halimah Y, Lim TO (2003). The first report of the National Cancer Registry: Cancer incidence in Malaysia 2002. Kuala Lumpur: National Cancer Registry of Malaysia.
  14. Malaysia Oncological Society (2006). Colorectal cancer. Kuala Lumpur: Malaysian Oncological Society.
  15. Ministry of Health Malaysia (2009). Annual Report 2009. Kuala Lumpur: Ministry of Health Malaysia.
  16. Ministry of Health Malaysia (2006). Malaysia Cancer Statistics: Data and figure 2006. Kuala Lumpur: Ministry of Health Malaysia.
  17. Mohebbi M, Mahmoodi M, Wolfe R, et al (2008). Geographical spread of gastrointestinal tract cancer incidence in the Caspian Sea region of Iran: spatial analysis of cancer registry data. BMC Cancer, 8, 137. https://doi.org/10.1186/1471-2407-8-137
  18. Morrison DS, Batty GD, Kivimaki M, et al (2011). Risk factors for colonic and rectal cancer mortality: Evidence from 40 years follow-up in the Whitehall I study. J Epidemiol Community Health, 65, 1053-8. https://doi.org/10.1136/jech.2010.127555
  19. Mosavi-Jarrahi A, Moini M, Mohagheghi MA, et al (2007). Clustering of childhood cancer in the inner city of Tehran metropolitan area: A GIS-based analysis. Int J Hyg Environ Health, 210, 113-9. https://doi.org/10.1016/j.ijheh.2006.08.005
  20. Murphy G, Devesa SS, Cross AJ, et al (2011). Sex disparities in colorectal cancer incidence by anatomic subsite, race and age. Int J Cancer, 128, 1668-75. https://doi.org/10.1002/ijc.25481
  21. Narimah S, Dina J, Norul Shahira M (2010). Using a geographic information system (GIS) in evaluating the accessibility of health facilities for breast cancer patients in Penang state, Malaysia. Kajian Malaysia, 28, 103-22.
  22. Norat T, Bingham S, Ferrari P, et al (2005). Meat, fish, and colorectal cancer risk: The European Prospective Investigation into cancer and nutrition. J Natl Cancer Inst, 97, 906-91. https://doi.org/10.1093/jnci/dji164
  23. Ollberding NJ, Nomura AM, Wilkens LR, et al (2011). Racial/ethnic differences in colorectal cancer risk: the multiethnic cohort study. Int J Cancer, 129, 1899-906. https://doi.org/10.1002/ijc.25822
  24. Osias GL, Osias KB, Srinivasan R (2001). Colorectal cancer in women: An equal opportunity disease. J Am Osteopath Assoc, 101, 7-12.
  25. Payne S (2007). Not an equal opportunity disease-a sex and gender-based review of colorectal cancer in men and women: Part I Review Article. The Journal of Men's Health & Gender, 4, 131-9. https://doi.org/10.1016/j.jmhg.2007.03.005
  26. Pollack LA, Gotway CA, Bates JH, et al (2006). Use of the Spatial Scan Statistic to Identify Geographic Variations in Late Stage Colorectal Cancer in California (United States). Cancer Causes Control, 17, 449-57. https://doi.org/10.1007/s10552-005-0505-1
  27. Rohani-Rasaf M, Abdollahi M, Jazayeri S, et al (2013). Correlation of cancer incidence with diet, smoking and socio- economic position across 22 districts of Tehran in 2008. Asian Pac J Cancer Prev, 14, 1669-76. https://doi.org/10.7314/APJCP.2013.14.3.1669
  28. Rushton G, Peleg I, Banerjee A, et al (2004). Analyzing geographic patterns of disease incidence: Rates of late-stage colorectal cancer in Iowa. J Med Syst, 28, 223-36. https://doi.org/10.1023/B:JOMS.0000032841.39701.36
  29. Slattery ML, Benson J, Berry TD, et al (1997). Dietary sugar and colon cancer. Cancer Epidemiol Biomarkers Prev, 6, 677-85.
  30. Sung JJ, Lau JY, Goh KL, et al (2005). Increasing incidence of colorectal cancer in Asia: Implications for screening. Lancet Oncol, 6, 871. https://doi.org/10.1016/S1470-2045(05)70422-8
  31. Ulrich C, Kampman E, Bigler J, et al (1999). Colorectal adenomas and the C677T MTHFR polymorphism: Evidence for gene-environment interaction? Cancer Epidemiol Biomarkers Prev, 8, 659-68.

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