Journal of Cardiovascular Imaging

  • 제22권3호
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  • Pages.101-110
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  • 2014
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  • 2586-7210(pISSN)
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  • 2586-7296(eISSN)
한국심초음파학회 (Korean Society of Echocardiography)
권호 표지
DOI QR코드

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A PRIMER ON THE METHODS AND APPLICATIONS FOR CONTRAST ECHOCARDIOGRAPHY IN CLINICAL IMAGING

  • Seol, Sang-Hoon (Knight Cardiovascular Institute, Oregon Health & Science University) ;
  • Lindner, Jonathan R. (Knight Cardiovascular Institute, Oregon Health & Science University)
  • 투고 : 2014.09.10
  • 심사 : 2014.09.14
  • 발행 : 2014.09.27
⟨ 이전 논문 다음 논문 ⟩

초록

Contrast echocardiography is broadly described as a variety of techniques whereby the blood pool on cardiac ultrasound is enhanced with encapsulated gas-filled microbubbles or other acoustically active nano- or microparticles. The development of this technology has occurred primarily in response to the need improve current diagnostic applications of echocardiography such as the need to better define left ventricular cavity volumes, regional wall motion, or the presence or absence of masses and thrombi. A secondary reason for the development of contrast echocardiography has been to expand the capabilities of echocardiography. These new applications include myocardial perfusion imaging for detection of ischemia and viability, perfusion imaging of masses/tumors, and molecular imaging. The ability to fill all of these current and future clinical roles has been predicated on the ability to produce robust contrast signal which, in turn, has relied on technical innovation with regards to the microbubble contrast agents and the ultrasound imaging paradigms. In this review, we will discuss the basics of contrast echocardiography including the composition of microbubble contrast agents, the unique imaging methods used to optimize contrast signal-to-noise ratio, and the clinical applications of contrast echocardiography that have made a clinical impact.

