Biomaterials and Biomechanics in Bioengineering

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Precise ultrasonic coating and controlled release of sirolimus with biodegradable polymers for drug-eluting stent

  • Joung, Yoon Ki (Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology) ;
  • Jang, Bu Nam (Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology) ;
  • Kang, Jong Hee (Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology) ;
  • Han, Dong Keun (Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology)
  • Received : 2014.01.01
  • Accepted : 2014.01.30
  • Published : 2014.03.25
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Abstract

In the current study, a drug-eluting stent coated with biodegradable polymers and sirolimus was developed by using an ultrasonic nanocoater and characterized in aspects of surface smoothness and coating thickness. In addition, in vitro release profiles of sirolimus by changing top coating layer with different biodegradable polymers were investigated. Smooth surfaces with variable thickness could be fabricated by optimizing polymer concentration, flow rate, nozzle-tip distance, gas pressure, various solvents and ultrasonic power. Smooth surface could be generated by using volatile solvents (acetone, chloroform, and methylene chloride) or post-treating with solvent vapor. Coating thickness could be controlled by varying injection volume or polymer concentration, and higher concentration could reduce the coating time while obtaining the same thickness. The thickness measurement was the most effectively performed by a conventional cutting method among three different methods that were investigated in this study. Release profiles of sirolimus were effectively controlled by changing polymers for top layer. PLGA made the release rate 3 times faster than PDLLA and PLLA and all top layers prevented burst release at the initial phase of profiles. Our results will provide useful and informative knowledge for developing drug-eluting stents, especially coated with biodegradable polymers.

Keywords

Acknowledgement

Grant : 줄기세포/후기내피전구세포 기반 관상동맥용 재내피화 미래세대 스텐트 개발

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