Journal of Periodontal and Implant Science

  • 제44권2호
  • /
  • Pages.85-93
  • /
  • 2014
  • /
  • 2093-2278(pISSN)
  • /
  • 2093-2286(eISSN)
대한치주과학회 (Korean Academy of Periodontology)
권호 표지
DOI QR코드

DOI QR Code

Periodontitis among poor rural Indian mothers increases the risk of low birth weight babies: a hospital-based case control study

  • Jacob, Pulikottil Shaju (Department of Clinical Dentistry, International Medical University School of Dentistry) ;
  • Nath, Sonia (Department of Periodontology, Vananchal Dental College and Hospital)
  • 투고 : 2014.01.03
  • 심사 : 2014.02.28
  • 발행 : 2014.04.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: Low birth weight (LBW) is one of the major public health problems in India. Hence, there is a need to identify risk factors that, when modified, will reduce the burden of unhealthy children on the healthcare system. The objective of this study was to determine whether periodontitis among mothers in the rural population of India is a risk factor for LBW babies. Methods: A hospital-based case control study was conducted among 340 postpartum mothers. The cases consisted of 170 women who had given birth to babies weighing <2,500 g, while the control group consisted of 170 women who had given birth to babies weighing ${\geq}2,500g$. Details of the mothers were taken from the hospital records and through a personal interview, and a full-mouth periodontal examination was performed postpartum, which included probing depth, clinical attachment level, and bleeding on probing on six sites per tooth. Results: LBW cases had a significantly worse periodontal status than the controls, having an odds ratio (OR) of 2.94 (P=0.01). The multivariate logistic regression model demonstrated that periodontal disease is a significant independent risk factor with an adjusted odds ratio (aOR) of 2.85 for the LBW group (95% confidence interval [CI], 1.62-5.5). Other factors showing significant associations with LBW were pre-eclampsia (aOR, 4.49; 95% CI, 1.4-14.7), preterm labor (aOR, 5.5; 95% CI, 3.2-9.9), and vaginal type of delivery (aOR, 2.74; 95% CI, 1.4-5.2). Conclusions: Periodontitis represents a strong, independent, and clinically significant risk factor for LBW. Periodontal therapy should form a part of the antenatal preventive care among rural women in India.

