DOI QR코드

DOI QR Code

Null Glutathione S-transferase T1 and M1 Genotypes and Oral Cancer Susceptibility in China and India - a Meta-analysis

  • Peng, Jie (Clinical Department of Stomatology, Zhongnan Hospital of Wuhan University) ;
  • Liu, Hong-Zhou (Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University) ;
  • Zhu, You-Jia (Clinical Department of Stomatology, Zhongnan Hospital of Wuhan University)
  • 발행 : 2014.01.15

초록

Objective: Genetic variation is considered to strongly impact on detoxification of carcinogens and therefore is related to cancer risk. However, findings for the null genotypes of GSTT1 and GSTM1 have not always been consistent. Therefore the present meta-analysis was conducted. Methods: We accessed the reported study at different research areas and used various databases, including PubMed and Wanfang Med Onlion from 1990 to May 1st 2013. We calculated the odds ratio (OR), 95% confidence interval (CI) and P value for oral cancer by using Review Manager 5.1 and STATE 12. Results: We found that there was no increased oral cancer risk among subjects carrying GSTM1 and GSTT1 null genotype (OR=1.35, 95%CI=0.68-2.68, P=0.39) and (OR=1.41, 95%CI=0.72-2.77, P=0.31) in the Chinese population. In contrast, in studies in India a significant correlation between GSTM1 null genotype and oral cancer was observed (OR=1.59, 95%CI=1.20-2.11, P=0.001), but not in GSTT1 (OR=1.21, 95% CI=0.84-1.74, P=0.31). Conclusion: We discovered that GSTM1 deletion polymorphism had a significant effect on the susceptibility of oral cancer in the Indian population.

키워드

참고문헌

  1. Anantharaman D, Chaubal PM, Kannan S, et al (2007). Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator. Carcinogenesis, 28, 1455-62. https://doi.org/10.1093/carcin/bgm038
  2. Buch SC, Notani PN, Bhisey RA (2002). Polymorphism at GSTM1, GSTM3 and GSTT1 gene loci and susceptibility to oral cancer in an Indian population. Carcinogenesis, 23, 803-7. https://doi.org/10.1093/carcin/23.5.803
  3. Bathi RJ, Rao R, Mutalik S (2009). GST null genotype and antiox-idants: risk indicators for oral pre-cancer and cancer. Indian J Dent Res, 20, 298-303. https://doi.org/10.4103/0970-9290.57365
  4. Cha IH, Park JY, Chung WY, et al (2007). Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer. Yonsei Med J, 48, 233-9. https://doi.org/10.3349/ymj.2007.48.2.233
  5. Chen MK, Tsai HT, Chung TT, et al (2010). Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer. Head Neck, 32, 1079-87.
  6. Gronau S, Koenig-Greger D, Jerg M, et al (2003). GSTM1 enzyme concentration and enzyme activity in correlation to the genotype of detoxification enzymes in squamous cell carcinoma of the oral cavity. Oral Dis, 9, 62-7. https://doi.org/10.1034/j.1601-0825.2003.02866.x
  7. Guo L, Zhang C, Shi S, Guo X (2012). Correlation between smoking and the polymorphisms of cytochrome P450 1A1-Msp I and glutathi-one S-transferase T1 genes and oral cancer. Hua Xi Kou Qiang Yi Xue Za Zhi, 30, 187-91.
  8. Hayes JD, Pulford DJ (1995). The glutathioneS-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol, 30, 445-600. https://doi.org/10.3109/10409239509083491
  9. Hung HC, Chuang J, Chien YC, et al (1997). Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1; environmental factors and risk of oral cancer. Cancer Epidemiol Biomarkers Prev, 6, 901-5.
  10. Halawany HS, Jacob V, Abraham NB, Al-Maflehi N (2013). Oral cancer awareness and perception of tobacco use cessation counseling among dental students in four Asian countries. Asian Pac J Cancer Prev, 14, 3619-23. https://doi.org/10.7314/APJCP.2013.14.6.3619
  11. Jiang N, Pan J, Wang L, Duan YZ (2013). No significant association between p53 codon 72 Arg/Pro polymorphism and risk of oral cancer. Tumour Biol, 34, 587-96. https://doi.org/10.1007/s13277-012-0587-9
  12. Katoh T, Kaneko S, Kohshi K, et al (1999). Genetic polymorphisms of tobacco-and alcohol-related metabolizing enzymes and oral cavity cancer. Int J Cancer, 83, 606-9. https://doi.org/10.1002/(SICI)1097-0215(19991126)83:5<606::AID-IJC6>3.0.CO;2-P
  13. Liu CJ, Chang CS, Lui MT, et al (2005). Association of GST genotypes with age of onset and lymph node metastasis in oral squamous cell carcinoma. J Oral Pathol Med, 34, 473-7. https://doi.org/10.1111/j.1600-0714.2005.00345.x
  14. Majumder M, Sikdar N, Paul RR, et al (2005). Increased risk of oral leukoplakia and cancer among mixed tobacco users carrying XRCC1 variant haplotypes and cancer among smokers carrying two risk genotypes: one on each of two loci, GSTM3 and XRCC1 (codon 280). Cancer Epidemiol Biomarkers Prev, 14, 2106-12. https://doi.org/10.1158/1055-9965.EPI-05-0108
  15. Ma D, Du G, Tan B, et al (2011). Genetic polymorphism of GSTT1 to lung cancer patients in north Sichuan. Chin J Cancer Prev Treat, 18, 989-91.
  16. Masood N, Yasmin A, Kayani MA (2013). Genetic deletions of GSTM1 and GSTT1 in head and neck cancer:review of the literature from 2000 to 2012. Asian Pac J Cancer Prev, 14, 3535-9. https://doi.org/10.7314/APJCP.2013.14.6.3535
  17. Mondal R, Ghosh SK, Talukdar FR, Laskar RS (2013). Association of mitochondrial D-loop mutations with GSTM1and GSTT1 polymorphisms in oral carcinoma: A case control study from Northeast India. Oral Oncol, 49, 345-53. https://doi.org/10.1016/j.oraloncology.2012.11.003
  18. Menezes RF, Bergmann A, Thuler LC (2013). Alcohol consumption and risk of cancer: a systematic literature review. Asian Pac J Cancer Prev, 14, 4965-72. https://doi.org/10.7314/APJCP.2013.14.9.4965
  19. Petersen PE (2009). Oral cancer prevention and control-the approach of the World Health Organization. Oral Oncol, 45, 454-60. https://doi.org/10.1016/j.oraloncology.2008.05.023
  20. Ruwali M, Singh M, Pant MC, Parmar D (2011). Polymorphism in glutathione S-transferases: susceptibility and treatment outcome for head and neck cancer. Xenobiotica, 41, 1122-30. https://doi.org/10.3109/00498254.2011.614020
  21. Seidegard J, Vorachek WR, Pero RW, et al (1988). Hereditary differences in the expression of the human glutathione transferase active on transstilbene oxide are due to a gene deletion. Proc Natl Acad Sci USA, 85, 7293-7. https://doi.org/10.1073/pnas.85.19.7293
  22. Sato M, Sato T, Izumo T, et al (1999). Genetic polymorphism of drug-metabolizing enzymes and susceptibility to oral cancer. Carcinogenesis, 20, 1927-31. https://doi.org/10.1093/carcin/20.10.1927
  23. Sreelekha TT, Ramadas K, Pandey M, et al (2001). Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer. Oral Oncol, 37, 593-8. https://doi.org/10.1016/S1368-8375(01)00028-8
  24. Sharma A, Mishra A, Das BC, et al (2006). Genetic polymorphism at GSTM1 and GSTT1 gene loci and susceptibility to oral cancer. Neoplasma, 53, 309-15.
  25. Sugimura T, Kumimoto H, Tohnai I, et al (2006). Geneenvironment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms. J Oral Pathol Med, 35, 11-8. https://doi.org/10.1111/j.1600-0714.2005.00364.x
  26. Sharma R, Ahuja M, Panda NK, et al (2010). Combined effect of smoking and polymorphisms in tobacco carcinogenmetabolizing enzymes CYP1A1 and GSTM1 on the head and neck cancer risk in north Indians. DNA Cell Biol, 29, 441-8. https://doi.org/10.1089/dna.2009.1016
  27. Wang W, Zhao Y, Yang J, et al (2013). Cyclin D1 polymorphism and oral cancer: a meta-analysis. Mol Biol Rep, 40, 87-95. https://doi.org/10.1007/s11033-012-2025-x
  28. Xie H, Hou L, Shields PG, et al (2004). Metabolic polymorphisms, smoking, and oral cancer in Puerto Rico. Oncol Res, 14, 315-20.
  29. Yadav DS, Devi TR, Ihsan R, et al (2010). Polymorphisms of glutathione-S-transferase genes and the risk of aerodigestive tract cancers in the northeast Indian population. Genet Test Mol Biomark, 14, 715-23. https://doi.org/10.1089/gtmb.2010.0087
  30. Zheng Jiawei, Li Jinzhoug, Zhong Laiping, et al (2007). Clinical epidemiology and risk factors of oral squamous cell carcinoma: An overview. Chin J Oral Maxillofae Surg, 5, 83-90.
  31. Zhang CX, Guo L, Guo XF (2012). The research of correlation of EC-SOD and GSTM1 and smoking with oral cancer. J Hygiene Res, 41, 192-5.

