Pediatric Infection and Vaccine

The Korean Society of Pediatric Infectious Diseases (대한소아감염학회)
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Clinical Manifestations, Management, and Natural Course of Infants with Recurrent Bronchiolitis or Reactive Airways Disease

반복적인 모세기관지염, 과반응 기관지염을 보인 영유아의 임상양상, 치료와 자연경과

  • Park, Hyoun Jin (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Kim, Joo Hyun (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Chun, Yoon Hong (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Lee, Soo Young (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Kim, Sang Yong (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Kang, Jin Han (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
  • 박현진 (가톨릭대학교 의과대학 소아과학교실) ;
  • 김주현 (가톨릭대학교 의과대학 소아과학교실) ;
  • 전윤홍 (가톨릭대학교 의과대학 소아과학교실) ;
  • 이수영 (가톨릭대학교 의과대학 소아과학교실) ;
  • 김상용 (가톨릭대학교 의과대학 소아과학교실) ;
  • 강진한 (가톨릭대학교 의과대학 소아과학교실)
  • Received : 2013.09.22
  • Accepted : 2013.12.17
  • Published : 2014.04.25
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Abstract

Purpose: The purpose of this study was to investigate the clinical manifestations and 5-year natural course of recurrent bronchiolitis or reactive airways disease (RAD) in infants. Methods: We reviewed the medical records of infants with recurrent bronchiolitis from January 2007 to December 2007 at The Catholic University of Korea St. Mary's Hospital in Incheon, South Korea. Additionally, we telephoned their parents to confirm their present medical statuses. Results: Sixty-three subjects with recurrent bronchiolitis were identified. The mean age at admission was 8.1 months and the number of males was 44 (69.8%). Of the 63 infants with recurrent bronchiolitis, inhaled corticosteroids, bronchodilators, and antibiotics were given to 62 (98.4%), 53 (84.1%), and 40 (63.5%), respectively. Among the total 63 subjects, we were able to contact the parents of 45 children by telephone. None of these children had been hospitalized during the previous one year period due to respiratory infections or for other medical reasons. Of the 45 subjects we were able to contact, 38 (84.4%) had not experienced any further respiratory difficulties at all. Five (11.1%) had been diagnosed with allergic rhinitis while two (4.4%) were being managed for asthma. Conclusion: Most children who presented with recurrent episodes of bronchiolitis in infancy did not show any further respiratory difficulties after five years of age.

목적: 영유아기 두 번 이상 반복된 모세기관지염, 즉 과반응 기관지염(RAD)을 보인 환아의 임상양상, 치료와 5년 후 자연경과를 조사하고자 연구를 계획하였다. 방법: 2007년 1월부터 12월까지 연구병원 소아청소년과에 모세기관지염으로 2회 이상 입원한 영유아를 대상으로 하였다. 의무기록을 후향적으로 조사하였고, 추가로 5년 후 2013년 현재의 의학적 상태를 보호자와 전화면담을 시행하여 문의하였다. 결과: 2007년 1년간 총 63명의 영유아들이 2회 이상 모세기관지염으로 입원하였다. 연구대상의 평균연령은 8.1개월이었고, 이들 중 남아는 44명(69.8%)이었다. 입원 중 흡입 스테로이드 치료를 받은 환아는 62명(98.4%), 기관지확장제 치료 53명(84.1%) 항생제 치료 40명(63.5%)이었다. 대상 환아 63명 중 45명과 전화면담이 가능하였고, 이들 중, 2013년 현재 38명(84.4%)은 더 이상 호흡장애가 없었고, 5명(11.1%)은 알레르기 비염, 2명(4.4%)은 천식으로 치료 중이었다. 결론: 영유아기 반복적인 쌕쌕거림을 보였던 RAD 환아들의 대부분은, 호흡기가 성숙된 5년 후에는 더 이상 호흡장애를 보이지 않았다. 모세기관지염에 대한 국내 치료지침이 제안되어야 할 것이고 RAD의 자연경과에 대한 좀더 체계적인 연구가 필요하다.

Keywords

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