The Korean journal of internal medicine

  • 제29권6호
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  • Pages.807-813
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  • 2014
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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DOI QR Code

Early effects of tumor necrosis factor inhibition on bone homeostasis after soluble tumor necrosis factor receptor use

  • Lim, Mie Jin (Division of Rheumatology, Department of Internal Medicine, Inha University Hospital) ;
  • Kwon, Seong Ryul (Division of Rheumatology, Department of Internal Medicine, Inha University Hospital) ;
  • Joo, Kowoon (Division of Rheumatology, Department of Internal Medicine, Inha University Hospital) ;
  • Son, Min Jung (Division of Rheumatology, Department of Internal Medicine, Inha University Hospital) ;
  • Park, Shin-Goo (Department of Occupational and Environmental Medicine, Inha University Hospital) ;
  • Park, Won (Division of Rheumatology, Department of Internal Medicine, Inha University Hospital)
  • 투고 : 2013.03.19
  • 심사 : 2014.10.02
  • 발행 : 2014.11.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: Our aim was to assess whether short-term treatment with soluble tumor necrosis factor (TNF) receptor affects circulating markers of bone metabolism in rheumatoid arthritis (RA) patients. Methods: Thirty-three active RA patients, treated with oral disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids for > 6 months, were administered etanercept for 12 weeks. Serum levels of bone metabolism markers were compared among patients treated with DMARDs at baseline and after etanercept treatment, normal controls and naive RA patients not previously treated with DMARDs (both age- and gender-matched). Results: Bone-specific alkaline phosphatase (BSALP) and serum c-telopeptide (CTX)-1 levels were lower in RA patients treated with DMARDs than in DMARD-naive RA patients. After 12 weeks of etanercept treatment, serum CTX-1 and sclerostin levels increased. In patients whose DAS28 improved, the sclerostin level increased from $1.67{\pm}2.12pg/mL$ at baseline to $2.51{\pm}3.03pg/mL$, which was statistically significant (p = 0.021). Increases in sclerostin levels after etanercept treatment were positively correlated with those of serum CTX-1 (r = 0.775), as were those of BSALP (r = 0.755). Conclusions: RA patients treated with DMARDs showed depressed bone metabolism compared to naive RA patients. Increases in serum CTX-1 and sclerostin levels after short-term etanercept treatment suggest reconstitution of bone metabolism homeostasis.

키워드

과제정보

연구 과제 주관 기관 : Inha University

참고문헌

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피인용 문헌

  1. Bone and TNF in rheumatoid arthritis: clinical implications vol.1, pp.1, 2014, https://doi.org/10.1136/rmdopen-2015-000065
  2. Short-Term Effects of TNF Inhibitors on Bone Turnover Markers and Bone Mineral Density in Rheumatoid Arthritis vol.98, pp.6, 2014, https://doi.org/10.1007/s00223-016-0114-x
  3. Effect of Tumor Necrosis Factor Inhibitor Therapy on Osteoclasts Precursors in Rheumatoid Arthritis vol.2017, pp.None, 2014, https://doi.org/10.1155/2017/2690402
  4. Effects of 1-year anti-TNF-α therapies on bone mineral density and bone biomarkers in rheumatoid arthritis and ankylosing spondylitis vol.39, pp.1, 2014, https://doi.org/10.1007/s10067-019-04771-3
  5. Effect of TNF inhibitors on bone mineral density in rheumatoid arthritis patients receiving bisphosphonate: a retrospective cohort study vol.40, pp.3, 2014, https://doi.org/10.1007/s00296-019-04418-1