피인용 문헌

  1. Glutathione S-transferase M1 Null Genotype and Hepatocellular Carcinoma Susceptibility in China and India: Evidence from an Updated Meta-analysis vol.15, pp.12, 2014, https://doi.org/10.7314/APJCP.2014.15.12.4851
  2. Lack of Any Association of GST Genetic Polymorphisms with Susceptibility to Ovarian Cancer - a Meta-analysis vol.15, pp.15, 2014, https://doi.org/10.7314/APJCP.2014.15.15.6131
  3. Glutathione S-Transferase T1 and M1 Polymorphisms and Risk of Uterine Cervical Lesions in Women from Central Serbia vol.15, pp.7, 2014, https://doi.org/10.7314/APJCP.2014.15.7.3201
  4. Tobacco carcinogen-metabolizing genes CYP1A1, GSTM1, and GSTT1 polymorphisms and their interaction with tobacco exposure influence the risk of head and neck cancer in Northeast Indian population vol.36, pp.8, 2015, https://doi.org/10.1007/s13277-015-3246-0
  5. Glutathione S-transferase T1 and M1 null genotypes and Parkinson’s disease risk: evidence from an updated meta-analysis vol.36, pp.9, 2015, https://doi.org/10.1007/s10072-015-2159-4
  6. Preliminary Study of the GSTM1 Null Polymorphism and History of Tobacco Smoking among Oral Cancer Patients in Northeastern Thailand vol.17, pp.2, 2016, https://doi.org/10.7314/APJCP.2016.17.2.739
  7. Association of CYP1A1 and GSTM1 Polymorphisms With Oral Cancer Susceptibility vol.94, pp.27, 2015, https://doi.org/10.1097/MD.0000000000000895