Journal of Korean Academy of Nursing (대한간호학회지)

Korean Society of Nursing Science (한국간호과학회)
권호 표지
DOI QR코드

DOI QR Code

Late Effects, Social Adjustment, and Quality of Life in Adolescent Survivors of Childhood Leukemia

백혈병 생존 청소년의 신체적.정서적 후유장애, 사회적응 및 삶의 질

  • Hong, Sung Sil (Graduate School, The Catholic University of Korea) ;
  • Park, Ho Ran (College of Nursing, The Catholic University of Korea) ;
  • Kim, Kwang Sung (BMT Center, Seoul St. Mary's Hospital, The Catholic University of Korea) ;
  • Choi, Sun Hee (BMT Center, Seoul St. Mary's Hospital, The Catholic University of Korea)
  • 홍성실 (가톨릭대학교 대학원) ;
  • 박호란 (가톨릭대학교 간호대학) ;
  • 김광성 (가톨릭대학교 서울성모병원 BMT 센터) ;
  • 최선희 (가톨릭대학교 서울성모병원 BMT 센터)
  • Received : 2013.10.15
  • Accepted : 2014.01.02
  • Published : 2014.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose: This study was conducted to examine the late effects, social adjustment, and quality of life in adolescents who had been completely treated for childhood leukemia and their parents. Methods: Participants consisted of 41 pairs of adolescent survivors (13-18 years) and their parents. Parents checked for their child's physical late effects. The Korean Version of Post-Traumatic Symptoms for psychological late effects, social functioning questionnaire for social adjustment and the PedsQL 4.0 Generic Core Scales for quality of life were completed by adolescents and parents. Data were analyzed using SPSS. Results: Twenty out of 41 adolescents had one or more physical late effects. Adolescents showed more serious psychological late effect than parents. Five children and seven parents had above cut-off scores and they were considered the high risk group for posttraumatic symptoms. Parent-reported scores were significantly higher than child-reported scores in terms of social adjustment and emotional functioning of quality of life. Low school functioning in adolescents was associated with physical late effects. Conclusion: The results indicate that long-term and systematic management for childhood leukemia survivors affect positive social adjustment and can further improve quality of life.

