Mass Spectrometry Letters

  • 제5권1호
  • /
  • Pages.1-11
  • /
  • 2014
  • /
  • 2233-4203(pISSN)
  • /
  • 2093-8950(eISSN)
한국질량분석학회 (Korean Society for Mass Spectrometry)
권호 표지
DOI QR코드

DOI QR Code

Phospholipid Analysis by Nanoflow Liquid Chromatography-Tandem Mass Spectrometry

  • 투고 : 2014.02.05
  • 심사 : 2014.02.25
  • 발행 : 2014.03.24
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Lipids play important roles in biological systems; they store energy, play a structural role in the cell membrane, and are involved in cell growth, signal transduction, and apoptosis. Phospholipids (PLs) in particular have received attention in the medical and lipidomics research fields because of their involvement in human diseases such as diabetes, obesity, atherosclerosis, and many cancers associated with lipid metabolic disorders. Here I review experimental strategies for PL analysis based on nanoflow liquid chromatography-electrospray ionization-tandem mass spectrometry (nLC-ESI-MSn). In particular, discussed are lipid extraction methods, nanoflow LC separation of PLs, effect of ionization modifiers on the ESI of PLs, influence of chain lengths and unsaturation degree of acyl chains of PLs on MS intensity, structural determination of the molecular structure of PLs and their oxidized products, and quantitative profiling of PLs from biological samples such as tissue, urine, and plasma in relation to cancer and coronary artery disease.

