IMMUNE NETWORK

  • 제14권2호
  • /
  • Pages.89-99
  • /
  • 2014
  • /
  • 1598-2629(pISSN)
  • /
  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
권호 표지
DOI QR코드

DOI QR Code

Kinetics of IFN-${\gamma}$ and IL-17 Production by CD4 and CD8 T Cells during Acute Graft-versus-Host Disease

  • Ju, Ji-Min (Department of Biomedical Sciences, Seoul National University College of Medicine) ;
  • Lee, Hakmo (Biomedical Research Institute, Seoul National University Hospital) ;
  • Oh, Keunhee (Department of Biomedical Sciences, Seoul National University College of Medicine) ;
  • Lee, Dong-Sup (Department of Biomedical Sciences, Seoul National University College of Medicine) ;
  • Choi, Eun Young (Department of Biomedical Sciences, Seoul National University College of Medicine)
  • 투고 : 2013.12.20
  • 심사 : 2014.03.27
  • 발행 : 2014.04.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Graft-versus-host disease (GVHD) is a fatal complication that occurs after allogeneic hematopoietic stem cell transplantation. To understand the dynamics of CD4 and CD8 T cell production of IFN-${\gamma}$ and IL-17 during GVHD progression, we established a GVHD model by transplanting T cell-depleted bone marrow (TCD-BM) and purified T cells from B6 mice into irradiated BALB.B, creating an MHC-matched but minor histocompatibility (H) antigen-mismatched transplantation (B6 ${\rightarrow}$ BALB.B GVHD). Transplantation-induced GVHD was confirmed by the presence of the appropriate compositional changes in the T cell compartments and innate immune cells in the blood and the systemic secretion of inflammatory cytokines. Using this B6 ${\rightarrow}$ BALB.B GVHD model, we showed that the production of IFN-${\gamma}$ and IL-17 by CD4 T cells preceded that by CD8 T cells in the spleen, mesenteric lymph node, liver, and lung in the BALB.B GVHD host, and Th1 differentiation predated Th17 differentiation in all organs during GVHD progression. Such changes in cytokine production were based on changes in cytokine gene expression by the T cells at different time points during GVHD development. These results demonstrate that both IFN-${\gamma}$ and IL-17 are produced by CD4 and CD8 T cells but with different kinetics during GVHD progression.

