Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Dickkopf-1 Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features

  • Kaba, Mehmet (Department of Urology, Faculty of Medicine, Yuzuncu Yil University) ;
  • Pirincci, Necip (Department of Urology, Faculty of Medicine, Yuzuncu Yil University) ;
  • Benli, Erdal (Department of Urology, Faculty of Medicine, Ordu University) ;
  • Gecit, Ilhan (Department of Urology, Faculty of Medicine, Yuzuncu Yil University) ;
  • Gunes, Mustafa (Department of Urology, Faculty of Medicine, Yuzuncu Yil University) ;
  • Yuksel, Mehmet Bilgehan (Department of Urology, Faculty of Medicine, Celal Bayar University) ;
  • Tok, Adem (Department of Urology, Faculty of Medicine, Bulent Ecevit University) ;
  • Kemik, Ahu Sarbay (Department of Biochemistry, Faculty of Medicine, Istanbul University)
  • Published : 2014.01.15
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Abstract

Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.

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References

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