Biomaterials and Biomechanics in Bioengineering

  • 제1권3호
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  • Pages.151-162
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  • 2014
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  • 2465-9835(pISSN)
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  • 2465-9959(eISSN)
테크노프레스 (Techno-Press)
권호 표지
DOI QR코드

DOI QR Code

Delivery of growth factor-associated genes to mesenchymal stem cells for cartilage and bone tissue regeneration

  • Ahn, Jongchan (Department of Biomedical Science, CHA University) ;
  • Park, Seah (Department of Biomedical Science, CHA University) ;
  • Cha, Byung-Hyun (Department of Biomedical Science, CHA University) ;
  • Kim, Jae Hwan (Department of Biomedical Science, CHA University) ;
  • Park, Hansoo (Department of Integrative Engineering, Chung-Ang University) ;
  • Joung, Yoon Ki (Department of Biomedical Science, CHA University) ;
  • Han, Inbo (Department of Neurosurgery, Bundang Medical Center, CHA University) ;
  • Lee, Soo-Hong (Department of Biomedical Science, CHA University)
  • 투고 : 2014.09.29
  • 심사 : 2014.09.30
  • 발행 : 2014.09.25
⟨ 이전 논문 다음 논문 ⟩

초록

Genetically-modified mesenchymal stem cells (GM-MSCs) have emerged as promising therapeutic tools for orthopedic degenerative diseases. GM-MSCs have been widely reported that they are able to increase bone and cartilage tissue regeneration not only by secreting transgene products such as growth factors in a long-term manner, also by inducing MSCs into tissue-specific cells. For example, MSCs modified with BMP-2 gene increased secretion of BMP-2 protein resulting in enhancement of bone regeneration, while MSCs with TGF-b gene did cartilage regeneration. In this review, we introduce several growth factors for gene delivery to MSCs and strategies for bone and cartilage tissue regeneration using GM-MSCs. Furthermore, we describe strategies for strengthening GM-MSCs to more intensively induce tissue regeneration by co-delivery system of multiple genes.

키워드

과제정보

연구 과제 주관 기관 : National Research Foundation of Korea (NRF)

참고문헌

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