Biomolecules & Therapeutics

  • 제22권1호
  • /
  • Pages.35-40
  • /
  • 2014
  • /
  • 1976-9148(pISSN)
  • /
  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
권호 표지
DOI QR코드

DOI QR Code

Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin

  • 투고 : 2013.10.08
  • 심사 : 2013.12.31
  • 발행 : 2014.01.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Resveratrol is a polyphenolic compound found in various natural products such as grapes and berries and possesses anti-cancer, anti-hyperlipidemia, and anti-aging properties. Recently, it has been reported that resveratrol inhibits ${\alpha}$-melanocyte-stimulating hormone signaling, viability, and migration in melanoma cells. However, these effects have not been confirmed in vivo, specifically brownish guinea pigs. To evaluate the potential of resveratrol as a regulator of melanin for hyperpigmentation therapy, the influence of resveratrol on pigmentation was investigated by ultraviolet B-induced hyperpigmentation in brownish guinea pig skin. We found that resveratrol reduced the expression of melanogenesis-related proteins tyrosinase, tyrosinase-related proteins 1 and 2, and microphthalmia-associated transcription factor in melanoma cells. Furthermore, topical application of resveratrol was demonstrated to significantly decrease hyperpigmentation on ultraviolet B-stimulated guinea pig skin in vivo. Based on our histological data, resveratrol inhibits melanin synthesis via a reduction in tyrosinase-related protein 2 among the melanogenic enzymes. This study is the first to provide evidence supporting resveratrol as a depigmentation agent, along with further clinical investigation of resveratrol in ultraviolet B-induced skin disorders such as hyperpigmentation and skin photoaging.

키워드

참고문헌

  1. Baur, J. A. and Sinclair, D. A. (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 5, 493-506. https://doi.org/10.1038/nrd2060
  2. Bertolotto, C., Busca, R., Abbe, P., Bille, K., Aberdam, E., Ortonne, J. P. and Ballotti, R. (1998) Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia. Mol. Cell. Biol. 18, 694-702. https://doi.org/10.1128/MCB.18.2.694
  3. Chen, Y. J., Chen, Y. Y., Lin, Y. F., Hu, H. Y. and Liao, H. F. (2013) Resveratrol inhibits alpha-melanocyte-stimulating hormone signaling, viability, and invasiveness in melanoma cells. Evid. Based Complement. Alternat. Med. 2013, 632121.
  4. Del Follo-Martinez A., Banerjee, N., Li, X., Safe, S. and Mertens-Talcott, S. (2013) Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a. Nutr. Cancer 65, 494-504. https://doi.org/10.1080/01635581.2012.725194
  5. Franco, D. C., de Carvalho, G. S., Rocha, P. R., da Silva, Teixeira R., da Silva, A. D and Raposo, N. R. (2012) Inhibitory effects of resveratrol analogs on mushroom tyrosinase activity. Molecules 17, 11816-11825. https://doi.org/10.3390/molecules171011816
  6. Gatson, J. W., Liu, M. M., Abdelfattah, K., Wigginton, J. G., Smith, S., Wolf, S. and Minei, J. P. (2013) Resveratrol decreases inflammation in the brain of mice with mild traumatic brain injury. J. Trauma Acute Care Surg. 74, 470-474. https://doi.org/10.1097/TA.0b013e31827e1f51
  7. Gillbro, J. M. and Olsson, M. J. (2011) The melanogenesis and mechanisms of skin-lightening agents--existing and new approaches. Int. J. Cosmet. Sci. 33, 210-221. https://doi.org/10.1111/j.1468-2494.2010.00616.x