키워드

참고문헌

  1. Blazar, B. R., W. J. Murphy, and M. Abedi. 2012. Advances in graft-versus-host disease biology and therapy. Nat. Rev. Immunol. 12: 443-458. https://doi.org/10.1038/nri3212
  2. Shlomchik, W. D. 2007. Graft-versus-host disease. Nat. Rev. Immunol. 7: 340-352. https://doi.org/10.1038/nri2000
  3. Filipovich, A. H., D. Weisdorf, S. Pavletic, G. Socie, J. R. Wingard, S. J. Lee, P. Martin, J. Chien, D. Przepiorka, D. Couriel, E. W. Cowen, P. Dinndorf, A. Farrell, R. Hartzman, J. Henslee-Downey, D. Jacobsohn, G. McDonald, B. Mittleman, J. D. Rizzo, M. Robinson, M. Schubert, K. Schultz, H. Shulman, M. Turner, G. Vogelsang, and M. E. Flowers. 2005. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biology of blood and marrow transplantation. Biol. Blood Marrow Transplant. 11: 945-956. https://doi.org/10.1016/j.bbmt.2005.09.004
  4. Socie, G. and B. R. Blazar. 2009. Acute graft-versus-host disease: from the bench to the bedside. Blood 114: 4327-4336. https://doi.org/10.1182/blood-2009-06-204669
  5. Sun, Y., I. Tawara, T. Toubai, and P. Reddy. 2007. Pathophysiology of acute graft-versus-host disease: recent advances. Transl. Res. 150: 197-214. https://doi.org/10.1016/j.trsl.2007.06.003
  6. Ferrara, J. L., R. Levy, and N. J. Chao. 1999. Pathophysiologic mechanisms of acute graft-vs.-host disease. Biol. Blood Marrow Transplant. 5: 347-356. https://doi.org/10.1016/S1083-8791(99)70011-X
  7. Iclozan, C., Y. Yu, C. Liu, Y. Liang, T. Yi, C. Anasetti, and X. Z. Yu. 2010. T helper17 cells are sufficient but not necessary to induce acute graft-versus-host disease. Biol. Blood Marrow Transplant. 16: 170-178. https://doi.org/10.1016/j.bbmt.2009.09.023
  8. Yi, T., Y. Chen, L. Wang, G. Du, D. Huang, D. Zhao, H. Johnston, J. Young, I. Todorov, D. T. Umetsu, L. Chen, Y. Iwakura, F. Kandeel, S. Forman, and D. Zeng. 2009. Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood 114: 3101-3112. https://doi.org/10.1182/blood-2009-05-219402
  9. Yang, Y. G., B. R. Dey, J. J. Sergio, D. A. Pearson, and M. Sykes. 1998. Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12. J. Clin. Invest. 102: 2126-2135. https://doi.org/10.1172/JCI4992
  10. Dong, C. 2008. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat. Rev. Immunol. 8: 337-348. https://doi.org/10.1038/nri2295
  11. Antonysamy, M. A, W. C. Fanslow, F. Fu, W. Li, S. Qian, A. B. Troutt, and A. W. Thomson. 1999. Evidence for a role of IL-17 in alloimmunity: a novel IL-17 antagonist promotes heart graft survival. Transplant. Proc. 31: 93. https://doi.org/10.1016/S0041-1345(98)01453-5
  12. Loong, C. C., H. G. Hsieh, W. Y. Lui, A. Chen, and C. Y. Lin. 2002. Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. J. Pathol. 197: 322-332. https://doi.org/10.1002/path.1117
  13. Serody, J. S. and G. R. Hill. 2012. The IL-17 differentiation pathway and its role in transplant outcome. Biol. Blood Marrow Transplant. 18: S56-61. https://doi.org/10.1016/j.bbmt.2011.10.001
  14. Carlson, M. J., M. L. West, J. M. Coghill, A. Panoskaltsis- Mortari, B. R. Blazar, and J. S. Serody. 2009. In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations. Blood 113: 1365-1374. https://doi.org/10.1182/blood-2008-06-162420
  15. Kappel, L. W., G. L. Goldberg, C. G. King, D. Y. Suh, O. M. Smith, C. Ligh, A. M. Holland, J. Grubin, N. M. Mark, C. Liu, Y. Iwakura, G. Heller, and M. R. van den Brink. 2009. IL-17 contributes to CD4-mediated graft-versus-host disease. Blood 113: 945-952. https://doi.org/10.1182/blood-2008-08-172155
  16. Yi, T., D. Zhao, C. L. Lin, C. Zhang, Y. Chen, I. Todorov, T. LeBon, F. Kandeel, S. Forman, and D. Zeng. 2008. Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease. Blood 112: 2101-2110. https://doi.org/10.1182/blood-2007-12-126987
  17. Yen, H. R., T. J. Harris, S. Wada, J. F. Grosso, D. Getnet, M. V. Goldberg, K. L. Liang, T. C. Bruno, K. J. Pyle, S. L. Chan, R. A. Anders, C. L. Trimble, A. J. Adler, T. Y. Lin, D. M. Pardoll, C. T. Huang, and C. G. Drake. 2009. Tc17 CD8 T cells: functional plasticity and subset diversity. J. Immunol. 183: 7161-7168. https://doi.org/10.4049/jimmunol.0900368
  18. Lai, H. Y., T. Y. Chou, C. H. Tzeng, and O. K. Lee. 2012. Cytokine profiles in various graft-versus-host disease target organs following hematopoietic stem cell transplantation. Cell Transplant. 21: 2033-2045. https://doi.org/10.3727/096368912X653110
  19. Choi, E. Y., G. J. Christianson, Y. Yoshimura, N. Jung, T. J. Sproule, S. Malarkannan, S. Joyce, and D. C. Roopenian. 2002. Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease. Blood 100: 4259-4265. https://doi.org/10.1182/blood-2002-05-1299
  20. Song, M. G., B. Kang, J. Y. Jeon, J. Chang, S. Lee, C.-K. Min, H. Youn, and E. Y. Choi. 2012. In Vivo imaging of differences in early donor cell proliferation in graft-versus-host disease hosts with different pre-conditioning doses. Mol. Cells 33: 79-86. https://doi.org/10.1007/s10059-012-2228-y
