생체재료학회지 (Biomaterials Research)

  • 제18권4호
  • /
  • Pages.121-125
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  • 2014
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  • 1226-4601(pISSN)
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  • 2055-7124(eISSN)
한국생체재료학회 (Korean Society for Biomaterials)
권호 표지
DOI QR코드

DOI QR Code

Polyurethane membrane with porous surface for controlled drug release in drug eluting stent

  • Seo, Eun Ha (Department of Biotechnology, The Catholic University of Korea) ;
  • Na, Kun (Department of Biotechnology, The Catholic University of Korea)
  • 투고 : 2014.07.30
  • 심사 : 2014.09.24
  • 발행 : 2014.12.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background: Membrane covered drug eluting stents (DES) were prepared to prevent tumor ingrowth and to control drug release. Polyurethane (PU) is commonly used for DES coating material because of high tensile strength. The release of paclitaxel (PTX) may increase from porous PU membrane. Results: Polyethylene glycol (PEG) was incorporated into PU membranes to form porous structure and control the release of hydrophobic anti-cancer drug such as PTX. The bare metal stents were coated with PEG incorporated PU and then, PEG was washed out to form porous structure. The crystallization of PTX was inhibited in porous PU membranes and the release of PTX from porous PU membranes was approximately 8.6% more extended over 19 days. Conclusions: The enhanced release of PTX from porous PU membranes may increase the patency for the DES covering materials.

키워드

과제정보

연구 과제번호 : Development of nonvascular drug eluting stent for treatment of gastrointestinal disease

연구 과제 주관 기관 : Ministry of Trade, industry & Energy (MOTIE, Korea)

참고문헌

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피인용 문헌

  1. Sustained Release Drug Delivery Applications of Polyurethanes vol.10, pp.2, 2014, https://doi.org/10.3390/pharmaceutics10020055
  2. Extended Nitric Oxide-Releasing Polyurethanes via S-Nitrosothiol-Modified Mesoporous Silica Nanoparticles vol.11, pp.13, 2019, https://doi.org/10.1021/acsami.8b19236
  3. Porous polyurethane film fabricated via the breath figure approach for sustained drug release vol.136, pp.25, 2019, https://doi.org/10.1002/app.47658
  4. Influence of Polymer Composition on the Controlled Release of Docetaxel: A Comparison of Non-Degradable Polymer Films for Oesophageal Drug-Eluting Stents vol.12, pp.5, 2014, https://doi.org/10.3390/pharmaceutics12050444
  5. Three-dimensional printed 5-fluorouracil eluting polyurethane stents for the treatment of oesophageal cancers vol.8, pp.23, 2014, https://doi.org/10.1039/d0bm01355b
  6. Intelligent H2S release coating for regulating vascular remodeling vol.6, pp.4, 2014, https://doi.org/10.1016/j.bioactmat.2020.09.023