  8. Goldberg, D. M. (1996) More on antioxidant activity of resveratrol in red wine. Clin. Chem. 42, 113-114.
  9. Hosoi, J., Abe, E., Suda, T. and Kuroki, T. (1985) Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid. Cancer Res. 45, 1474-1478.
  10. Kobayashi, T., Urabe, K., Winder, A., Jimenez-Cervantes, C., Imokawa, G., Brewington, T., Solano, F., Garcia-Borron, J. C. and Hearing, V. J. (1994) Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis. EMBO J. 13, 5818-5825.
  11. Lin, C. B., Babiarz, L., Liebel, F., Roydon, P. E, Kizoulis, M., Gendimenico, G. J, Fisher, D. E. and Seiberg, M. (2002) Modulation of microphthalmia-associated transcription factor gene expression alters skin pigmentation. J. Invest. Dermatol. 119, 1330-1340. https://doi.org/10.1046/j.1523-1747.2002.19615.x
  12. Marchal, J., Pifferi, F. and Aujard, F. (2013) Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span. Ann. N. Y. Acad. Sci. 1290, 67-73. https://doi.org/10.1111/nyas.12214
  13. Moon, E. J, Kim, A. J. and Kim, S. Y. (2012) Sarsasapogen inincreases melanin synthesis via induction of tyrosinase and microphthalmia-associated transcription Factor Expression in melan-a cells. Biomol. Ther. 20, 340-345. https://doi.org/10.4062/biomolther.2012.20.3.340
  14. Newton, R. A., Cook, A. L., Roberts, D. W., Leonard, J. H., Sturm, R. A. (2007) Post-transcriptional regulation of melanin biosynthetic enzymes by cAMP and resveratrol in human melanocytes. J. Invest. Dermatol. 127, 2216-2227. https://doi.org/10.1038/sj.jid.5700840
  15. Ohguchi, K., Tanaka, T., Ito, T., Iinuma, M., Matsumoto, K., Akao, Y. and Nozawa, Y. (2003) Inhibitory effects of resveratrol derivatives from dipterocarpaceae plants on tyrosinase activity. Biosci. Biotechnol. Biochem. 67, 1587-1589. https://doi.org/10.1271/bbb.67.1587
  16. Osman, A. M., Al-Harthi, S. E., Alarabi, O. M., Elshal, M. F., Ramadan, W. S., Alaama, M. N., Al-Kreathy, H. M., Damanhouri, Z. A. and Osman, O. H. (2013) Chemosensetizing and cardioprotective effects of resveratrol in doxorubicin- treated animals. Cancer Cell Int. 13, 52. https://doi.org/10.1186/1475-2867-13-52
  17. Riley, P. A. (1997) Melanin. Int. J. Biochem. Cell Biol. 29, 1235-1239. https://doi.org/10.1016/S1357-2725(97)00013-7
  18. Shin, N. H., Ryu, S. Y., Choi, E. J., Kang, S. H., Chang, I. M., Min, K. R. and Kim, Y. (1998) Oxyresveratrol as the potent inhibitor on dopa oxidase activity of mushroom tyrosinase. Biochem. Biophys. Res. Commun. 243, 801-803. https://doi.org/10.1006/bbrc.1998.8169
  19. Song, S. H., Min, H. Y. and Lee, S. K. (2010) Suppression of prostaglandin E2-mediated cell proliferation and signal transduction by resveratrol in human colon cancer cells. Biomol. Ther. 18, 402-410. https://doi.org/10.4062/biomolther.2010.18.4.402
  20. Wu, Y., Jia, L. L., Zheng, Y. N., Xu, X. G., Luo, Y. J., Wang, B., Chen, J. Z., Gao, X. H., Chen, H. D., Matsui, M. and Li, Y. H. (2012) Resveratrate protects human skin from damage due to repetitive ultraviolet irradiation. J. Eur. Acad. Dermatol. Venereol. 27, 345-350
  21. Yanagihara, M., Yoshimatsu, M., Inoue, A., Kanno, T., Tatefuji, T. and Hashimoto, K. (2012) Inhibitory effect of gnetin C, a resveratrol dimer from melinjo (Gnetum gnemon), on tyrosinase activity and melanin biosynthesis. Biol. Pharm. Bull. 35, 993-996. https://doi.org/10.1248/bpb.35.993

