Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Inflammatory Bowel Disease and Risk of Cholangiocarcinoma: Evidence from a Meta-analysis of Population-based Studies

  • Huai, Jia-Ping (Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University) ;
  • Ding, Jin (Department of Gastroenterology and Hepatology, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University) ;
  • Ye, Xiao-Hua (Department of Gastroenterology and Hepatology, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University) ;
  • Chen, Yan-Ping (Department of Gastroenterology and Hepatology, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University)
  • Published : 2014.04.30
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Abstract

Objective: Patients with inflammatory bowel disease (IBD) have an increased risk of extra-intestinal cancer, whereas its impact on cholangiocarcinoma (CC) remains unknown. The aim of this study was to obtain a reliable estimate of the risk of CC in IBD patients through a meta-analysis of clinical observational studies. Methods: Relevant studies were retrieved by searching PUBMED, EMBASE and Web of Science Databases up to Dec 2013. Four population-based case-control and two cohort studies with IBD were identified. Summary relative risk (RR) and its corresponding 95% confidence interval (CI) were calculated using a random-effects model. Potential sources of heterogeneity were detected using subgroup analyses. Results: The pooled risk estimate indicated IBD patients were at increased risk of CC (RR = 2.63, 95%CI = 1.47-4.72). Moreover, the increased risk of CC was also associated with Crohn's disease (RR = 2.69, 95%CI = 1.59-4.55) and ulcerative colitis (RR = 3.40, 95%CI = 2.50-4.62). In addition, site-specific analyses revealed that IBD patients had an increased risk of intrahepatic CC (ICC) (RR = 2.61, 95%CI = 1.72-3.95) and extrahepatic CC (ECC) (RR = 1.47, 95%CI = 1.10-1.97). Conclusions: This study suggests the risk of CC is significantly increased among IBD patients, especially in ICC cases. Further studies are warranted to enable definite conclusions to be drawn.