키워드

과제정보

연구 과제 주관 기관 : National Institutes of Health

참고문헌

  1. Kaufmann BA, Wei K, Lindner JR. Contrast echocardiography. Curr Probl Cardiol 2007;32:51-96. https://doi.org/10.1016/j.cpcardiol.2006.10.004
  2. Hoffmann R, von Bardeleben S, ten Cate F, Borges AC, Kasprzak J, Firschke C, Lafitte S, Al-Saadi N, Kuntz-Hehner S, Engelhardt M, Becher H, Vanoverschelde JL. Assessment of systolic left ventricular function: a multi-centre comparison of cineventriculography, cardiac magnetic resonance imaging, unenhanced and contrast-enhanced echocardiography. Eur Heart J 2005;26:607-16.
  3. Thomson HL, Basmadjian AJ, Rainbird AJ, Razavi M, Avierinos JF, Pellikka PA, Bailey KR, Breen JF, Enriquez-Sarano M. Contrast echocardiography improves the accuracy and reproducibility of left ventricular remodeling measurements: a prospective, randomly assigned, blinded study. J Am Coll Cardiol 2001;38:867-75. https://doi.org/10.1016/S0735-1097(01)01416-4
  4. Reilly JP, Tunick PA, Timmermans RJ, Stein B, Rosenzweig BP, Kronzon I. Contrast echocardiography clarifies uninterpretable wall motion in intensive care unit patients. J Am Coll Cardiol 2000;35:485-90. https://doi.org/10.1016/S0735-1097(99)00558-6
  5. Kurt M, Shaikh KA, Peterson L, Kurrelmeyer KM, Shah G, Nagueh SF, Fromm R, Quinones MA, Zoghbi WA. Impact of contrast echocardiography on evaluation of ventricular function and clinical management in a large prospective cohort. J Am Coll Cardiol 2009;53:802-10. https://doi.org/10.1016/j.jacc.2009.01.005
  6. Thavendiranathan P, Grant AD, Negishi T, Plana JC, Popovic ZB, Marwick TH. Reproducibility of echocardiographic techniques for sequential assessment of left ventricular ejection fraction and volumes: application to patients undergoing cancer chemotherapy. J Am Coll Cardiol 2013;61:77-84. https://doi.org/10.1016/j.jacc.2012.09.035
  7. Plana JC, Mikati IA, Dokainish H, Lakkis N, Abukhalil J, Davis R, Hetzell BC, Zoghbi WA. A randomized cross-over study for evaluation of the effect of image optimization with contrast on the diagnostic accuracy of dobutamine echocardiography in coronary artery disease The OPTIMIZE Trial. JACC Cardiovasc Imaging 2008;1:145-52. https://doi.org/10.1016/j.jcmg.2007.10.014
  8. Thanigaraj S, Nease RF Jr, Schechtman KB, Wade RL, Loslo S, Perez JE. Use of contrast for image enhancement during stress echocardiography is cost-effective and reduces additional diagnostic testing. Am J Cardiol 2001;87:1430-2. https://doi.org/10.1016/S0002-9149(01)01573-9
  9. Crouse LJ, Cheirif J, Hanly DE, Kisslo JA, Labovitz AJ, Raichlen JS, Schutz RW, Shah PM, Smith MD. Opacification and border delineation improvement in patients with suboptimal endocardial border definition in routine echocardiography: results of the Phase III Albunex Multicenter Trial. J Am Coll Cardiol 1993;22:1494-500. https://doi.org/10.1016/0735-1097(93)90562-F
  10. Rainbird AJ, Mulvagh SL, Oh JK, McCully RB, Klarich KW, Shub C, Mahoney DW, Pellikka PA. Contrast dobutamine stress echocardiography: clinical practice assessment in 300 consecutive patients. J Am Soc Echocardiogr 2001;14:378-85. https://doi.org/10.1067/mje.2001.111264
  11. Siebelink HM, Scholte AJ, Van de Veire NR, Holman ER, Nucifora G, van der Wall EE, Bax JJ. Value of contrast echocardiography for left ventricular thrombus detection postinfarction and impact on antithrombotic therapy. Coron Artery Dis 2009;20:462-6. https://doi.org/10.1097/MCA.0b013e328330d58f
  12. Bezante GP, Chen X, Molinari G, Valbusa A, Deferrari L, Sebastiani V, Yokoyama N, Steinmetz S, Barsotti A, Schwarz KQ. Left ventricular myocardial mass determination by contrast enhanced colour Doppler compared with magnetic resonance imaging. Heart 2005;91:38-43. https://doi.org/10.1136/hrt.2003.023234
  13. Soman P, Swinburn J, Callister M, Stephens NG, Senior R. Apical hypertrophic cardiomyopathy: bedside diagnosis by intravenous contrast echocardiography. J Am Soc Echocardiogr 2001;14:311-3. https://doi.org/10.1067/mje.2001.108475
  14. Moon JC, Fisher NG, McKenna WJ, Pennell DJ. Detection of apical hypertrophic cardiomyopathy by cardiovascular magnetic resonance in patients with non-diagnostic echocardiography. Heart 2004;90:645-9. https://doi.org/10.1136/hrt.2003.014969
  15. Koo BK, Choi D, Ha JW, Kang SM, Chung N, Cho SY. Isolated noncompaction of the ventricular myocardium: contrast echocardiographic findings and review of the literature. Echocardiography 2002;19:153-6. https://doi.org/10.1046/j.1540-8175.2002.00153.x
  16. Kassab GS, Lin DH, Fung YC. Morphometry of pig coronary venous system. Am J Physiol 1994;267(6 Pt 2):H2100-13.
