The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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A Case of Thrombotic Thrombocytopenic Purpura associated with Clopidogrel in a Patient with Acute Cerebral Infarction

Clopidogrel 투여 후 발생한 혈전성 혈소판감소성 자반증 1예

  • Park, JinHee (Departments of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Lee, YeongBok (Departments of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Park, HaNeul (Departments of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Min, JiWon (Departments of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Ko, YuMi (Departments of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Kim, Young-Ok (Departments of Internal Medicine, The Catholic University of Korea, College of Medicine)
  • 박진희 (가톨릭대학교 의과대학 내과학교실) ;
  • 이영복 (가톨릭대학교 의과대학 내과학교실) ;
  • 박하늘 (가톨릭대학교 의과대학 내과학교실) ;
  • 민지원 (가톨릭대학교 의과대학 내과학교실) ;
  • 고유미 (가톨릭대학교 의과대학 내과학교실) ;
  • 김영옥 (가톨릭대학교 의과대학 내과학교실)
  • Received : 2013.07.11
  • Accepted : 2013.12.05
  • Published : 2014.11.01
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Abstract

Clopidogrel is an antiplatelet agent prescribed widely to prevent stent thrombosis after coronary or peripheral vascular interventions and for stroke prophylaxis. The side effects of this drug include gastrointestinal symptoms, such as nausea, abdominal pain, vomiting, and bleeding. Thrombotic thrombocytopenia purpura (TTP) is a rare complication of this drug. Here, we report a case of clopidogrel-associated TTP in a patient with cerebral infarction. To our knowledge, it is first reported case of clopidogrel-associated TTP in Korea.

본 증례는 급성 뇌경색 환자에서 clopidgrel 복용 후 발생한 혈전성 혈소판 감소성 자반증의 예이다. 환자는 급성 뇌경색으로 타 병원에서 입원치료 중 10병일째부터 발생한 발열 및 혈소판감소를 주소로 내원하여 혈전성 혈소판 감소성 자반증으로 진단받고 혈장 교환술 치료를 시행받았다. Clopidogrel 복용 후 발생하는 TTP는 발생빈도는 낮으나 조기에 발견하여 치료하지 않으면 진행과정이 급속도로 진행하여 사망에 이르는 매우 치명적인 질환으로 발생가능성을 반드시 인지하고 있어야 할 것으로 생각된다.

Keywords

References

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