Biomaterials and Biomechanics in Bioengineering

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Polyvinyl butyral DMN-conjugates for the controlled release of singlet oxygen in medical and antimicrobial applications

  • Posavec, Damir (Institute of Inorganic Chemistry, Johannes Kepler University Linz (JKU)) ;
  • Muller, Rainer (Institute of Physical and Theoretical Chemistry, University of Regensburg) ;
  • Bogner, Udo (Institute of Physical and Theoretical Chemistry, University of Regensburg) ;
  • Bernhardt, Gunther (Institute of Pharmacy, University of Regensburg) ;
  • Knor, Gunther (Institute of Inorganic Chemistry, Johannes Kepler University Linz (JKU))
  • Received : 2013.12.17
  • Accepted : 2014.06.17
  • Published : 2014.06.25
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Abstract

Covalent attachment of 1, 4-dimethylnaphthalene (DMN) based endoperoxide forming subunits to a polyvinyl butyral (PVB) backbone has been achieved. The functionalized polymer materials prepared and characterized here can serve as biocompatible carrier systems for studying cellular uptake, intermediate storage and delayed release of singlet oxygen, which opens up new doors for optimizing a variety of medical applications of photogenerated DMN-endoperoxides such as antiviral, antibacterial, antiplasmodial and antitumor activity.

Keywords

Acknowledgement

Grant : Sensory Photoreceptors in Natural and Artificial Systems

Supported by : DFG

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