  17. Lindner JR, Villanueva FS, Dent JM, Wei K, Sklenar J, Kaul S. Assessment of resting perfusion with myocardial contrast echocardiography: theoretical and practical considerations. Am Heart J 2000;139(2 Pt 1):231-40. https://doi.org/10.1016/S0002-8703(00)90231-X
  18. Balcells E, Powers ER, Lepper W, Belcik T, Wei K, Ragosta M, Samady H, Lindner JR. Detection of myocardial viability by contrast echocardiography in acute infarction predicts recovery of resting function and contractile reserve. J Am Coll Cardiol 2003;41:827-33. https://doi.org/10.1016/S0735-1097(02)02962-5
  19. Main ML, Magalski A, Chee NK, Coen MM, Skolnick DG, Good TH. Full-motion pulse inversion power Doppler contrast echocardiography differentiates stunning from necrosis and predicts recovery of left ventricular function after acute myocardial infarction. J Am Coll Cardiol 2001;38:1390-4. https://doi.org/10.1016/S0735-1097(01)01574-1
  20. Shimoni S, Frangogiannis NG, Aggeli CJ, Shan K, Quinones MA, Espada R, Letsou GV, Lawrie GM, Winters WL, Reardon MJ, Zoghbi WA. Microvascular structural correlates of myocardial contrast echocardiography in patients with coronary artery disease and left ventricular dysfunction: implications for the assessment of myocardial hibernation. Circulation 2002;106:950-6. https://doi.org/10.1161/01.CIR.0000026395.19594.43
  21. Janardhanan R, Moon JC, Pennell DJ, Senior R. Myocardial contrast echocardiography accurately reflects transmurality of myocardial necrosis and predicts contractile reserve after acute myocardial infarction. Am Heart J 2005;149:355-62. https://doi.org/10.1016/j.ahj.2004.06.018
  22. Rinkevich D, Kaul S, Wang XQ, Tong KL, Belcik T, Kalvaitis S, Lepper W, Dent JM, Wei K. Regional left ventricular perfusion and function in patients presenting to the emergency department with chest pain and no ST-segment elevation. Eur Heart J 2005;26:1606-11. https://doi.org/10.1093/eurheartj/ehi335
  23. Tong KL, Kaul S, Wang XQ, Rinkevich D, Kalvaitis S, Belcik T, Lepper W, Foster WA, Wei K. Myocardial contrast echocardiography versus Thrombolysis In Myocardial Infarction score in patients presenting to the emergency department with chest pain and a nondiagnostic electrocardiogram. J Am Coll Cardiol 2005;46:920-7. https://doi.org/10.1016/j.jacc.2005.03.076
  24. Kaul S, Pandian NG, Guerrero JL, Gillam LD, Okada RD, Weyman AE. Effects of selectively altering collateral driving pressure on regional perfusion and function in occluded coronary bed in the dog. Circ Res 1987;61:77-85. https://doi.org/10.1161/01.RES.61.1.77
  25. Piek JJ, Becker AE. Collateral blood supply to the myocardium at risk in human myocardial infarction: a quantitative postmortem assessment. J Am Coll Cardiol 1988;11:1290-6. https://doi.org/10.1016/0735-1097(88)90294-X
  26. Levin DC. Pathways and functional significance of the coronary collateral circulation. Circulation 1974;50:831-7. https://doi.org/10.1161/01.CIR.50.4.831
  27. Verma S, Fedak PW, Weisel RD, Butany J, Rao V, Maitland A, Li RK, Dhillon B, Yau TM. Fundamentals of reperfusion injury for the clinical cardiologist. Circulation 2002;105:2332-6. https://doi.org/10.1161/01.CIR.0000016602.96363.36
  28. Elhendy A, O'Leary EL, Xie F, McGrain AC, Anderson JR, Porter TR. Comparative accuracy of real-time myocardial contrast perfusion imaging and wall motion analysis during dobutamine stress echocardiography for the diagnosis of coronary artery disease. J Am Coll Cardiol 2004;44:2185-91. https://doi.org/10.1016/j.jacc.2004.08.059
  29. Jeetley P, Hickman M, Kamp O, Lang RM, Thomas JD, Vannan MA, Vanoverschelde JL, van der Wouw PA, Senior R. Myocardial contrast echocardiography for the detection of coronary artery stenosis: a prospective multicenter study in comparison with single-photon emission computed tomography. J Am Coll Cardiol 2006;47:141-5. https://doi.org/10.1016/j.jacc.2005.08.054
  30. Shimoni S, Zoghbi WA, Xie F, Kricsfeld D, Iskander S, Gobar L, Mikati IA, Abukhalil J, Verani MS, O'Leary EL, Porter TR. Realtime assessment of myocardial perfusion and wall motion during bicycle and treadmill exercise echocardiography: comparison with single photon emission computed tomography. J Am Coll Cardiol 2001;37:741-7. https://doi.org/10.1016/S0735-1097(00)01179-7
  31. Peltier M, Vancraeynest D, Pasquet A, Ay T, Roelants V, D'hondt AM, Melin JA, Vanoverschelde JL. Assessment of the physiologic significance of coronary disease with dipyridamole real-time myocardial contrast echocardiography. Comparison with technetium-99m sestamibi single-photon emission computed tomography and quantitative coronary angiography. J Am Coll Cardiol 2004;43:257-64. https://doi.org/10.1016/j.jacc.2003.07.040