키워드

참고문헌

  1. Miekle, P. J.; Christopher, M. J. Curr. Opin. Lipidol. 2011, 22, 210. https://doi.org/10.1097/MOL.0b013e3283453dbe
  2. Brouwers, J. F. H. M.; Vernooji, E. A. A. M.; Tielens, A. G. M.; van Golde, L. M. G. J. Lipid Res. 1999, 40, 164.
  3. Wright, M. M.; Howe, A. G.; Zaremberg, V. Biochem. Cell Biol. 2004, 82, 18.
  4. Houjou, T.; Yamatani, K.; Imagawa, M.; Shimizu, T.; Taguchi, R. Rapid Commun. Mass Spectrom. 2005, 19, 654. https://doi.org/10.1002/rcm.1836
  5. Bougnoux, P.; Chajes, V.; Lanson, M.; Hacene, K.; Body, G.; Couet, C.; Folch, O. L. Breast Cancer Res. Treat. 1992, 20, 185.
  6. Leach, M. O.; Verrill, M.; Glaholm, J.; Smith, T. A. D.; Collins, D. J.; Payne, G. S.; Sharp, J. C.; Ronen, S. M.; McCready, V. R.; Powles, T. J.; Smith, I. E. NMR Biomed. 1998, 11, 314. https://doi.org/10.1002/(SICI)1099-1492(1998110)11:7<314::AID-NBM522>3.0.CO;2-Z
  7. Wolf, C.; Quinn, P. J. Prog. Lipid Res. 2008, 47, 15. https://doi.org/10.1016/j.plipres.2007.09.001
  8. Kim, H.; Min, H. K.; Kong, G.; Moon, M. H. Anal. Bioanal. Chem. 2009, 393, 1649. https://doi.org/10.1007/s00216-009-2621-3
  9. Xu, Y.; Shen, Z.; Wiper, D. W.; Wu, M.; Morton, R. E.; Elson, P.; Kennedy, A. W.; Belinson, J.; Markman, M.; Casey, G. JAMA. 1998, 280, 719. https://doi.org/10.1001/jama.280.8.719
  10. Sutphen, R.; Xu, Y.; Wilbanks, G. D.; Fiorica, J.; Grendys Jr., E. C.; LaPolla, J. P.; Arango, H.; Hoffman, M. S.; Martino, M.; Wakeley, K.; Griffin, D.; Blanco, R. W.; Cantor, A. B.; Xiao, Y. J.; Krischer, J. P. Cancer Epidemiol. Biomarkers Prev. 2004, 13, 1185.
  11. Zhao, Z.; Xiao, Y.; Elson, P.; Tan, H.; Plummer, S. J.; Berk, M.; Aung, P. P.; Lavery, I. C.; Achkar, J. P.; Li, L.; Casey, G.; Xu, Y. J. Clin. Oncol. 2007, 25, 2696. https://doi.org/10.1200/JCO.2006.08.5571
  12. Swanson, M. G.; Vigneron, D. B.; Tabatabai, Z. L.; Males, R. G.; Schmitt, L.; Carroll, P. R.; James, J. K.; Hurd, R. E.; Kurhanewicz, J. Magn. Reson. Med. 2003, 50, 944. https://doi.org/10.1002/mrm.10614
  13. Jeong, R. U.; Lim, S.; Kim, M. O.; Moon, M. H. Anal. Bioanal. Chem. 2011, 401, 689. https://doi.org/10.1007/s00216-011-5113-1
  14. Byeon, S. K.; Lee, J. Y.; Lim, S.; Choi, D.; Moon, M. H. J. Chromatogr. A 2012, 1270, 246. https://doi.org/10.1016/j.chroma.2012.11.012
  15. Helmy, F. M.; Nosavanh, L.; Haynes, H.; Juracka, A. Cell Biochem. Funct. 2008, 26, 434. https://doi.org/10.1002/cbf.1460
  16. Murray, K. E.; Fried, B.; Sherma, J. Acta Chromatogr. 2007, 18, 190.
  17. Fuchs, B.; Schiller, J.; Suss, R.; Schurenberg, M.; Suckau, D. Anal. Bioanal. Chem. 2007, 389, 827. https://doi.org/10.1007/s00216-007-1488-4
  18. Rohlfing, A.; Muthing, J.; Pojlentz, G.; Distler, I.; Peter-Katalinc, J.; Berkenkamp, S.; Dreisewerd, K. Anal. Chem. 2007, 79, 5793. https://doi.org/10.1021/ac070633x
  19. Taguchi, R.; Hayakawa, J.; Takeuchi, Y.; Ishida, M. J. Mass Spectom. 2000, 35, 953. https://doi.org/10.1002/1096-9888(200008)35:8<953::AID-JMS23>3.0.CO;2-4
  20. Isaac, G.; Bylund, D.; Mansson, J. -E.; Markides, K. E.; Borgquist, J. J. Neurosci. Methods 2003, 128, 111. https://doi.org/10.1016/S0165-0270(03)00168-7
  21. Hermansson, M.; Uphoff, A.; Kakela, R.; Somerharju, P. Anal. Chem. 2005, 77, 2166. https://doi.org/10.1021/ac048489s
  22. Oursel, D.; Loutelier-Bourhis, C.; Orange, D.; Chevalier, S.; Norris, V.; Lange, C. M. Rapid Commun. Mass Spectrom. 2007, 21, 1721. https://doi.org/10.1002/rcm.3013
  23. Pacetti, D.; Borselli, E.; Lucci, P.; Frega, N. G. J. Chromatogr. A 2007, 1150, 242.
  24. Bang, D. Y.; Kang, D.; Moon, M. H. J. Chromatogr. A 2006, 1104, 222. https://doi.org/10.1016/j.chroma.2005.12.005
  25. Bang, D. Y.; Ahn, E. J.; Moon, M. H. J. Chromatogr. B 2007, 852, 268. https://doi.org/10.1016/j.jchromb.2007.01.028
  26. Ahn, E. J.; Kim, H.; Chung, B. C.; Moon, M. H. J. Sep. Sci. 2007, 30, 2598. https://doi.org/10.1002/jssc.200700231
  27. Byeon, S. K.; Lee, J. Y.; Moon, M. H. Analyst 2012, 137, 451. https://doi.org/10.1039/c1an15920h
  28. Folch, J.; Lees, M.; Sloan Stanley, G. H. J. Biol. Chem. 1957, 226, 497.
  29. Bligh, E. G.; Dyer, W. J. Can. J. Biochem. Physiol. 1959, 37, 911. https://doi.org/10.1139/o59-099
  30. Lim, S.; Byeon, S. K.; Lee, J. Y.; Moon, M. H. J. Mass Spectrom. 2012, 47, 1004. https://doi.org/10.1002/jms.3033
  31. Lee, J. Y.; Min, H. K., Moon, M. H. Anal Bioanal. Chem. 2011, 400, 2953. https://doi.org/10.1007/s00216-011-4958-7
  32. Bang, D. Y.; Lim, S. Moon, M. H. J. Chromatogr. A 2012, 1240, 69. https://doi.org/10.1016/j.chroma.2012.03.073
  33. Fang, J.; Barcelona, M. J. J. Microbiol. Methods 1998, 33, 23. https://doi.org/10.1016/S0167-7012(98)00037-2
  34. Taguchi, R.; Houjou, T,; Nakanishi. H.; Yamazaki, T.; Ishida, M.; Imagawa, M.; Shimizu, T. J. Chromatogr. B 2005, 823, 26. https://doi.org/10.1016/j.jchromb.2005.06.005
  35. Koivusalo, M.; Haimi, P.; Heikinheimo, L,; Kostiainen, R.; Somerharaju, P. J. Lipid Res. 2001, 42, 663.
  36. Ahn, E. J.; Kim, H.; Chung, B. C.; Kong, G.; Moon, M. H. J. Chromatogr. A 2008, 1194, 96. https://doi.org/10.1016/j.chroma.2008.04.031
  37. Min, H. K.; Kong, G.; Moon, M. H. Anal. Bioanal. Chem. 2010, 396, 1273. https://doi.org/10.1007/s00216-009-3292-9
  38. Kim, H.; Ahn, E. J.; Moon, M. H. Analyst 2008, 133, 1656. https://doi.org/10.1039/b804715d
  39. Olayioye, M.; Vehring, S.; Muller, P.; Herrmann, A.; Schiller, J.; Thiele, C.; Linderman, G. J.; Visvader, J. E.; Pomorski, T. J. Biol. Chem. 2005, 280, 27476.
  40. Lee, J. Y.; Min, H. K.; Choi, D.; Moon, M. H. J. Chromatogr. A 2010, 1217, 1660. https://doi.org/10.1016/j.chroma.2010.01.006
  41. Rajman, I.; Kendall, M. J.; Cramb, R.; Holder, R. L.; Salih, M.; Gammage, M. D. Atherosclerosis 1996, 125, 231. https://doi.org/10.1016/0021-9150(96)05881-9
  42. Adler, L.; Hill, J. S.; Frohlich, J. Clin. Biochem. 2000, 33, 187. https://doi.org/10.1016/S0009-9120(00)00061-8
  43. Lee, J. Y.; Lim, S.; Park, S.; Moon, M. H. J. Chromatogr. A 2013, 1288, 54. https://doi.org/10.1016/j.chroma.2013.02.086
  44. Ehara, S.; Ueda, M.; Naruko, T.; Haze, K.; Itoh, A.; Otsuka, M.; Komatsu, R.; Matsuo, T.; Itabe, H.; Takano, T.; Tsukamoto, Y.; Yoshiyama, Y.; Takeuchi, K.; Yoshikawa, J.; Becker, A. E. Circulation 2001, 103, 1955. https://doi.org/10.1161/01.CIR.103.15.1955
  45. Adachi, J.; Asano, M.; Yoshioka, N.; Nushida, H.; Ueno, Y. Kobe J. Med. Sci. 2006, 52, 127.
  46. Nie, H.; Liu, R.; Yang, Y.; Bai, Y.; Guan, Y.; Qian, D.; Wang, T.; Liu, H. J. Lipid Res. 2010, 51, 2833. https://doi.org/10.1194/jlr.D007567
  47. Bang, D. Y.; Moon, M. H. J. Chromatogr. A 2013, 1310, 82. https://doi.org/10.1016/j.chroma.2013.08.069