키워드

참고문헌

  1. Million Death Study Collaborators, Bassani DG, Kumar R, Awasthi S, Morris SK, Paul VK, et al. Causes of neonatal and child mortality in India: a nationally representative mortality survey. Lancet 2010;376:1853-60. https://doi.org/10.1016/S0140-6736(10)61461-4
  2. Lorenz JM, Wooliever DE, Jetton JR, Paneth N. A quantitative review of mortality and developmental disability in extremely premature newborns. Arch Pediatr Adolesc Med 1998;152:425-35.
  3. World Health Organization. The incidence of low birth weight: an update. Wkly Epidemiol Rec 1984:59:205-11.
  4. McCormick MC. The contribution of low birth weight to infant mortality and childhood morbidity. N Engl J Med 1985;312:82-90. https://doi.org/10.1056/NEJM198501103120204
  5. da Silva TR. Nonbiological maternal risk factor for low birth weight on Latin America: a systematic review of literature with meta-analysis. Einstein (Sao Paulo) 2012;10:380-5. https://doi.org/10.1590/S1679-45082012000300023
  6. Gibbs RS. The relationship between infections and adverse pregnancy outcomes: an overview. Ann Periodontol 2001;6:153-63. https://doi.org/10.1902/annals.2001.6.1.153
  7. Page RC. The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodontal Res 1991;26(3 Pt 2):230-42. https://doi.org/10.1111/j.1600-0765.1991.tb01649.x
  8. Williams CE, Davenport ES, Sterne JA, Sivapathasundaram V, Fearne JM, Curtis MA. Mechanisms of risk in preterm low-birthweight infants. Periodontol 2000 2000;23:142-50. https://doi.org/10.1034/j.1600-0757.2000.2230115.x
  9. Sanz M, Kornman K; Working group 3 of joint EFP/AAP workshop. Periodontitis and adverse pregnancy outcomes: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol 2013;40 Suppl 14:S164-9. https://doi.org/10.1111/jcpe.12083
  10. Corbella S, Taschieri S, Francetti L, De Siena F, Del Fabbro M. Periodontal disease as a risk factor for adverse pregnancy outcomes: a systematic review and meta-analysis of case-control studies. Odontology 2012;100:232-40. https://doi.org/10.1007/s10266-011-0036-z
  11. Haerian-Ardakani A, Eslami Z, Rashidi-Meibodi F, Haerian A, Dallalnejad P, Shekari M, et al. Relationship between maternal periodontal disease and low birth weight babies. Iran J Reprod Med 2013;11:625-30.
  12. Moliterno LF, Monteiro B, Figueredo CM, Fischer RG. Association between periodontitis and low birth weight: a case-control study. J Clin Periodontol 2005;32:886-90. https://doi.org/10.1111/j.1600-051X.2005.00781.x
  13. Cruz SS, Costa Mda C, Gomes-Filho IS, Rezende EJ, Barreto ML, Dos Santos CA, et al. Contribution of periodontal disease in pregnant women as a risk factor for low birth weight. Community Dent Oral Epidemiol 2009;37:527-33. https://doi.org/10.1111/j.1600-0528.2009.00492.x
  14. Siqueira FM, Cota LO, Costa JE, Haddad JP, Lana AM, Costa FO. Intrauterine growth restriction, low birth weight, and preterm birth: adverse pregnancy outcomes and their association with maternal periodontitis. J Periodontol 2007;78:2266-76. https://doi.org/10.1902/jop.2007.070196
  15. Shirmohammadi A, Abdollahifard S, Chitsazi MT, Behlooli S. Relationship between maternal periodontal disease and Apgar score of newborns. J Periodontal Implant Sci 2012;42:212-6. https://doi.org/10.5051/jpis.2012.42.6.212
  16. Wang YL, Liou JD, Pan WL. Association between maternal periodontal disease and preterm delivery and low birth weight. Taiwan J Obstet Gynecol 2013;52:71-6. https://doi.org/10.1016/j.tjog.2013.01.011
  17. Ali TB, Abidin KZ. Relationship of periodontal disease to pre-term low birth weight infants in a selected population: a prospective study. Community Dent Health 2012;29:100-5.
  18. Vettore MV, Leal Md, Leao AT, da Silva AM, Lamarca GA, Sheiham A. The relationship between periodontitis and preterm low birthweight. J Dent Res 2008;87:73-8. https://doi.org/10.1177/154405910808700113
  19. Gomes-Filho IS, da Cruz SS, Rezende EJ, da Silveira BB, Trindade SC, Passos JS, et al. Periodontal status as predictor of prematurity and low birth weight. J Public Health Dent 2006;66:295-8. https://doi.org/10.1111/j.1752-7325.2006.tb04088.x
  20. Ide M, Papapanou PN. Epidemiology of association between maternal periodontal disease and adverse pregnancy outcomes--systematic review. J Clin Periodontol 2013;40 Suppl 14:S181-94. https://doi.org/10.1111/jcpe.12063
  21. United Nations Children's Fund; World Health Organization. Low birthweight: country, regional and global estimates [Internet]. New York; UNICEF; c2004 [cited 2011 Nov 22]. Available from: http://www.childinfo.org/files/low_birthweight_from_EY.pdf
  22. Government of Chhattisgarh. Human development report Chhattisgarh [Internet]. Raipur: Government of Chhattisgarh; c2005 [cited 2011 Nov 22] Available from: http://www.undp.org/content/dam/india/docs/human_develop_report_2005_chhattisgarh_full_report.pdf
  23. Corbet EF, Zee KY, Lo EC. Periodontal diseases in Asia and Oceania. Periodontol 2000 2002;29:122-52. https://doi.org/10.1034/j.1600-0757.2002.290107.x
  24. Ip M, Peyman E, Lohsoonthorn V, Williams MA. A case-control study of preterm delivery risk factors according to clinical subtypes and severity. J Obstet Gynaecol Res 2010;36:34-44. https://doi.org/10.1111/j.1447-0756.2009.01087.x
  25. Bassani DG, Olinto MT, Kreiger N. Periodontal disease and perinatal outcomes: a case-control study. J Clin Periodontol 2007;34:31-9. https://doi.org/10.1111/j.1600-051X.2006.01012.x
  26. Dasanayake AP, Boyd D, Madianos PN, Offenbacher S, Hills E. The association between Porphyromonas gingivalis-specific maternal serum IgG and low birth weight. J Periodontol 2001;72:1491-7. https://doi.org/10.1902/jop.2001.72.11.1491
  27. Lopez NJ, Da Silva I, Ipinza J, Gutierrez J. Periodontal therapy reduces the rate of preterm low birth weight in women with pregnancy-associated gingivitis. J Periodontol 2005;76(11 Suppl) :2144-53. https://doi.org/10.1902/jop.2005.76.11-S.2144
  28. Offenbacher S, Katz V, Fertik G, Collins J, Boyd D, Maynor G, et al. Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol 1996;67(10 Suppl):1103-13. https://doi.org/10.1902/jop.1996.67.10s.1103
  29. Dasanayake AP. Poor periodontal health of the pregnant woman as a risk factor for low birth weight. Ann Periodontol 1998;3:206-12. https://doi.org/10.1902/annals.1998.3.1.206
  30. Offenbacher S, Lieff S, Boggess KA, Murtha AP, Madianos PN, Champagne CM, et al. Maternal periodontitis and prematurity. Part I: Obstetric outcome of prematurity and growth restriction. Ann Periodontol 2001;6:164-74. https://doi.org/10.1902/annals.2001.6.1.164
  31. Bosnjak A, Relja T, Vucicevic-Boras V, Plasaj H, Plancak D. Pre-term delivery and periodontal disease: a case-control study from Croatia. J Clin Periodontol 2006;33:710-6. https://doi.org/10.1111/j.1600-051X.2006.00977.x
  32. Moore S, Ide M, Coward PY, Randhawa M, Borkowska E, Baylis R, et al. A prospective study to investigate the relationship between periodontal disease and adverse pregnancy outcome. Br Dent J 2004;197:251-8. https://doi.org/10.1038/sj.bdj.4811620
  33. Lunardelli AN, Peres MA. Is there an association between periodontal disease, prematurity and low birth weight? A population-based study. J Clin Periodontol 2005;32:938-46. https://doi.org/10.1111/j.1600-051X.2005.00759.x
  34. Noack B, Klingenberg J, Weigelt J, Hoffmann T. Periodontal status and preterm low birth weight: a case control study. J Periodontal Res 2005;40:339-45. https://doi.org/10.1111/j.1600-0765.2005.00808.x
  35. Mitchell-Lewis D, Engebretson SP, Chen J, Lamster IB, Papapanou PN. Periodontal infections and pre-term birth: early findings from a cohort of young minority women in New York. Eur J Oral Sci 2001;109:34-9. https://doi.org/10.1034/j.1600-0722.2001.00966.x
  36. Marakoglu I, Gursoy UK, Marakoglu K, Cakmak H, Ataoglu T. Periodontitis as a risk factor for preterm low birth weight. Yonsei Med J 2008;49:200-3. https://doi.org/10.3349/ymj.2008.49.2.200
  37. Nabet C, Lelong N, Colombier ML, Sixou M, Musset AM, Goffinet F, et al. Maternal periodontitis and the causes of preterm birth: the case-control Epipap study. J Clin Periodontol 2010;37:37-45. https://doi.org/10.1111/j.1600-051X.2009.01503.x
  38. Agueda A, Ramon JM, Manau C, Guerrero A, Echeverría JJ. Periodontal disease as a risk factor for adverse pregnancy outcomes: a prospective cohort study. J Clin Periodontol 2008;35:16-22.
  39. Kurdi AM, Mesleh RA, Al-Hakeem MM, Khashoggi TY, Khalifa HM. Multiple pregnancy and preterm labor. Saudi Med J 2004;25:632-7.
  40. Hasegawa K, Furuichi Y, Shimotsu A, Nakamura M, Yoshinaga M, Kamitomo M, et al. Associations between systemic status, periodontal status, serum cytokine levels, and delivery outcomes in pregnant women with a diagnosis of threatened premature labor. J Periodontol 2003;74:1764-70. https://doi.org/10.1902/jop.2003.74.12.1764

