Tuberculosis and Respiratory Diseases

  • 제77권6호
  • /
  • Pages.237-242
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  • 2014
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  • 1738-3536(pISSN)
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  • 2005-6184(eISSN)
대한결핵및호흡기학회 (The Korean Academy of Tuberculosis and Respiratory Diseases)
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Respiratory Review of 2014: Asthma

  • Yoon, Ho Il (Department of Internal Medicine, Seoul National University College of Medicine)
  • 투고 : 2014.11.17
  • 심사 : 2014.12.01
  • 발행 : 2014.12.31
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⟨ 이전 논문 다음 논문 ⟩

초록

Asthma is a chronic inflammatory disease of the airway that comprises a variety of etiologies and inflammatory phenotypes. Clinically, there is a wide range of patients with varying severities and responses to individual drugs. The introduction of inhaled corticosteroid therapy has dramatically changed the treatment of asthma. Recent development of new therapies suggests the possibility of another breakthrough. These can be categorized as follows: anti-cytokine therapies that usually target eosinophilic inflammation, sublingual immunotherapy, and bronchial thermoplasty. In this paper, we will review the major articles related to asthma treatment that were published in 2013.

키워드

참고문헌

  1. Wenzel S, Ford L, Pearlman D, Spector S, Sher L, Skobieranda F, et al. Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med 2013;368:2455-66. https://doi.org/10.1056/NEJMoa1304048
  2. Busse WW, Holgate S, Kerwin E, Chon Y, Feng J, Lin J, et al. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am J Respir Crit Care Med 2013;188:1294-302. https://doi.org/10.1164/rccm.201212-2318OC
  3. Laviolette M, Gossage DL, Gauvreau G, Leigh R, Olivenstein R, Katial R, et al. Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia. J Allergy Clin Immunol 2013;132:1086-96. https://doi.org/10.1016/j.jaci.2013.05.020
  4. Lin SY, Erekosima N, Kim JM, Ramanathan M, Suarez-Cuervo C, Chelladurai Y, et al. Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review. JAMA 2013;309:1278-88. https://doi.org/10.1001/jama.2013.2049
  5. Sadatsafavi M, Lynd L, Marra C, Bedouch P, Fitzgerald M. Comparative outcomes of leukotriene receptor antagonists and long-acting beta-agonists as add-on therapy in asthmatic patients: a population-based study. J Allergy Clin Immunol 2013;132:63-9. https://doi.org/10.1016/j.jaci.2013.02.007
  6. Wechsler ME, Laviolette M, Rubin AS, Fiterman J, Lapa e Silva JR, Shah PL, et al. Bronchial thermoplasty: long-term safety and effectiveness in patients with severe persistent asthma. J Allergy Clin Immunol 2013;132:1295-302. https://doi.org/10.1016/j.jaci.2013.08.009
  7. McKeever T, Harrison TW, Hubbard R, Shaw D. Inhaled corticosteroids and the risk of pneumonia in people with asthma: a case-control study. Chest 2013;144:1788-94. https://doi.org/10.1378/chest.13-0871
  8. Tse SM, Li L, Butler MG, Fung V, Kharbanda EO, Larkin EK, et al. Statin exposure is associated with decreased asthmarelated emergency department visits and oral corticosteroid use. Am J Respir Crit Care Med 2013;188:1076-82. https://doi.org/10.1164/rccm.201306-1017OC
  9. Short PM, Williamson PA, Anderson WJ, Lipworth BJ. Randomized placebo-controlled trial to evaluate chronic dosing effects of propranolol in asthma. Am J Respir Crit Care Med 2013;187:1308-14. https://doi.org/10.1164/rccm.201212-2206OC

피인용 문헌

  1. Metabolic Functions of the Lung, Disorders and Associated Pathologies vol.8, pp.10, 2016, https://doi.org/10.14740/jocmr2668w
  2. Investigation of the Possible Role of the Hippo/YAP1 Pathway in Asthma and Allergy vol.9, pp.3, 2014, https://doi.org/10.4168/aair.2017.9.3.247
  3. Asthma-COPD Overlap Shows Favorable Clinical Outcomes Compared to Pure COPD in a Korean COPD Cohort vol.9, pp.5, 2017, https://doi.org/10.4168/aair.2017.9.5.431