A Case of Ependymoma in a Dog; Computed Tomography, Histopathological and Immunohistochemical Findings

개에서 발생한 뇌실막종 증례; 컴퓨터 단층영상, 조직병리학적 그리고 면역조직화학적 소견

  • Lee, Hee-Chun (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim, Na-Hyun (Department of Pathobiology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University) ;
  • Cho, Kyu-Woan (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Jung, Hae-Won (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Moon, Jong-Hyun (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim, Ji-Hyun (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Sur, Jung-Hyang (Department of Pathobiology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University) ;
  • Jung, Dong-In (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
  • 이희천 (경상대학교 수의과대학 동물의학연구소) ;
  • 김나현 (건국대학교 수의과대학 병리학교실) ;
  • 조규완 (경상대학교 수의과대학 동물의학연구소) ;
  • 정해원 (경상대학교 수의과대학 동물의학연구소) ;
  • 문종현 (경상대학교 수의과대학 동물의학연구소) ;
  • 김지현 (경상대학교 수의과대학 동물의학연구소) ;
  • 서정향 (건국대학교 수의과대학 병리학교실) ;
  • 정동인 (경상대학교 수의과대학 동물의학연구소)
  • Accepted : 2014.04.10
  • Published : 2014.04.30

Abstract

An 11-year-old intact female Maltese was referred because of 1 week history of cluster seizure episodes. Based on brain CT scan, brain tumor was strongly suspected. The patient was euthanized according to client's request and we performed necropsy after euthanasia. The gross findings of the postmortem coronal sections of the brain showed that the mass was relatively well-demarcated, reddish in colored, and was present inside the left lateral ventricle and compressed adjacent tissues. The tumor mass had 2 distinct histopathological features: perivascular pseudorosette-like structures and a whirl-like arrangement of fibrillary cells. The immunohistochemical profile showed strong GFAP positivity and moderate S-100 expression, sparsely dotted staining with Ki-67. Based on the histopathological and immunohistochemical findings, the present case diagnosed to ependymoma.

11살의 암컷 말티즈견이 1주일간의 군집성 발작을 주증상으로 내원하였다. 뇌 컴퓨터 단층영상 결과를 기초로 뇌종양이 강하게 의심되었다. 보호자의 요청에 따라 환자의 안락사를 실시하고 부검이 진행되었다. 부검 상 뇌의 가로단면의 육안적인 소견은, 붉은색의 종양덩어리가 비교적 잘 구분되어있었고 왼쪽 외측 뇌실에 위치해 있었으며 주변 조직들이 압박되어 있었다. 종양덩어리는 2가지의 독특한 조직병리학적인 소견을 보였다: 혈관주위 거짓로제트 양상의 구조와 원섬유 세포의 소용돌이 구조. 면역조직화학적 검사에서 GFAP에 대한 강한 양성, S-100에 대한 중등도의 양성, Ki-67에 대한 드문드문한 점상 염색성이 확인되었다. 조직병리학적 및 면역조직화학적 소견을 기초로 이 환자는 뇌실막종으로 진단되었다.

Keywords

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