Journal of Cardiovascular Imaging

Korean Society of Echocardiography (한국심초음파학회)
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MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY FOR THE DETECTION OF CORONARY ARTERY DISEASE IN PATIENTS WITH GLOBAL HYPOKINESIS ADMITTED FOR FIRST-ONSET ACUTE HEART FAILURE: PILOT STUDY

  • Kim, Sung Eun (Cardiology Division, Kangdong Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Park, Dae-Gyun (Cardiology Division, Kangdong Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Hong, Ji Yeon (Cardiology Division, KEPCO Medical Center) ;
  • Lee, Jun Hee (Cardiology Division, Kangdong Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Han, Kyoo Rok (Cardiology Division, Kangdong Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Oh, Dong Jin (Cardiology Division, Kangdong Sacred Heart Hospital, Hallym University College of Medicine)
  • Received : 2014.05.31
  • Accepted : 2014.09.01
  • Published : 2014.09.27
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Abstract

BACKGROUND: The non-invasive differentiation of ischemic and nonischemic acute heart failure (AHF) not resulting from acute myocardial infarction is difficult and has therapeutic and prognostic implications. The aim of this study was to assess whether resting myocardial contrast echocardiography (MCE) can detect coronary artery disease (CAD) in patients with decreased left ventricular (LV) systolic function and global hypokinesis presenting with AHF. METHODS: Twenty-one consecutive patients underwent low-power real-time MCE based on color-coded pulse inversion Doppler. Standard apical LV views were acquired during contrast IV infusion of $Definity^{(R)}$. Following transient microbubbles destruction, the contrast replenishment rate (${\beta}$), reflecting myocardial blood flow velocity, was derived by plotting signal intensity vs. time and fitting data to the exponential function: $y(t)=A(1-e^{-{\beta}(t-t0)})+C$. RESULTS: Of the 21 (mean age $56.6{\pm}13.6$ years) patients, 5 (23.8%) demonstrated flow-limiting CAD (> 70% of luminal diameter narrowing). The mean ${\pm}$ standard deviation of LV ejection fraction was $29.6{\pm}8.6%$. Quantitative MCE analysis was feasible in 258 of 378 segments (68.3%). There were no significant difference in "${\beta}$" and "$A{\beta}$" in patients without and with CAD ($0.48{\pm}0.27$ vs. $0.45{\pm}0.25$, p = 0.453 for ${\beta}$ and $2.99{\pm}2.23$ vs. $3.68{\pm}3.13$, p = 0.059 for $A{\beta}$, respectively). No contrast-related side effects were reported. CONCLUSION: Resting quantitative MCE analysis in patients with AHF was feasible, however, the parameters did not aid in detecting of CAD.

Keywords

Acknowledgement

Supported by : Korean Society of Echocardiography

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