Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
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New approach for the treatment of osteoradionecrosis with pentoxifylline and tocopherol

  • Fan, Huan (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Kim, Soung Min (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Cho, Yun Ju (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Eo, Mi Young (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Lee, Suk Keun (Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University) ;
  • Woo, Kyung Mi (Department of Dental Pharmacology & Therapeutics, Dental Research Institute, School of Dentistry, Seoul National University)
  • Received : 2014.08.13
  • Accepted : 2014.09.12
  • Published : 2014.12.01
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Abstract

Osteoradionecrosis (ORN) of the jaw is a significant complication of radiotherapy for oral cavity cancer. In addition to antibiotic medication, treatment options such as hyperbaric oxygen therapy, surgical approaches, and combined therapy with pentoxifylline and tocopherol have been recently introduced. In this review article, we will discuss the definition and classifications of osteoradionecrosis, its etiology and pathophysiology, previous treatment options, oral and maxillofacial complications of radiotherapy, basic information on pentoxifylline and tocopherol, recent reports of pentoxifylline and tocopherol combined therapy, and, finally, ORN-induced animal models and future approaches.

Keywords

Acknowledgement

Supported by : Ministry of Health & Welfare

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