Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Lack of Associations between Genetic Polymorphisms in GSTM1, GSTT1 and GSTP1 and Pancreatic Cancer Risk: A Multi-Institutional Case-Control Study in Japan

  • Yamada, Ikuhiro (Hepatobiliary and Pancreatic Section, Gastroenterological Division, Cancer Institute Hospital) ;
  • Matsuyama, Masato (Hepatobiliary and Pancreatic Section, Gastroenterological Division, Cancer Institute Hospital) ;
  • Ozaka, Masato (Hepatobiliary and Pancreatic Section, Gastroenterological Division, Cancer Institute Hospital) ;
  • Inoue, Dai (Hepatobiliary and Pancreatic Section, Gastroenterological Division, Cancer Institute Hospital) ;
  • Muramatsu, Yusuke (Hepatobiliary and Pancreatic Section, Gastroenterological Division, Cancer Institute Hospital) ;
  • Ishii, Hiroshi (Hepatobiliary and Pancreatic Section, Gastroenterological Division, Cancer Institute Hospital) ;
  • Junko, Ueda (Department of Public Health, Aichi Medical University School of Medicine) ;
  • Ueno, Makoto (Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center Hospital) ;
  • Egawa, Naoto (Department of Internal Medicine, Tokyo Metropolitan Matsuzawa Hospital) ;
  • Nakao, Haruhisa (Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine) ;
  • Mori, Mitsuru (Department of Public Health, Sapporo Medical University School of Medicine) ;
  • Matsuo, Keitaro (Department of Preventive Medicine, Kyushu University Faculty of Medical Science) ;
  • Nishiyama, Takeshi (Department of Public Health, Aichi Medical University School of Medicine) ;
  • Ohkawa, Shinichi (Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center Hospital) ;
  • Hosono, Satoyo (Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute) ;
  • Wakai, Kenji (Department of Preventive Medicine, Nagoya University Graduate School of Medicine) ;
  • Nakamura, Kozue (Department of Food and Nutrition, Gifu City Women's College) ;
  • Tamakoshi, Akiko (Department of Public Health, Hokkaido University Graduate School of Medicine) ;
  • Kuruma, Sawako (Department of Internal Medicine, Tokyo Metropolitan Matsuzawa Hospital) ;
  • Nojima, Masanori (Department of Public Health, Sapporo Medical University School of Medicine) ;
  • Takahashi, Mami (Central Animal Division, National Cancer Center Hospital) ;
  • Shimada, Kazuaki (Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital) ;
  • Yagyu, Kiyoko (Department of Public Health, Aichi Medical University School of Medicine) ;
  • Kikuchi, Shogo (Department of Public Health, Aichi Medical University School of Medicine) ;
  • Lin, Yingsong (Department of Public Health, Aichi Medical University School of Medicine)
  • Published : 2014.01.15
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Abstract

Background: We aimed to evaluate the role of genetic polymorphisms in tobacco carcinogen-metabolizing genes and their interactions with smoking in a hospital-based case-control study of Japanese subjects. Materials and Methods: We examine the associations of pancreatic cancer risk with genetic polymorphisms in GSTM1, GSTT1 and GSTP1, phase II enzymes that catalyze the conjugation of toxic and carcinogenic electrophilic molecules. The study population consisted of 360 patients and 400 control subjects, who were recruited from several medical facilities in Japan. Unconditional logistic regression methods were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and pancreatic cancer risk. Results: Among the control subjects, the prevalence of the GSTM1-null genotype and the GSTT1-null genotype was approximately 56% and 48%, respectively. Cases and controls were comparable in terms of GSTM1 and GSTT1 genotype distributions. Neither of the deleted polymorphisms in GSTM1 and GSTT1 was associated with the risk of pancreatic cancer, with an age- and sex-adjusted OR of 0.99 (95%CI: 0.74-1.32) for the GSTM1-null genotype, and 0.98 (95%CI: 0.73-1.31) for the GSTT1-null genotype. The OR was 0.97 (95%CI: 0.64-1.47) for individuals with the GSTM1 and GSTT1-null genotypes compared with those with the GSTM1 and GSTT1- present genotypes. No synergistic effects of smoking or GST genotypes were observed. Conclusions: Our results indicate no overall association between the GSTM1 and GSTT1 deletion polymorphisms and pancreatic cancer risk in the Japanese subjects in our study.

