대한소아치과학회지 (Journal of the korean academy of Pediatric Dentistry)

  • 제41권2호
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  • Pages.166-173
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  • 2014
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  • 1226-8496(pISSN)
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  • 2288-3819(eISSN)
대한소아치과학회 (Korean Academy of Pediatric Dentistry)
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기저세포 모반 증후군 : 증례보고

Basal Cell Nevus Syndrome : A Case Report

  • 김지연 (한림대학교 성심병원 소아치과) ;
  • 오소희 (한림대학교 성심병원 소아치과)
  • Kim, Jeeyoun (Department of Pediatric Dentistry, Sacred Heart Hospital, Hallym University) ;
  • Oh, Sohee (Department of Pediatric Dentistry, Sacred Heart Hospital, Hallym University)
  • 투고 : 2013.11.05
  • 심사 : 2013.11.27
  • 발행 : 2014.05.30
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초록

기저세포 모반 증후군은 상염색체 우성 방식으로 유전되는 질환으로 다발성 각화낭성 치성종양, 대두증 및 두정골 융기, 골격계 기형 등을 보이는 질환이다. 다발성 각화낭성 치성 종양, 두정골 융기, 양안격리증을 가진 만 11세 환자의 하악과 상악에서 발생한 다양한 크기의 낭종에 대한 적출술과 이종골 이식술을 시행 후 교정적 견인을 시행하였다. 낭종에 의한 매복 영구치를 가진 성장중인 기저세포 모반 증후군 환자에서의 보존적인 치료를 하였기에 문헌고찰과 더불어 보고하고자 한다.

The basal cell nevus syndrome is also known as the Gorlin-Goltz syndrom. It is a dominant autosomal disorder which is characterized by keratocystic odontogenic tumors in the jaw, skeletal abnormalities, and multiple basal cell nevi carcinomas. This study reports an 11-year-old boy with multiple odontogenic keratocysts in the jaw, hypertelorism, and frontal bossing. When a young patient has cystic lesions with an impacted permanent teeth, it is important to preserve the teeth. For a growing patient with impacted permanent teeth, a more conservative method is suggested, which will enable the preservation the permanent teeth in Gorlin-Goltz syndrome.

