Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Cytogenetic and Genetic Mutation Features of de novo Acute Myeloid Leukemia in Elderly Chinese Patients

  • Su, Long (Cancer center, the First hospital, Jilin University) ;
  • Li, Xian (Department of Hematology, the General Hospital of China National Petroleum Corporation in Jilin, Beihua University) ;
  • Gao, Su-Jun (Cancer center, the First hospital, Jilin University) ;
  • Yu, Ping (Cancer center, the First hospital, Jilin University) ;
  • Liu, Xiao-Liang (Cancer center, the First hospital, Jilin University) ;
  • Tan, Ye-Hui (Cancer center, the First hospital, Jilin University) ;
  • Liu, Ying-Min (Cancer center, the First hospital, Jilin University)
  • Published : 2014.01.30
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Abstract

Objectives: The present study aimed to examine the cytogenetic and genetic mutation features of acute myeloid leukemia (AML) in elderly Chinese patients. Methods: A retrospective analysis of cytogenetics and genetic mutations was performed in 113 cases (age range 50-82 years) with de novo AML. Results: The most frequent cytogenetic abnormality was t (15;17) (q22;q21), detected in 10.0% (n = 9) of successfully analyzed cases, followed by t (8;21) (q22;q22) in 8.89% (n = 8), and complex karyotypes in 5.56% (n = 5). Those with complex karyotypes included 4 cases (4.44%) of monosomal karyotypes. The frequencies of NPM1, FLT3-ITD, c-kit, and CEBPA mutations were 27.4% (31/113), 14.5% (16/110), 5.88% (6/102), and 23.3% (7/30), respectively. The complete remission rates of patients in low, intermediate, and high risk groups were 37.5%, 48.6%, and 33.3%, respectively (${\chi}^2$ = 0.704, P = 0.703) based on risk stratification. Conclusion: Cytogenetics and genetic mutations alone may not be sufficient to evaluate the prognoses of elderly AML patients. The search for a novel model that would enable a more comprehensive evaluation of this population is therefore imperative.

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References

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