  32. Wei K, Crouse L, Weiss J, Villanueva F, Schiller NB, Naqvi TZ, Siegel R, Monaghan M, Goldman J, Aggarwal P, Feigenbaum H, DeMaria A. Comparison of usefulness of dipyridamole stress myocardial contrast echocardiography to technetium-99m sestamibi single-photon emission computed tomography for detection of coronary artery disease (PB127 Multicenter Phase 2 Trial results). Am J Cardiol 2003;91:1293-8. https://doi.org/10.1016/S0002-9149(03)00316-3
  33. Leong-Poi H, Coggins MP, Sklenar J, Jayaweera AR, Wang XQ, Kaul S. Role of collateral blood flow in the apparent disparity between the extent of abnormal wall thickening and perfusion defect size during acute myocardial infarction and demand ischemia. J Am Coll Cardiol 2005;45:565-72. https://doi.org/10.1016/j.jacc.2004.11.032
  34. Dodla S, Xie F, Smith M, O'Leary E, Porter TR. Real-time perfusion echocardiography during treadmill exercise and dobutamine stress testing. Heart 2010;96:220-5. https://doi.org/10.1136/hrt.2009.168112
  35. Sboros V, Moran CM, Anderson T, McDicken WN. An in vitro comparison of ultrasonic contrast agents in solutions with varying air levels. Ultrasound Med Biol 2000;26:807-18. https://doi.org/10.1016/S0301-5629(00)00215-5
  36. de Jong N, Hoff L, Skotland T, Bom N. Absorption and scatter of encapsulated gas filled microspheres: theoretical considerations and some measurements. Ultrasonics 1992;30:95-103. https://doi.org/10.1016/0041-624X(92)90041-J
  37. Abdelmoneim SS, Mankad SV, Bernier M, Dhoble A, Hagen ME, Ness SA, Chandrasekaran K, Pellikka PA, Oh JK, Mulvagh SL. Microvascular function in Takotsubo cardiomyopathy with contrast echocardiography: prospective evaluation and review of literature. J Am Soc Echocardiogr 2009;22:1249-55. https://doi.org/10.1016/j.echo.2009.07.012
  38. Lindner JR, Womack L, Barrett EJ, Weltman J, Price W, Harthun NL, Kaul S, Patrie JT. Limb stress-rest perfusion imaging with contrast ultrasound for the assessment of peripheral arterial disease severity. JACC Cardiovasc Imaging 2008;1:343-50. https://doi.org/10.1016/j.jcmg.2008.04.001
  39. de Jong N, Frinking PJ, Bouakaz A, Goorden M, Schourmans T, Jingping X, Mastik F. Optical imaging of contrast agent microbubbles in an ultrasound field with a 100-MHz camera. Ultrasound Med Biol 2000;26:487-92. https://doi.org/10.1016/S0301-5629(99)00159-3
  40. Weissman NJ, Cohen MC, Hack TC, Gillam LD, Cohen JL, Kitzman DW. Infusion versus bolus contrast echocardiography: a multicenter, open-label, crossover trial. Am Heart J 2000;139:399-404. https://doi.org/10.1016/S0002-8703(00)90082-6
  41. Wei K, Jayaweera AR, Firoozan S, Linka A, Skyba DM, Kaul S. Basis for detection of stenosis using venous administration of microbubbles during myocardial contrast echocardiography: bolus or continuous infusion? J Am Coll Cardiol 1998;32:252-60. https://doi.org/10.1016/S0735-1097(98)00212-5
  42. Burns PN. Harmonic imaging with ultrasound contrast agents. Clin Radiol 1996;51 Suppl 1:50-5.
  43. Porter TR, Xie F, Kricsfeld D, Armbruster RW. Improved myocardial contrast with second harmonic transient ultrasound response imaging in humans using intravenous perfluorocarbon-exposed sonicated dextrose albumin. J Am Coll Cardiol 1996;27:1497-501. https://doi.org/10.1016/0735-1097(96)00017-4
  44. Senior R, Kaul S, Soman P, Lahiri A. Power doppler harmonic imaging: a feasibility study of a new technique for the assessment of myocardial perfusion. Am Heart J 2000;139(2 Pt 1):245-51. https://doi.org/10.1016/S0002-8703(00)90233-3
  45. Kuersten B, Murthy TH, Li P, Liu Z, Locricchio E, Baisch C, Rafter P, Vannan M. Ultraharmonic myocardial contrast imaging: in vivo experimental and clinical data from a novel technique. J Am Soc Echocardiogr 2001;14:910-6. https://doi.org/10.1067/mje.2001.113257
  46. Simpson DH, Chin CT, Burns PN. Pulse inversion Doppler: a new method for detecting nonlinear echoes from microbubble contrast agents. IEEE Trans Ultrason Ferroelectr Freq Control 1999;46:372-82. https://doi.org/10.1109/58.753026
  47. Mor-Avi V, Caiani EG, Collins KA, Korcarz CE, Bednarz JE, Lang RM. Combined assessment of myocardial perfusion and regional left ventricular function by analysis of contrast-enhanced power modulation images. Circulation 2001;104:352-7. https://doi.org/10.1161/01.CIR.104.3.352
  48. Lindner JR, Song J, Jayaweera AR, Sklenar J, Kaul S. Microvascular rheology of Definity microbubbles after intra-arterial and intravenous administration. J Am Soc Echocardiogr 2002;15:396-403. https://doi.org/10.1067/mje.2002.117290

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