피인용 문헌

  1. Essential oils and isolated compounds from Lippia alba leaves and flowers: Antimicrobial activity and osteoclast apoptosis vol.35, pp.1, 2014, https://doi.org/10.3892/ijmm.2014.1995
  2. Increased infection with key periodontal pathogens during gestational diabetes mellitus vol.42, pp.6, 2015, https://doi.org/10.1111/jcpe.12418
  3. Role of Maternal Periodontitis in Preterm Birth vol.8, pp.None, 2014, https://doi.org/10.3389/fimmu.2017.00139
  4. The association between periodontal disease and adverse pregnancy outcomes in Northern Tanzania: a cross-sectional study vol.18, pp.3, 2018, https://doi.org/10.4314/ahs.v18i3.18
  5. Qualitative assessment of knowledge transfer regarding preterm birth in Malawi following the implementation of targeted health messages over 3 years vol.11, pp.None, 2014, https://doi.org/10.2147/ijwh.s185199
  6. Investigating the Relationship Between Decayed, Missing, and Filled Teeth Index and Preterm Labor in Pregnant Women in Hamedan, 2016 vol.11, pp.3, 2019, https://doi.org/10.34172/ajdr.2019.17
  7. Newborn Birth Weight and Associated Factors Among Mother-Neonate Pairs in Public Hospitals, North Wollo, Ethiopia vol.12, pp.None, 2014, https://doi.org/10.2147/phmt.s299202
  8. Periodontite materna e baixo peso ao nascer: revisão sistemática e metanálise vol.26, pp.suppl3, 2014, https://doi.org/10.1590/1413-812320212611.3.32362019