  21. Choi, J. H., H. Yoon, C.-K. Min, and E. Y. Choi. 2011. Effects of pre-conditioning dose on the immune kinetics and cytokine production in the leukocytes infiltrating GVHD tissues after MHC-matched transplantation. Immune. Netw. 11: 68-78
  22. Toubai, T., J. Tanaka, S. Paczesny, Y. Shono, P. Reddy, and M. Imamura. 2012. Role of cytokines in the pathophysiology of acute graft-versus-host disease (GVHD): are erum/plasma cytokines potential biomarkers for diagnosis of acute GVHD following allogeneic hematopoietic cell transplantation (Allo- HCT)? Curr. Stem Cell Res. Ther. 7: 229-239. https://doi.org/10.2174/157488812799859856
  23. Murai, M., H. Yoneyama, T. Ezaki, M. Suematsu, Y. Terashima, A. Harada, H. Hamada, H. Asakura, H. Ishikawa, and K. Matsushima. 2003. Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nat. Immunol. 4: 154-160. https://doi.org/10.1038/ni879
  24. Panoskaltsis-Mortari,. A, A. Price, J. R. Hermanson, E. Taras, C. Lees, J. S. Serody, and B. R. Blazar. 2004. In vivo imaging of graft-versus-host-disease in mice. Blood 103: 3590-3598. https://doi.org/10.1182/blood-2003-08-2827
  25. Beilhack, A., S. Schulz, J. Baker, G. F. Beilhack, C. B. Wieland, E. I. Herman, E. M. Baker, Y. A. Cao, C. H. Contag, and R. S. Negrin. 2005. In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets. Blood 106: 1113-1122. https://doi.org/10.1182/blood-2005-02-0509
  26. Koyama, M., R. D. Kuns, S. D. Olver, N. C. Raffelt, Y. A. Wilson, A. L. Don, K. E. Lineburg, M. Cheong, R. J. Robb, K. A. Markey, A. Varelias, B. Malissen, G. J. Hammerling, A. D. Clouston, C. R. Engwerda, P. Bhat, K. P. MacDonald, and G. R. Hill. 2011. Recipient nonhematopoietic antigen- presenting cells are sufficient to induce lethal acute graft-versus-host disease. Nat. Med. 18: 135-142. https://doi.org/10.1038/nm.2597
  27. Goker, H., I. C. Haznedaroglu, and N. J. Chao. 2001. Acute graft-vs-host disease: pathobiology and management. Exp. Hematol. 29: 259-277. https://doi.org/10.1016/S0301-472X(00)00677-9
  28. Visentainer, J. E., S. R. Lieber, L. B. Persoli, A. C. Vigorito, F. J. Aranha, K. A. de Brito Eid, G. B. Oliveira, E. C. Miranda, and C. A. de Souza. 2003. Serum cytokine levels and acute graft-versus-host disease after HLA-identical hematopoietic stem cell transplantation. Exp. Hematol. 31: 1044- 1050. https://doi.org/10.1016/j.exphem.2003.08.005
  29. Hill, G. R., J. M. Crawford, K. R. Cooke, Y. S. Brinson, L. Pan, and J. L. Ferrara. 1997. Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines. Blood 90: 3204-3213.
  30. Nishimori, H., Y. Maeda, T. Teshima, H. Sugiyama, K. Kobayashi, Y. Yamasuji, S. Kadohisa, H. Uryu, K. Takeuchi, T. Tanaka, T. Yoshino, Y. Iwakura, and M. Tanimoto. 2012. Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17. Blood 119: 285- https://doi.org/10.1182/blood-2011-01-332478
  31. Park, H., Z. Li, X. O. Yang, S. H. Chang, R. Nurieva, Y.-H. Wang, Y. Wang, L. Hood, Z. Zhu, Q. Tian, and C. Dong. 2005. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6: 1133-1141. https://doi.org/10.1038/ni1261
  32. O'Connor, R. A., C. T. Prendergast, C. A. Sabatos, C.W. Lau, M. D. Leech, D. C. Wraith, and S. M. Anderton. 2008. Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis. J. Immunol. 181: 3750-3754. https://doi.org/10.4049/jimmunol.181.6.3750
  33. Zhao, F., Y. Zhang, H. Wang, M. Jin, S. He, Y. Shi, Y. Guo, and Y. Zhang. 2011. Blockade of osteopontin reduces alloreactive $CD8^{+}$ T cell-mediated graft-versus-host disease. Blood 117: 1723-1733. https://doi.org/10.1182/blood-2010-04-281659
  34. Broady, R., J. Yu, V. Chow, A. Tantiworawit, C. Kang, K. Berg, M. Martinka, M. Ghoreishi, J. Dutz, and M. K. Levings. 2010. Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells. Blood 116: 5748- 5751. https://doi.org/10.1182/blood-2010-07-295436

피인용 문헌

  1. IFN-γ-mediated hematopoietic cell destruction in murine models of immune-mediated bone marrow failure vol.126, pp.24, 2014, https://doi.org/10.1182/blood-2015-06-652453
  2. Long-term consumption of sugar-sweetened beverage during the growth period promotes social aggression in adult mice with proinflammatory responses in the brain vol.7, pp.None, 2014, https://doi.org/10.1038/srep45693
  3. In vivo immunogenicity of bovine bone removed by a novel decellularization protocol based on supercritical carbon dioxide vol.46, pp.suppl2, 2018, https://doi.org/10.1080/21691401.2018.1457044
  4. During acute graft versus host disease CD28 deletion in donor CD8+, but not CD4+, T cells maintain antileukemia responses in mice vol.48, pp.12, 2014, https://doi.org/10.1002/eji.201847669
  5. Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen vol.9, pp.1, 2018, https://doi.org/10.1038/s41467-017-02665-z
  6. Calcineurin inhibitors suppress acute graft-versus-host disease via NFAT-independent inhibition of T cell receptor signaling vol.131, pp.11, 2014, https://doi.org/10.1172/jci147683