Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

Bilateral Later-Onset Sensorineural Deafness Diagnosed by Brainstem Auditory Evoked Response in a Border Collie

뇌간 청각유발전위 검사에 의해 진단된 보더 콜리의 양측 후발성 감각신경성난청

  • Kang, Byung-Jae (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Yongsun (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Seunghoon (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Wan Hee (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Kweon, Oh-Kyeong (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University)
  • 강병재 (서울대학교 수의과대학 수의외과학교실) ;
  • 김용선 (서울대학교 수의과대학 수의외과학교실) ;
  • 이승훈 (서울대학교 수의과대학 수의외과학교실) ;
  • 김완희 (서울대학교 수의과대학 수의외과학교실) ;
  • 권오경 (서울대학교 수의과대학 수의외과학교실)
  • Accepted : 2014.04.10
  • Published : 2014.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

A 4-year-old, intact female Border Collie was presented for evaluation of hearing impairment. Clinical, neurological, otoscopic and magnetic resonance imaging examinations were carried out to determine the cause of hearing loss, but no remarkable change was found. Then, brainstem auditory-evoked response test was performed to assess hearing loss, and the dog had a bilateral sensorineural deafness was revealed. Since possible causes of acquired hearing loss were ruled out by several examinations and history taking, bilateral later-onset deafness was suspected to be genetic and not congenital. This report suggested the possibility that dogs had inherited later-onset sensorineural deafness.

4년령의 암컷 보더 콜리가 청각장애 평가를 위해 내원하였다. 청력 소실의 원인을 확인하기 위해 임상 검사, 신경계 검사, 검이경, 자기 공명 검사법이 실시되었지만, 특별한 이상을 확인할 수 없었다. 청력 소실을 평가하기 위해 뇌간 청각유발전위 검사가 실시되었고, 양측성 감각신경성난청을 확인하였다. 여러 검사와 병력 확인을 통해 후천적 청력 소실의 가능한 원인들을 배제하여 유전성의 양측 후발성 감각신경성난청으로 잠정 진단하였다. 이 보고는 개에서도 사람에서 보고된 유전성의 후발성 감각신경성난청이 있을 수 있다는 것을 제안한다.

Keywords

References

  1. Ahlstrom L, Wilson W, Mills P. Unilateral deafness in a white Bull Terrier diagnosed by BAER assessment. Aust Vet J 2005; 83: 742-743. https://doi.org/10.1111/j.1751-0813.2005.tb11583.x
  2. Cox C. Investigation of hearing loss in dogs. In Pract 2002; 24: 494-501. https://doi.org/10.1136/inpract.24.9.494
  3. De Risio L, Lewis T, Freeman J, Stefani A, Matiasek L, Blott S. Prevalence, heritability and genetic correlations of congenital sensorineural deafness and pigmentation phenotypes in the Border Collie. Vet J 2011; 188: 286-290. https://doi.org/10.1016/j.tvjl.2010.05.012
  4. Igarashi M, Alford B, Cohn A, Saito R, Watanabe T. Inner ear anomalies in dogs. Ann Otol Rhinol Laryngol 1972; 81: 249-255. https://doi.org/10.1177/000348947208100211
  5. Lynch ED, Lee MK, Morrow JE, Welcsh PL, Leon PE, King MC. Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous. Science 1997; 278: 1315-1318. https://doi.org/10.1126/science.278.5341.1315
  6. Platt S, Freeman J, Stefani AI, Wieczorek L, Henley W. Prevalence of unilateral and bilateral deafness in border collies and association with phenotype. J Vet Intern Med 2006; 20: 1355-1362. https://doi.org/10.1111/j.1939-1676.2006.tb00751.x
  7. Schraders M, Oostrik J, Huygen PLM, Strom TM, van Wijk E, Kunst HPM, Hoefsloot LH, Cremers CWRJ, Admiraal RJC, Kremer H. Mutations in PTPRQ are a cause of auto somal-recessive nonsyndromic hearing impairment DFNB84 and associated with vestibular dysfunction. Am J Hum Genet 2010; 86: 604-610. https://doi.org/10.1016/j.ajhg.2010.02.015
  8. Sims MH. Electrodiagnostic evaluation of auditory function. Vet Clin North Am Small Anim Pract 1988; 18: 913-944. https://doi.org/10.1016/S0195-5616(88)50090-6
  9. Strain GM. Congenital deafness and its recognition. Vet Clin North Am Small Anim Prac 1999; 29: 895-907. https://doi.org/10.1016/S0195-5616(99)50079-X
  10. Strain GM. Aetiology, prevalence and diagnosis of deafness in dogs and cats. Br Vet J 1996; 152: 17-36. https://doi.org/10.1016/S0007-1935(96)80083-2
  11. Strain GM. Congenital Deafness in Dogs and Cats. Compend Contin Educ Pract Vet 1991; 13: 245-253.
  12. Strain GM, Kearney MT, Gignac IJ, Levesque DC, Nelson HJ, Tedford BL, Remsen LG. Brainstem Auditory Evoked Potential Assessment of Congenital Deafness in Dalmatians: Associations With Phenotypic Markers. J Vet Intern Med 1992; 6: 175-182. https://doi.org/10.1111/j.1939-1676.1992.tb00333.x
  13. Wilson WJ, Mills PC. Brainstem auditory-evoked response in dogs. Am J Vet Res 2005; 66: 2177-2187. https://doi.org/10.2460/ajvr.2005.66.2177
  14. Yokoyama JS, Lam ET, Ruhe AL, Erdman CA, Robertson KR, Webb AA, Williams DC, Chang ML, Hytonen MK, Lohi H, Hamilton SP, Neff MW. Variation in genes related to cochlear biology is strongly associated with adult-onset deafness in border collies. PLos Genet 2012; 8: e1002898. https://doi.org/10.1371/journal.pgen.1002898