피인용 문헌

  1. High-throughput and rapid quantification of lipids by nanoflow UPLC-ESI-MS/MS: application to the hepatic lipids of rabbits with nonalcoholic fatty liver disease vol.408, pp.18, 2016, https://doi.org/10.1007/s00216-016-9592-y
  2. Lipidomic Perturbations in Lung, Kidney, and Liver Tissues of p53 Knockout Mice Analyzed by Nanoflow UPLC-ESI-MS/MS vol.15, pp.10, 2016, https://doi.org/10.1021/acs.jproteome.6b00566
  3. Profiling of complex lipids in marine microalgae by UHPLC/tandem mass spectrometry vol.17, 2016, https://doi.org/10.1016/j.algal.2016.05.016
  4. Optimizing the lipidomics workflow for clinical studies—practical considerations vol.407, pp.17, 2015, https://doi.org/10.1007/s00216-015-8633-2
  5. Variations in plasma and urinary lipids in response to enzyme replacement therapy for Fabry disease patients by nanoflow UPLC-ESI-MS/MS vol.408, pp.9, 2016, https://doi.org/10.1007/s00216-016-9318-1
  6. Profiling of Oxidized Phospholipids in Lipoproteins from Patients with Coronary Artery Disease by Hollow Fiber Flow Field-Flow Fractionation and Nanoflow Liquid Chromatography–Tandem Mass Spectrometry vol.87, pp.2, 2015, https://doi.org/10.1021/ac503973p
  7. Complexation of phosphates by 1,3-bis(3-(2-pyridylureido)propyl)-1,1,3,3-tetramethyldisiloxane vol.29, pp.23, 2015, https://doi.org/10.1002/rcm.7386