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References

  1. Bartsch H, Malaveille C, Lowenfels AB, et al (1998). Genetic polymorphism of N-acetyltransferases, glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase in relation to malignant and benign pancreatic disease risk. The International Pancreatic Disease Study Group. Eur J Cancer Prev, 7, 215-23. https://doi.org/10.1097/00008469-199806000-00006
  2. Ben Q, Xu M, Ning X, et al (2011). Diabetes mellitus and risk of pancreatic cancer: A meta-analysis of cohort studies. Eur J Cancer, 47, 1928-37. https://doi.org/10.1016/j.ejca.2011.03.003
  3. Carlsten C, Sagoo GS, Frodsham AJ, Burke W, Higgins JP (2008). Glutathione S-transferase M1 (GSTM1) polymorphisms and lung cancer: a literature-based systematic HuGE review and meta-analysis. Am J Epidemiol, 167, 759-74. https://doi.org/10.1093/aje/kwm383
  4. Cote ML, Chen W, Smith DW, et al (2009) Meta-and pooled analysis of GSTP1 polymorphism and lung cancer: a HUGEGSEC review. Am J Epidemiol, 169, 802-14. https://doi.org/10.1093/aje/kwn417
  5. Duell EJ (2012) Epidemiology and potential mechanisms of tobacco smoking and heavy alcohol consumption in pancreatic cancer. Mol Carcinog, 51, 40-52. https://doi.org/10.1002/mc.20786
  6. Duell EJ, Holly EA, Bracci PM, et al (2002). A population -based, case-control study of polymorphisms in carcinogenmetabolizing genes, smoking, and pancreatic adenocarcinoma risk. J Natl Cancer Inst, 94, 297-306. https://doi.org/10.1093/jnci/94.4.297
  7. Di Pietro G, Magno LA, Rios-Santos F (2010). Glutathione S-transferases: an overview in cancer research. Expert Opin Drug Metab Toxicol, 6, 153-70. https://doi.org/10.1517/17425250903427980
  8. Geisler SA, Olshan AF (2001). GSTM1, GSTT1, and the risk of squamous cell carcinoma of the head and neck: a mini-HuGE review. Am J Epidemiol, 154, 95-105. https://doi.org/10.1093/aje/154.2.95
  9. Hayes JD, Flanagan JU, Jowsey IR (2005). Glutathione transferases. Annu Rev Pharmacol Toxicol, 45, 51-88. https://doi.org/10.1146/annurev.pharmtox.45.120403.095857
  10. Hecht SS (2003). Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer, 3, 733-44. https://doi.org/10.1038/nrc1190
  11. Iodice S, Gandini S, Maisonneuve P, Lowenfels AB (2008). Tobacco and the risk of pancreatic cancer: a review and meta-analysis. Langenbecks Arch Surg, 393, 535-45. https://doi.org/10.1007/s00423-007-0266-2
  12. Jang JH, Cotterchio M, Borgida A, Gallinger S, Cleary SP (2012).Genetic variants in carcinogen-metabolizing enzymes, cigarette smoking and pancreatic cancer risk. Carcinogenesis, 33, 818-27. https://doi.org/10.1093/carcin/bgs028
  13. Jiao L, Bondy ML, Hassan MM, et al (2007). Glutathione S-transferase gene polymorphisms and risk and survival of pancreatic cancer. Cancer, 109, 840-8. https://doi.org/10.1002/cncr.22468
  14. Lin Y, Ueda J, Yagyu K, et al (2013). Association between variations in the fat mass and obesity-associated gene and pancreatic cancer risk: a case-control study in Japan. BMC Cancer, 13, 337. https://doi.org/10.1186/1471-2407-13-337
  15. Liu G, Ghadirian P, Vesprini D, et al (2000). Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma. Br J Cancer, 82, 1646-9. https://doi.org/10.1054/bjoc.2000.1221
  16. MacArthur DG, Balasubramanian S, Frankish A, et al (2012). A systematic survey of loss-of-function variants in human protein-coding genes. Science, 335, 823-8. https://doi.org/10.1126/science.1215040
  17. Moore LE, Huang WY, Chatterjee N, et al (2005). GSTM1, GSTT1, and GSTP1 polymorphisms and risk of advanced colorectal adenoma. Cancer Epidemiol Biomarkers Prev, 14, 1823-7. https://doi.org/10.1158/1055-9965.EPI-05-0037
  18. Moyer AM, Salavaggione OE, Hebbring SJ, et al. (2007). Glutathione S-transferase T1 and M1: gene sequence variation and functional genomics. Clin Cancer Res, 13, 7207-16. https://doi.org/10.1158/1078-0432.CCR-07-0635
  19. Moyer AM, Salavaggione OE, Wu TY, et al (2008). Glutathione s-transferase p1: gene sequence variation and functional genomic studies. Cancer Res, 68, 4791-801. https://doi.org/10.1158/0008-5472.CAN-07-6724
  20. Nebert DW, Dalton TP (2006). The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nat Rev Cancer, 6, 947-60. https://doi.org/10.1038/nrc2015
  21. Pompanon F, Bonin A, Bellemain E, Taberlet P (2005). Genotyping errors: causes, consequences and solutions. Nat Rev Genet, 6, 847-59. https://doi.org/10.1038/nrg1707
  22. Vrana D, Pikhart H, Mohelnikova-Duchonova B, et al (2009). The association between glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population. Mutat Res, 680, 78-81. https://doi.org/10.1016/j.mrgentox.2009.09.005
  23. White DL, Li D, Nurgalieva Z, El-Serag HB (2008). Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis. Am J Epidemiol, 167, 377-89. https://doi.org/10.1093/aje/kwm315

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