Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
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Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing

  • Cai, Elijah Zhengyang (Department of Surgery, National University Health System) ;
  • Teo, Erin Yiling (Department of Reproductive Medicine, KK Women's and Children Hospital) ;
  • Jing, Lim (Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University) ;
  • Koh, Yun Pei (Department of Surgery, National University Health System) ;
  • Qian, Tan Si (Centre for Biomedical Materials Applications and Technology (BIOMAT), Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore) ;
  • Wen, Feng (Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University) ;
  • Lee, James Wai Kit (Department of Surgery, National University Health System) ;
  • Hing, Eileen Chor Hoong (Department of Surgery, National University of Singapore) ;
  • Yap, Yan Lin (Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, National University Health System) ;
  • Lee, Hanjing (Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, National University Health System) ;
  • Lee, Chuen Neng (Department of Surgery, National University of Singapore) ;
  • Teoh, Swee-Hin (Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University) ;
  • Lim, Jane (Department of Surgery, National University of Singapore) ;
  • Lim, Thiam Chye (Department of Surgery, National University of Singapore)
  • Received : 2014.06.29
  • Accepted : 2014.08.03
  • Published : 2014.11.15
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Abstract

Background The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing. Methods 16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two $3.0{\times}3.0cm$ full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration. Results Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): $8.33cm^2$, $4.90cm^2$, $3.12cm^2$, $1.84cm^2$; Mepitel (n=6): $10.29cm^2$, $5.53cm^2$, $3.63cm^2$, $2.02cm^2$; at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups. Conclusions BPM is comparable to Mepitel as a safe and efficacious wound dressing.

Keywords

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