피인용 문헌

  1. Hypopigmenting Effects of Extracts from Bulbs of Lilium Oriental Hybrid 'Siberia' in Murine B16/F10 Melanoma Cells vol.43, pp.5, 2014, https://doi.org/10.3746/jkfn.2014.43.5.705
  2. Resveratrol-Enriched Rice Down-Regulates Melanin Synthesis in UVB-Induced Guinea Pigs Epidermal Skin Tissue vol.22, pp.5, 2014, https://doi.org/10.4062/biomolther.2014.098
  3. Demethyleugenol β-Glucopyranoside Isolated from Agastache rugosa Decreases Melanin Synthesis via Down-regulation of MITF and SOX9 vol.64, pp.41, 2016, https://doi.org/10.1021/acs.jafc.6b03256
  4. Skin hyperpigmentation treatment using herbs: A review of clinical evidences 2017, https://doi.org/10.1080/14764172.2017.1368666
  5. A Study on Peanut Spouts Extract as the Anti-oxidant Activity and the Skin Whitening Cosmetic Ingredients vol.31, pp.1, 2016, https://doi.org/10.7841/ksbbj.2016.31.1.14
  6. Commercialized machine for soaking and slicing peanuts to induce resveratrol production 2018, https://doi.org/10.1111/jfpe.12611
  7. Anti-Melanogenic Potentials of Nanoparticles from Calli of Resveratrol-Enriched Rice against UVB-Induced Hyperpigmentation in Guinea Pig Skin vol.24, pp.1, 2016, https://doi.org/10.4062/biomolther.2015.165
  8. Transcriptional response networks for elucidating mechanisms of action of multitargeted agents vol.21, pp.7, 2016, https://doi.org/10.1016/j.drudis.2016.03.001
  9. Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors vol.32, pp.1, 2017, https://doi.org/10.1080/14756366.2016.1256882
  10. Use of Polyphenolic Compounds in Dermatologic Oncology vol.17, pp.4, 2016, https://doi.org/10.1007/s40257-016-0193-5
  11. Resveratrol as an anti-cancer agent: A review 2018, https://doi.org/10.1080/10408398.2016.1263597
  12. Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes vol.18, pp.2, 2017, https://doi.org/10.3390/ijms18020471
  13. Modulation of Melanin Synthesis by Amaranthus spp. L Seed Extract in Melan-a Cells vol.22, pp.3, 2016, https://doi.org/10.20307/nps.2016.22.3.168
  14. Mitochondrial dynamics regulate melanogenesis through proteasomal degradation of MITF via ROS-ERK activation vol.27, pp.6, 2014, https://doi.org/10.1111/pcmr.12298
  15. The pharmacology of resveratrol in animals and humans vol.1852, pp.6, 2015, https://doi.org/10.1016/j.bbadis.2015.01.014
  16. Biological Activities of Stilbenoids vol.19, pp.3, 2018, https://doi.org/10.3390/ijms19030792
  17. Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells vol.41, pp.3, 2018, https://doi.org/10.1007/s12272-018-1002-x
  18. New automated peanut kernel slicing machine for enhanced stilbenoid production vol.41, pp.7, 2018, https://doi.org/10.1080/02533839.2018.1531061
  19. Resveratrol as an active ingredient for cosmetic and dermatological applications: a review pp.1476-4180, 2018, https://doi.org/10.1080/14764172.2018.1469767
  20. Resveratrol as a Multifunctional Topical Hypopigmenting Agent vol.20, pp.4, 2019, https://doi.org/10.3390/ijms20040956
  21. Inhibitors of Melanogenesis: An Updated Review vol.61, pp.17, 2014, https://doi.org/10.1021/acs.jmedchem.7b00967
  22. Osmanthus fragrans Flower Aqueous Extract and its Enriched Acteoside inhibit Melanogenesis and Ultraviolet-induced Pigmentation vol.13, pp.5, 2018, https://doi.org/10.1177/1934578x1801300515
  23. 바나나 껍질 에탄올 추출물이 멜라닌 합성에 미치는 영향 vol.28, pp.7, 2018, https://doi.org/10.5352/jls.2018.28.7.802
  24. Advances in the Tyrosinase Inhibitors from Plant Source vol.26, pp.18, 2014, https://doi.org/10.2174/0929867325666180522091311
  25. Resveratrol: Twenty Years of Growth, Development and Controversy vol.27, pp.1, 2014, https://doi.org/10.4062/biomolther.2018.176
  26. Isolation and enhancement of resveratrol production in Xylaria psidii by exploring the phenomenon of epigenetics: using DNA methyltransferases and histone deacetylase as epigenetic modifiers vol.46, pp.4, 2014, https://doi.org/10.1007/s11033-019-04862-z
  27. Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications vol.8, pp.9, 2014, https://doi.org/10.3390/antiox8090332
  28. 품종별 땅콩 종피 추출물의 효소저해활성 및 암세포주 증식억제 효과 vol.32, pp.5, 2014, https://doi.org/10.9799/ksfan.2019.32.5.511
  29. Tyrosinase‐catalyzed oxidation of resveratrol produces a highly reactive ortho‐quinone: Implications for melanocyte toxicity vol.32, pp.6, 2014, https://doi.org/10.1111/pcmr.12808
  30. Natural skin-whitening compounds for the treatment of melanogenesis (Review) vol.20, pp.1, 2014, https://doi.org/10.3892/etm.2020.8687
  31. Characteristics, Biological Properties and Analytical Methods of Trans-Resveratrol: A Review vol.50, pp.4, 2014, https://doi.org/10.1080/10408347.2019.1637242
  32. Oxyresveratrol-induced Activation of Nrf2/HO-1 Signaling Pathway Enhances Ability of Resveratrol to Inhibit UVB-induced Melanin vol.4, pp.3, 2014, https://doi.org/10.1097/jd9.0000000000000135
  33. Antimelanogenesis Effects of Leaf Extract and Phytochemicals from Ceylon Olive (Elaeocarpus serratus) in Zebrafish Model vol.13, pp.7, 2014, https://doi.org/10.3390/pharmaceutics13071059
  34. Oxidative stress in the skin: Impact and related protection vol.43, pp.5, 2014, https://doi.org/10.1111/ics.12728
  35. Pterostilbene Inhibits the Melanogenesis Activity in UVB-Irradiated B164A5 Cells vol.19, pp.4, 2014, https://doi.org/10.1177/15593258211047651
  36. Grape Extract Promoted α-MSH-Induced Melanogenesis in B16F10 Melanoma Cells, Which Was Inverse to Resveratrol vol.26, pp.19, 2014, https://doi.org/10.3390/molecules26195959