Journal of Korean Neurosurgical Society

  • 제55권2호
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  • Pages.89-91
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  • 2014
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  • 2005-3711(pISSN)
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  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
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Chronic Encapsulated Intracerebral Hematoma Associated with Cavernous Malformation

  • Takeuchi, Satoru (Department of Neurosurgery, National Defense Medical College) ;
  • Wada, Kojiro (Department of Neurosurgery, National Defense Medical College) ;
  • Sakakibara, Fumihiro (Department of Neurosurgery, National Defense Medical College) ;
  • Mori, Kentaro (Department of Neurosurgery, National Defense Medical College)
  • 투고 : 2012.07.27
  • 심사 : 2014.01.10
  • 발행 : 2014.02.28
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초록

Chronic encapsulated intracerebral hematoma (CEIH) is a rare cerebrovascular disease that behaves as a slowly expanding lesion with a gradual onset. It is well established that CEIH is associated with arteriovenous malformations; however, CEIH associated with cavernous malformation (CM) is extremely rare. We herein report a case of CEIH associated with CM, and discuss its pathogenesis. A 12-year-old female was admitted to our hospital because of a one week history of progressive headache and nausea. Brain computed tomography scan and magnetic resonance imaging showed an intracerebral hematoma surrounded by edema in the right frontal lobe. One week later, her headache and nausea worsened, and a brain computed tomography scan revealed the enlargement of hematoma. A right frontal craniotomy was performed. The capsule, mass, and hematoma were totally removed. Histological examination confirmed the diagnosis of CEIH associated with CM. Immunohistochemical analysis revealed increased expression of vascular endothelial growth factor (VEGF) and the VEGF receptor-1 in the endothelium and fibroblasts. Our findings suggest that the activated VEGF pathway might have positively contributed to development of CEIH in the present patient.

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참고문헌

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피인용 문헌

  1. Chronic Encapsulated Intracerebral Hematoma : A Report of Two Cases and a Review of the Literature vol.26, pp.2, 2014, https://doi.org/10.7887/jcns.26.134
  2. Oral encapsulated vascular malformation: An undescribed presentation in the mouth vol.8, pp.1, 2016, https://doi.org/10.4317/jced.52698
  3. Imaging Diagnosis of Chronic Encapsulated Intracerebral Hematoma, a Comparison of Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) characteristics vol.82, pp.None, 2017, https://doi.org/10.12659/pjr.902417