키워드

참고문헌

  1. Gorlin RJ : Nevoid basal cell carcinoma (Gorlin) syndrome: unanswered issues. J Lab Clin Med, 134:551-552, 1999. https://doi.org/10.1016/S0022-2143(99)90092-6
  2. Nicolatou O, Kakarantza-Angelopoulou E : Odontogenic keratocysts: clinicopathologic study of 87 cases. J Oral Maxillofac Surg, 48:593-599, discussion 599-600, 1990. https://doi.org/10.1016/S0278-2391(10)80472-0
  3. Howell JB , Caro MR : The basal-cell nevus: its relationship to multiple cutaneous cancers and associated anomalies of development. AMA Arch Derm, 79:67-77, discussion 77-80, 1959. https://doi.org/10.1001/archderm.1959.01560130069008
  4. Gorlin RJ : Nevoid basal cell carcinoma syndrome. Dermatol Clin, 13:113-25, 1995.
  5. Howell JB, Anderson DE :"The basal-cell nevus"by Howell and Caro, January 1959. Commentary: The nevoid basal cell carcinoma syndrome. Arch Dermatol, 118:813-826, 1982. https://doi.org/10.1001/archderm.1982.01650220117017
  6. Ahn SG, Lim YS, Kim DK, et al. : Nevoid basal cell carcinoma syndrome: a retrospective analysis of 33 affected Korean individuals. Int J Oral Maxillofac Surg, 33:458-462. 2004. https://doi.org/10.1016/j.ijom.2003.11.001
  7. Evans DG , Ladusans EJ , Rimmer S, et al. : Complications of the nevoid basal cell carcinoma syndrome: results of a population based study. J Med Genet, 30:460-464, 1993. https://doi.org/10.1136/jmg.30.6.460
  8. Southwick GJ, Schwartz RA : The basal cell nevus syndrome: disasters occurring among a series of 36 patients. Cancer, 44:2294-2305, 1979. https://doi.org/10.1002/1097-0142(197912)44:6<2294::AID-CNCR2820440644>3.0.CO;2-G
  9. Stoelinga PJ, Peters JH, van de Staak WJ, et al. : Some new findings in the basal-cell nevus syndrome. Oral Surg Oral Med Oral Pathol, 36:686-692, 1973. https://doi.org/10.1016/0030-4220(73)90141-2
  10. Myoung H, Hong SP, Hong SD, et al. : Odontogenic keratocyst: Review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 91:328-333, 2001. https://doi.org/10.1067/moe.2001.113109
  11. Gorlin RJ, Sedano HO : The multiple nevoid basal cell carcinoma syndrome revisited. Birth Defects Orig Artic Ser, 7:140-148, 1971.
  12. Howell JB : Nevoid basal cell carcinoma syndrome. Profile of genetic and environmental factors in oncogenesis. J Am Acad Dermatol, 11:98-104, 1984. https://doi.org/10.1016/S0190-9622(84)70141-1
  13. R Yang X, Pfeiffer RM, Goldstein AM : Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome. J Med Genet, 43:16, 2006.
  14. Cohen MM Jr : Nevoid basal cell carcinoma syndrome: molecular biology and new hypotheses. Int J Oral Maxillofac Surg, 28:216-23, 1999. https://doi.org/10.1016/S0901-5027(99)80142-8
  15. Brannon RB : The odontogenic keratocyst. A clinicopathologic study of 312 cases. Part I. Clinical features. Oral Surg Oral Med Oral Pathol, 42:54-72, 1976. https://doi.org/10.1016/0030-4220(76)90031-1
  16. Nakamura, N, Mitsuyasu T, Mitsuyasu Y, et al. : Marsupialization for odontogenic keratocysts: longterm follow-up analysis of the effects and changes in growth characteristics. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 94:543-553, 2002. https://doi.org/10.1067/moe.2002.128022
  17. Pogrel MA : Decompression and marsupialization as a treatment for the odontogenic keratocyst. Oral Maxillofac Surg Clin North Am, 15:415-427, 2003. https://doi.org/10.1016/S1042-3699(03)00038-4
  18. Ninomiya, T, Kubota Y, Koji T, et al. : Marsupialization inhibits interleukin-1alpha expression and epithelial cell proliferation in odontogenic keratocysts. J Oral Pathol Med, 31:526-533, 2002. https://doi.org/10.1034/j.1600-0714.2002.00029.x
  19. Nakamura N, Mitsuyasu T, Mitsuyasu Y, et al. : Marsupialization for odontogenic keratocysts: longterm follow-up analysis of the effects and changes in growth characteristics. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 94:543-53, 2002. https://doi.org/10.1067/moe.2002.128022
  20. Thomas M, Tackett JC, Desai P : The incredible odontogenic keratocyst. N Y State Dent J, 58:31-3, 1992.
  21. Loescher AR, Robinson PP : The effect of surgical medicaments on peripheral nerve function. Br J Oral Maxillofac Surg, 36:327-32, 1998. https://doi.org/10.1016/S0266-4356(98)90642-8
  22. Valentini P, Abensur D, Densari D, et al. : Histological evaluation of Bio-Oss in a 2-stage sinus floor elevation and implantation procedure. A human case report. Clin Oral Implants Res, 9:59-64, 1998. https://doi.org/10.1034/j.1600-0501.1998.090108.x
  23. Goudy S, Lott D, Burton R, et al. : Secondary alveolar bone grafting: outcomes, revisions, and new applications. Cleft Palate Craniofac J, 46:610-612, 2009. https://doi.org/10.1597/08-126.1
  24. Boyne PJ : Application of bone morphogenetic proteins in the treatment of clinical oral and maxillofacial osseous defects. J Bone Joint Surg Am, 83:146-150, 2001.