DOI QR코드

DOI QR Code

The Effects of Bronchoscope Diameter on the Diagnostic Yield of Transbronchial Lung Biopsy of Peripheral Pulmonary Nodules

  • Lee, Nakwon (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Kim, Sang-Ha (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Kwon, Woocheol (Department of Radiology, Yonsei University Wonju College of Medicine) ;
  • Lee, Myoung Kyu (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Yong, Suk Joong (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Shin, Kye Chul (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Jung, Ye-Ryung (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Choi, Yeun Seoung (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Choi, Jiwon (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Choi, Ji Sun (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Lee, Won Yeon (Department of Internal Medicine, Yonsei University Wonju College of Medicine)
  • 투고 : 2014.05.16
  • 심사 : 2014.10.29
  • 발행 : 2014.12.31

초록

Background: Transbronchial lung biopsy (TBLB) is a valuable diagnostic tool for peripheral pulmonary lesions. The diagnostic yield of TBLB reportedly ranges from 41%-60%. Many studies demonstrated the various factors that influence the yield of TBLB, including size, location, and distance from the carina or pleura. However, no study has evaluated the effects of the bronchoscope diameter. We evaluated whether the bronchoscope diameter affected the diagnostic yield of TBLB. Methods: We reviewed records from 178 patients who underwent TBLB using bronchoscopes of two different diameters (5.7 mm, thick outer diameter, Olympus BF-200; 4.9 mm, thin, BF-260). The fluoroscopic guidance rates, yield of TBLB and flexible bronchoscopy (FB) were compared between the two groups. Additionally, we compared the results of the procedures with respect to diagnosis, distance from the pleura, and size of the lesion. Results: The results of fluoroscopic guidance, TBLB, and FB yield using thin diameter bronchoscope were significantly better than those obtained with a thick diameter bronchoscope (p=0.021, p=0.036, and p=0.010, respectively). Particularly, when the distance from the pleura was ${\leq}10mm$, success rates for fluoroscopic guidance and FB with thin bronchoscope were higher (p=0.013 and p=0.033, respectively), as compared to with thick bronchoscope. Conclusion: A thinner diameter bronchoscope increased the yield of bronchoscopy, and bronchial washing in conjunction with TBLB was useful in the diagnosis of peripheral pulmonary nodules.

키워드

참고문헌

  1. Levin DC, Wicks AB, Ellis JH Jr. Transbronchial lung biopsy via the fiberoptic bronchoscope. Am Rev Respir Dis 1974;110: 4-12.
  2. Andersen HA. Transbronchial lung biopsy in diffuse pulmonary disease. Ann Thorac Surg 1977;24:1. https://doi.org/10.1016/S0003-4975(10)64559-6
  3. Ellis JH Jr. Transbronchial lung biopsy via the fiberoptic bronchoscope: experience with 107 consecutive cases and comparison with bronchial brushing. Chest 1975;68:524-32. https://doi.org/10.1378/chest.68.4.524
  4. Zavala DC. Diagnostic fiberoptic bronchoscopy: techniques and results of biopsy in 600 patients. Chest 1975;68:12-9. https://doi.org/10.1378/chest.68.1.12
  5. Chechani V. Bronchoscopic diagnosis of solitary pulmonary nodules and lung masses in the absence of endobronchial abnormality. Chest 1996;109:620-5. https://doi.org/10.1378/chest.109.3.620
  6. Baaklini WA, Reinoso MA, Gorin AB, Sharafkaneh A, Manian P. Diagnostic yield of fiberoptic bronchoscopy in evaluating solitary pulmonary nodules. Chest 2000;117:1049-54. https://doi.org/10.1378/chest.117.4.1049
  7. Radke JR, Conway WA, Eyler WR, Kvale PA. Diagnostic accuracy in peripheral lung lesions. Factors predicting success with flexible fiberoptic bronchoscopy. Chest 1979;76:176-9. https://doi.org/10.1378/chest.76.2.176
  8. Fletcher EC, Levin DC. Flexible fiberoptic bronchoscopy and fluoroscopically guided transbronchial biopsy in the management of solitary pulmonary nodules. West J Med 1982;136: 477-83.
  9. Wallace JM, Deutsch AL. Flexible fiberoptic bronchoscopy and percutaneous needle lung aspiration for evaluating the solitary pulmonary nodule. Chest 1982;81:665-71. https://doi.org/10.1378/chest.81.6.665
  10. de Gracia J, Bravo C, Miravitlles M, Tallada N, Orriols R, Bellmunt J, et al. Diagnostic value of bronchoalveolar lavage in peripheral lung cancer. Am Rev Respir Dis 1993;147:649-52. https://doi.org/10.1164/ajrccm/147.3.649
  11. Shiner RJ, Rosenman J, Katz I, Reichart N, Hershko E, Yellin A. Bronchoscopic evaluation of peripheral lung tumours. Thorax 1988;43:887-9. https://doi.org/10.1136/thx.43.11.887
  12. Stringfield JT, Markowitz DJ, Bentz RR, Welch MH, Weg JG. The effect of tumor size and location on diagnosis by fiberoptic bronchoscopy. Chest 1977;72:474-6. https://doi.org/10.1378/chest.72.4.474
  13. Torrington KG, Kern JD. The utility of fiberoptic bronchoscopy in the evaluation of the solitary pulmonary nodule. Chest 1993;104:1021-4. https://doi.org/10.1378/chest.104.4.1021
  14. Cortese DA, McDougall JC. Biopsy and brushing of peripheral lung cancer with fluoroscopic guidance. Chest 1979;75:141-5. https://doi.org/10.1378/chest.75.2.141
  15. Lai RS, Lee SS, Ting YM, Wang HC, Lin CC, Lu JY. Diagnostic value of transbronchial lung biopsy under fluoroscopic guidance in solitary pulmonary nodule in an endemic area of tuberculosis. Respir Med 1996;90:139-43. https://doi.org/10.1016/S0954-6111(96)90155-9
  16. Rooney CP, Wolf K, McLennan G. Ultrathin bronchoscopy as an adjunct to standard bronchoscopy in the diagnosis of peripheral lung lesions: a preliminary report. Respiration 2002; 69:63-8. https://doi.org/10.1159/000049372
  17. Bose S, Ghatol A, Eberlein M, Yung RC. Ultrathin bronchoscopy in the diagnosis of peripheral cavitary lung lesions. J Bronchology Interv Pulmonol 2013;20:167-70. https://doi.org/10.1097/LBR.0b013e3182904987

피인용 문헌

  1. Utility of Radial Probe Endobronchial Ultrasound-Guided Transbronchial Lung Biopsy in Diffuse Lung Lesions vol.82, pp.3, 2014, https://doi.org/10.4046/trd.2018.0073
  2. A variety of bacterial aetiologies in the lower respiratory tract at patients with endobronchial tuberculosis vol.15, pp.6, 2020, https://doi.org/10.1371/journal.pone.0234558
  3. Technologies for targeting the peripheral pulmonary nodule including robotics vol.25, pp.9, 2014, https://doi.org/10.1111/resp.13791