DOI QR코드

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TMPRSS2:ETS Fusions and Clinicopathologic Characteristics of Prostate Cancer Patients from Eastern China

  • Dong, Jun (Department of Urology, Huadong Hospital, Fudan University) ;
  • Xiao, Li (Department of Pathology, Huadong Hospital, Fudan University) ;
  • Sheng, Lu (Department of Urology, Huadong Hospital, Fudan University) ;
  • Xu, Jun (Department of Urology, Huadong Hospital, Fudan University) ;
  • Sun, Zhong-Quan (Department of Urology, Huadong Hospital, Fudan University)
  • 발행 : 2014.04.01

초록

TMPRSS2:ERG gene fusions in prostate cancer have a dominant prevalence of approximately 50.0%, but infomration is limited on differences among ethnic and geographical groups. Some studies focusing on Japanese and Korean patients reported a lower incidence. Investigations concerning Chinese revealed controversial results. We evaluated TMPRSS2:ERG, TMPRSS2:ETV1 and TMPRSS2:ETV4 fusions in more than 100 Eastern Chinese prostate cancer patients. Paraffin blocks of needle biopsy and radical prostatectomy were collected from 91 and 18 patients respectively. All patients' clinicopathologic factors were gathered. TMPRSS2:ERG, TMPRSS2:ETV1 and TMPRSS2:ETV4 fusions were tested by multi-probe fluorescence in situ hybridization (FISH) assay. TMPRSS2:ERG fusions was present in 14.3% biopsy specimens and 11.1% radical prostatectomy patients. Neither TMPRSS2:ETV1 nor TMPRSS2:ETV4 fusion was found in any case. Altogether, 13 (86.7%) TMPRSS2:ERG fusion positive cases possessed deletion pattern and 7 (46.6%) and insertion pattern. Some 5 cases had both deletion and insertion patterns. While 38.5% (5/13) patients with deletion pattern had distant metastasis, except for one metastatic case harboring both deletion and insertion, there were no patients with insertion pattern accompanied with metastasis. There were no differences between fusion positive and negative cases in the distribution of age, PSA, Gleason score and TNM stage. Eastern Chinese prostate cancer patients have a significantly low incidence of TMPRSS2:ERG fusion. They also lack TMPRSS2:ETV1 and TMPRSS2:ETV4 fusion. There are more deletion pattern than insertion pattern in TMPRSS2:ERG positive cases. Fusion positive and negative patients have no clinicopathologic factor differences.

키워드

참고문헌

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  3. TMPRSS2:ERG Gene Fusions in Prostate Cancer of West African Men and a Meta-Analysis of Racial Differences vol.186, pp.12, 2017, https://doi.org/10.1093/aje/kwx235
  4. Detection of prostate specific ETS fusion transcripts in cancer samples vol.33, pp.4, 2017, https://doi.org/10.7124/bc.000958
  5. Prostate cancer in Jordanian-Arab population: ERG status and relationship with clinicopathologic characteristics vol.471, pp.6, 2017, https://doi.org/10.1007/s00428-017-2160-9
  6. Ethnicity and ERG frequency in prostate cancer pp.1759-4820, 2017, https://doi.org/10.1038/nrurol.2017.140
  7. Predictive significance of TMRPSS2-ERG fusion in prostate cancer: a meta-analysis vol.18, pp.1, 2018, https://doi.org/10.1186/s12935-018-0672-2