Genomics & Informatics

Korea Genome Organization (한국유전체학회)
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Replication of Interactions between Genome-Wide Genetic Variants and Body Mass Index in Fasting Glucose and Insulin Levels

  • Hong, Kyung-Won (Division of Biomedical Informatics, Center for Genome Science, National Institute of Health, KCDC) ;
  • Chung, Myungguen (Division of Biomedical Informatics, Center for Genome Science, National Institute of Health, KCDC) ;
  • Cho, Seong Beom (Division of Biomedical Informatics, Center for Genome Science, National Institute of Health, KCDC)
  • Received : 2014.11.01
  • Accepted : 2014.11.24
  • Published : 2014.12.31
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Abstract

The genetic regulation of glucose and insulin levels might be modified by adiposity. With regard to the genetic factors that are altered by adiposity, a large meta-analysis on the interactions between genetic variants and body mass index with regard to fasting glucose and insulin levels was reported by the Meta-Analyses of Glucose- and Insulin-related trait Consortium (MAGIC), based on European ancestry. Because no replication study has been performed in other ethnic groups, we first examined the link between reported single-nucleotide polymorphisms (SNPs) and fasting glucose and insulin levels in a large Korean cohort (Korean Genome and Epidemiology Study cohort [KoGES], n = 5,814). The MAGIC study reported 7 novel SNPs for fasting glucose levels and 6 novel SNPs for fasting insulin levels. In this study, we attempted to replicate the association of 5 SNPs with fasting glucose levels and 5 SNPs with fasting insulin levels. One SNP (rs2293941) in PDX1 was identified as a significant obesity-modifiable factor in Koreans. Our results indicate that the novel loci that were identified by MAGIC are poorly replicated in other ethnic groups, although we do not know why.

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References

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