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References

  1. Barusrux S, Nanok C, Puthisawas W, et al (2012). Viral hepatitis B, C infection and genotype distribution among cholangiocarcinoma patients in northeast Thailand. Asian Pac J Cancer Prev, 13, 83-7.
  2. Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101. https://doi.org/10.2307/2533446
  3. Blechacz BR, Gores GJ (2008). Cholangiocarcinoma. Clin Liver Dis, 12, 131-50, ix. https://doi.org/10.1016/j.cld.2007.11.003
  4. Chang JS, Tsai CR, Chen LT (2013). Medical risk factors associated with cholangiocarcinoma in taiwan: a populationbased case-control study. PLoS One, 8, e69981. https://doi.org/10.1371/journal.pone.0069981
  5. DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  6. Egger M, Davey Smith G, Schneider M, Minder C (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  7. El-Serag HB, Engels EA, Landgren O, et al (2009). Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population-based study of U.S. veterans. Hepatology, 49, 116-23. https://doi.org/10.1002/hep.22606
  8. Erichsen R, Jepsen P, Vilstrup H, et al (2009). Incidence and prognosis of cholangiocarcinoma in Danish patients with and without inflammatory bowel disease: a national cohort study, 1978-2003. Eur J Epidemiol, 24, 513-20. https://doi.org/10.1007/s10654-009-9365-4
  9. Gatto M, Bragazzi MC, Semeraro R, et al (2010). Cholangiocarcinoma: update and future perspectives. Dig Liver Dis, 42, 253-60. https://doi.org/10.1016/j.dld.2009.12.008
  10. Hamling J, Lee P, Weitkunat R, Ambuhl M (2008). Facilitating meta-analyses by deriving relative effect and precision estimates for alternative comparisons from a set of estimates presented by exposure level or disease category. Stat Med, 27, 954-70. https://doi.org/10.1002/sim.3013
  11. Higgins JP, Thompson SG (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21, 1539-58. https://doi.org/10.1002/sim.1186
  12. Hussain SM, Al-Jashamy KA (2013). Determination of chemical composition of gallbladder stones and their association with induction of cholangiocarcinoma. Asian Pac J Cancer Prev, 14, 6257-60. https://doi.org/10.7314/APJCP.2013.14.11.6257
  13. Jacobsen BA, Fallingborg J, Rasmussen HH, et al (2006). Increase in incidence and prevalence of inflammatory bowel disease in northern Denmark: a population-based study, 1978-2002. Eur J Gastroenterol Hepatol, 18, 601-6. https://doi.org/10.1097/00042737-200606000-00005
  14. Jess T, Gamborg M, Matzen P, et al (2005). Increased risk of intestinal cancer in Crohn’s disease: a meta-analysis of population-based cohort studies. Am J Gastroenterol, 100, 2724-9. https://doi.org/10.1111/j.1572-0241.2005.00287.x
  15. Jess T, Rungoe C, Peyrin-Biroulet L (2012). Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies. Clin Gastroenterol Hepatol, 10, 639-45. https://doi.org/10.1016/j.cgh.2012.01.010
  16. Lazaridis KN, Gores GJ (2005). Cholangiocarcinoma. Gastroenterology, 128, 1655-67. https://doi.org/10.1053/j.gastro.2005.03.040
  17. Loftus EV, Jr., Harewood GC, Loftus CG, et al (2005). PSC-IBD:a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis. Gut, 54, 91-6. https://doi.org/10.1136/gut.2004.046615
  18. Luciani MG, Campregher C, Fortune JM, et al (2007). 5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint. Gastroenterology, 132, 221-35. https://doi.org/10.1053/j.gastro.2006.10.016
  19. Manwong M, Songserm N, Promthet S, et al (2013). Risk factors for cholangiocarcinoma in the lower part of northeast Thailand: a hospital-based case-control study. Asian Pac J Cancer Prev, 14, 5953-6. https://doi.org/10.7314/APJCP.2013.14.10.5953
  20. O’Toole A, Alakkari A, Keegan D, et al (2012). Primary sclerosing cholangitis and disease distribution in inflammatory bowel disease. Clin Gastroenterol Hepatol, 10, 439-41. https://doi.org/10.1016/j.cgh.2011.11.010
  21. Palmer WC, Patel T (2012). Are common factors involved in the pathogenesis of primary liver cancers? a meta-analysis of risk factors for intrahepatic cholangiocarcinoma. J Hepatol, 57, 69-76. https://doi.org/10.1016/j.jhep.2012.02.022
  22. Patel T (2006). Cholangiocarcinoma. Nat Clin Pract Gastroenterol Hepatol 3, 33-42. https://doi.org/10.1038/ncpgasthep0389
  23. Patel T (2011). Cholangiocarcinoma--controversies and challenges. Nat Rev Gastroenterol Hepatol, 8, 189-200. https://doi.org/10.1038/nrgastro.2011.20
  24. Pedersen N, Duricova D, Elkjaer M, et al (2010). Risk of extra-intestinal cancer in inflammatory bowel disease:meta-analysis of population-based cohort studies. Am J Gastroenterol, 105, 1480-7. https://doi.org/10.1038/ajg.2009.760
  25. Saich R, Chapman R (2008). Primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes in inflammatory bowel disease. World J Gastroenterol, 14, 331-7. https://doi.org/10.3748/wjg.14.331
  26. Shaib Y, El-Serag HB (2004). The epidemiology of cholangiocarcinoma. Semin Liver Dis, 24, 115-25. https://doi.org/10.1055/s-2004-828889
  27. Shaib YH, El-Serag HB, Davila JA, et al (2005). Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control study. Gastroenterology, 128, 620-6. https://doi.org/10.1053/j.gastro.2004.12.048
  28. Shivananda S, Lennard-Jones J, Logan R, et al (1996). Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (ECIBD). Gut, 39, 690-7. https://doi.org/10.1136/gut.39.5.690
  29. Songserm N, Promthet S, Wiangnon S, et al (2012). Prevalence and co-infection of intestinal parasites among Thai rural residents at high-risk of developing cholangiocarcinoma:a cross-sectional study in a prospective cohort study. Asian Pac J Cancer Prev, 13, 6175-9. https://doi.org/10.7314/APJCP.2012.13.12.6175
  30. Sripa B, Pairojkul C (2008). Cholangiocarcinoma: lessons from Thailand. Curr Opin Gastroenterol, 24, 349-56. https://doi.org/10.1097/MOG.0b013e3282fbf9b3
  31. Srivatanakul P, Honjo S, Kittiwatanachot P, et al (2010). Hepatitis viruses and risk of cholangiocarcinoma in northeast Thailand. Asian Pac J Cancer Prev, 11, 985-8.
  32. Tyson GL, El-Serag HB (2011). Risk factors for cholangiocarcinoma. Hepatology, 54, 173-84.
  33. Vind I, Riis L, Jess T, et al (2006). Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003-2005: a populationbased study from the Danish Crohn colitis database. Am J Gastroenterol, 101, 1274-82. https://doi.org/10.1111/j.1572-0241.2006.00552.x
  34. Wells G, Shea B, O'connell D, et al (2000). The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses.
  35. Welzel TM, Graubard BI, El-Serag HB, et al (2006). Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case-control study. Clin Gastroenterol Hepatol, 5, 1221-8.
  36. Welzel TM, Mellemkjaer L, Gloria G, et al (2007). Risk factors for intrahepatic cholangiocarcinoma in a low-risk population: a nationwide case-control study. Int J Cancer, 120, 638-41. https://doi.org/10.1002/ijc.22283

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