Keywords

References

  1. Ministry of Health & Welfare, Korea Central Cancer Registry, National Cancer Center. Annual report of cancer statistics in Korea in 2010. Seoul: Ministry of Health & Welfare; 2012.
  2. Hunger SP, Lu X, Devidas M, Camitta BM, Gaynon PS, Winick NJ, et al. Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: A report from the children's oncology group. Journal of Clinical Oncology. 2012;30(14):1663-1669. http://dx.doi.org/10.1200/jco.2011.37.8018
  3. Haddy TB, Mosher RB, Reaman GH. Late effects in long-term survivors after treatment for childhood acute leukemia. Clinical Pediatrics. 2009;48(6):601-608. http://dx.doi.org/10.1177/0009922809332680
  4. Lof CM, Winiarski J, Giesecke A, Ljungman P, Forinder U. Health-related quality of life in adult survivors after paediatric allo-SCT. Bone Marrow Transplantation. 2009;43(6):461-468. http://dx.doi.org/10.1038/bmt.2008.338
  5. Clarke SA, Skinner R, Guest J, Darbyshire P, Cooper J, Vora A, et al. Clinical outcomes and health-related quality of life (HRQOL) following haemopoietic stem cell transplantation (HSCT) for paediatric leukaemia. Child: Care, Health and Development. 2011;37(4):571-580. http://dx.doi.org/10.1111/j.1365-2214.2010.01182.x
  6. Edelstein K, D'Agostino N, Bernstein LJ, Nathan PC, Greenberg ML, Hodgson DC, et al. Long-term neurocognitive outcomes in young adult survivors of childhood acute lymphoblastic leukemia. Journal of Pediatric Hematology Oncology. 2011;33(6):450-458. http://dx.doi.org/10.1097/MPH.0b013e31820d86f2
  7. Gurney JG, Krull KR, Kadan-Lottick N, Nicholson HS, Nathan PC, Zebrack B, et al. Social outcomes in the childhood cancer survivor study cohort. Journal of Clinical Oncology. 2009;27(14):2390-2395. http://dx.doi.org/10.1200/jco.2008.21.1458
  8. You MA. Content analysis on psychosocial adjustment of adolescent survivors of leukemia. Journal of Korean Academy of Child Health Nursing. 2006;12(3):304-313.
  9. Kim YJ, Cha HG, Kim CA, Park YJ, Kim HJ, Seo JJ, et al. Child cancer survivors' quality of life based on their parents' support and past history. Journal of Korean Academy of Psychiatric and Mental Health Nursing. 2008;17(1):85-96.
  10. Kim MA, Yi J. Psychological distress in adolescent and young adult survivors of childhood cancer in Korea. Journal of Pediatric Oncology Nursing. 2013;30(2):99-108. http://dx.doi.org/10.1177/1043454213478469
  11. Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods. 2007;39(2):175-191. https://doi.org/10.3758/BF03193146
  12. Korea Centers for Disease Control and Prevention, The Korean Pediatric Society, The Committee for the Development of Growth Standard for Korean Children and Adolescents. 2007 Korean national growth charts: Review of developmental process and outlook [Internet]. Seoul: Korea Centers for Disease Control and Prevention; 2007 November [cited 2013 August 1]. Available from: http://www.cdc.go.kr/CDC/cms/content/03/12103_view.html.
  13. Greenwald R, Rubin A. Assessment of posttraumatic symptoms in children: Development and preliminary validation of parent and child scales. Research on Social Work Practice. 1999;9(1):61-75. http://dx.doi.org/10.1177/104973159900900105
  14. Lee KM, Jeong SH, Lee WK, Chung US. Reliability and validity of the Korean version of the child report of post-traumatic symptoms (CROPS) and the parent report of post-traumatic symptoms (PROPS). Journal of the Korean Academy of Child and Adolescent Psychiatry. 2011;22(3):169-181. https://doi.org/10.5765/jkacap.2011.22.3.169
  15. Meeske KA, Ruccione K, Globe DR, Stuber ML. Posttraumatic stress, quality of life, and psychological distress in young adult survivors of childhood cancer. Oncology Nursing Forum. 2001;28(3):481-489.
  16. Kamibeppu K, Sato I, Honda M, Ozono S, Sakamoto N, Iwai T, et al. Mental health among young adult survivors of childhood cancer and their siblings including posttraumatic growth. Journal of Cancer Survivorship. 2010;4(4):303-312. http://dx.doi.org/10.1007/s11764-010-0124-z
  17. Varni JW, Seid M, Kurtin PS. PedsQL 4.0: Reliability and validity of the pediatric quality of life inventory version 4.0 generic core scales in healthy and patient populations. Medical Care. 2001;39(8):800-812. https://doi.org/10.1097/00005650-200108000-00006
  18. Kook SH, Varni JW. Validation of the Korean version of the pediatric quality of life inventory 4.0 (PedsQL) generic core scales in school children and adolescents using the Rasch model. Health and Quality of Life Outcomes. 2008;6:41. http://dx.doi.org/10.1186/1477-7525-6-41
  19. Bertorello N, Manicone R, Galletto C, Barisone E, Fagioli F. Physical activity and late effects in childhood acute lymphoblastic leukemia longterm survivors. Pediatric Hematology and Oncology. 2011;28(5):354-363. http://dx.doi.org/10.3109/08880018.2010.550987
  20. Pemberger S, Jagsch R, Frey E, Felder-Puig R, Gadner H, Kryspin-Exner I, et al. Quality of life in long-term childhood cancer survivors and the relation of late effects and subjective well-being. Supportive Care in Cancer. 2005;13(1):49-56. http://dx.doi.org/10.1007/s00520-004-0724-0
  21. Michel G, Bordigoni P, Simeoni MC, Curtillet C, Hoxha S, Robitail S, et al. Health status and quality of life in long-term survivors of childhood leukaemia: The impact of haematopoietic stem cell transplantation. Bone Marrow Transplantation. 2007;40(9):897-904. http://dx.doi.org/10.1038/sj.bmt.1705821
  22. Asner S, Ammann RA, Ozsahin H, Beck-Popovic M, von der Weid NX. Obesity in long-term survivors of childhood acute lymphoblastic leukemia. Pediatric Blood & Cancer. 2008;51(1):118-122. http://dx.doi.org/10.1002/pbc.21496
  23. Love E, Schneiderman JE, Stephens D, Lee S, Barron M, Tsangaris E, et al. A cross-sectional study of overweight in pediatric survivors of acute lymphoblastic leukemia (ALL). Pediatric Blood & Cancer. 2011;57(7): 1204-1209. http://dx.doi.org/10.1002/pbc.23010
  24. Oeffinger KC, Mertens AC, Sklar CA, Yasui Y, Fears T, Stovall M, et al. Obesity in adult survivors of childhood acute lymphoblastic leukemia: A report from the childhood cancer survivor study. Journal of Clinical Oncology. 2003;21(7):1359-1365. https://doi.org/10.1200/JCO.2003.06.131
  25. Garmey EG, Liu Q, Sklar CA, Meacham LR, Mertens AC, Stovall MA, et al. Longitudinal changes in obesity and body mass index among adult survivors of childhood acute lymphoblastic leukemia: A report from the childhood cancer survivor study. Journal of Clinical Oncology. 2008;26(28):4639-4645. http://dx.doi.org/10.1200/jco.2008.16.3527
  26. Wenninger K, Helmes A, Bengel J, Lauten M, Völkel S, Niemeyer CM. Coping in long-term survivors of childhood cancer: Relations to psychological distress. Psycho-Oncology. 2013;22(4):854-861. http://dx.doi.org/10.1002/pon.3073
  27. Nuss SL, Wilson ME. Health-related quality of life following hematopoietic stem cell transplant during childhood. Journal of Pediatric Oncology Nursing. 2007;24(2):106-115. http://dx.doi.org/10.1177/1043454206296033
  28. Harila MJ, Salo J, Lanning M, Vilkkumaa I, Harila-Saari AH. High health-related quality of life among long-term survivors of childhood acute lymphoblastic leukemia. Pediatric Blood & Cancer. 2010;55 (2):331-336. http://dx.doi.org/10.1002/pbc.22531

Cited by

  1. Health-related Needs and Quality of Life in Childhood Cancer Survivors vol.15, pp.4, 2015, https://doi.org/10.5388/aon.2015.15.4.246
  2. The Effect of Perceived Social Stigma on Self-Esteem of Childhood Cancer Survivors vol.36, pp.1, 2014, https://doi.org/10.15709/hswr.2016.36.1.497
  3. The Experiences of Korean Young Adult Survivors of Childhood Cancer : A Photovoice Study vol.26, pp.8, 2014, https://doi.org/10.1177/1049732315599374
  4. Qualitative Evaluation of Effectiveness of ‘Family Hope Partner Project’ for Pediatric Cancer Patients and their Families vol.55, pp.None, 2017, https://doi.org/10.16975/kjfsw.2017..55.003