Journal of Gastric Cancer

The Korean Gastric Cancer Association (대한위암학회)
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Mixed Adenoneuroendocrine Gastric Carcinoma: A Case Report and Review of the Literature

  • Levi Sandri, Giovanni Battista (Department of Digestive Surgery, Regina Elena National Cancer Institute) ;
  • Carboni, Fabio (Department of Digestive Surgery, Regina Elena National Cancer Institute) ;
  • Valle, Mario (Department of Digestive Surgery, Regina Elena National Cancer Institute) ;
  • Visca, Paolo (Department of Pathology, Regina Elena National Cancer Institute) ;
  • Garofalo, Alfredo (Department of Digestive Surgery, Regina Elena National Cancer Institute)
  • Received : 2014.03.06
  • Accepted : 2014.03.21
  • Published : 2014.03.31
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Abstract

We present a rare case of a gastric mixed adenoneuroendocrine tumor and review the related English literature. A 77-year-old Caucasian woman was admitted to our department with nausea, anorexia, weight loss, and anemia. Esophagogastroduodenoscopy showed a large (>7 cm) ulcerative mass in the greater curvature of the stomach. Biopsy showed the presence of an adenocarcinoma with moderate differentiation. The patient underwent D2 subtotal gastrectomy. Histopathological analysis revealed a diagnosis of mixed gastric adenoneuroendocrine carcinoma. The post-operative course was uneventful, and at the 6-month follow-up, the patient was alive without evidence of recurrence. Our review of the English literature suggested that such cases are most often reported from eastern countries. Multimodal treatment should be the aim for these patients because of the neuroendocrine component of the tumor.

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References

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